Neoadjuvant Versus Adjuvant Chemotherapy in Invasive Bladder Cancer

  • H. I. Scher
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 126)


Invasive bladder tumors represents a range of diseases that vary clinically from minimally invasive with a low metastatic potential, to high grade lesions that metastasize early despite minimal invasion, to large fixed lesions that present with urinary obstruction and pain [1,2]. As the prognosis for each of these groups varies, so should the therapy. Too often, however, a uniform treatment approach is used for all of these clinical scenarios. This approach is becoming outmoded; while the treatment options for invasive bladder tumors are myriad, it is now apparent that chemotherapy is playing an increasingly important role in the management of these malignancies [3]. This is based on the high rate of systemic failure—the major cause of mortality following local treatment modalities—the high response proportion to modern combination regimens, and the possibility that chemotherapy may allow organ preservation. Critical to improving treatment selection for an individual patient is the refinement of our ability to define the biologic behavior of these tumors, both with respect to metastatic risk and sensitivity to treatment. Only then can a specific approach be advised that offers the highest probability of cure with the least morbidity.


Bladder Cancer Radical Cystectomy Invasive Bladder Cancer Response Proportion Partial Cystectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. I. Scher
    • 1
  1. 1.Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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