Abstract
In 1941 Huggins and Hodges [22] demonstrated the effect of androgen deprivation on prostatic carcinoma in experimental studies and by clinical observation. Since then, androgen deprivation has become the standard treatment of metastatic prostate cancer. About 25% of patients do not respond to this treatment initially and another 50% show a progression of the disease in the follow-up [47]. That means that more than 75% of patients need an additional treatment.
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Rübben, H., Rembrink, K., Johnston, T. (1993). Chemotherapy of Prostatic Carcinoma. In: Ackermann, R., Diehl, V. (eds) Malignancies of the Genitourinary Tract. Recent Results in Cancer Research, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84583-3_7
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DOI: https://doi.org/10.1007/978-3-642-84583-3_7
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