Chemical Xenogenization of Experimental Tumors by Antineoplastic Drugs
The antigenic phenotype of experimental tumors can be modified through procedures that either directly -and rather transiently, as a rule- affect the membrane structures of the cell or involve stable, often hereditary, changes in the cell biology (e.g., the genetic code). The term of chemical xenogenizationwas introduced by our group to indicate the appearance of tumor-associated transplantation antigens in murine tumors subjected to chemical treatment, and thus rendered antigenically foreign to the host of origin (Puccetti et al., 1987). Bonmassar et al. (1970) had indeed found that murine leukemia cells, on repeated in vivo exposure to the antitumor agent dacarbazine, would become increasingly immunogenic, eventually acquiring a degree of foreignness capable of resulting in tumor cell rejection by the histocompatible host.
KeywordsParental Cell Cancer Immunol Parental Tumor Tumor Variant Murine Lymphoma
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