Screening for Carcinoma of the Prostate: Epidemiological and Methodological Aspects

  • P. Iversen
  • S. T. Torp-Pedersen
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 126)


Cancer of the prostate constitutes a significant health problem. In Denmark prostatic cancer is the third leading cause of death from cancer in men, following lung and colorectal cancer [14,28]. The incidence and mortality have increased significantly over the last four decades [7]. In part, this trend may be explained by better diagnostic capabilities and improved registration, but data from other Nordic countries and international reports [41] support a true increase in incidence of the disease.


Prostatic Cancer Lead Time Radical Prostatectomy Digital Rectal Examination Prostatic Acid Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ackermann R, Frohmüller HGW (1983) Complications and morbidity following radical prostatectomy. World J Urol 1:62–67CrossRefGoogle Scholar
  2. 2.
    Adami H-O (1988) Strategies for control of prostatic cancer mortality with some methodologic comments. Scand J Urol Nephrol Suppl 110:15–22PubMedGoogle Scholar
  3. 3.
    Adami H-O, Norlén BJ, Malker B, Meirik O (1986) Long-term survival in prostatic carcinoma, with special reference to age as a prognostic factor. A nation-wide study. Scand J Urol Nephrol 20:107–112PubMedCrossRefGoogle Scholar
  4. 4.
    Annual Cancer Statistics Review including Cancer Trends: 1950-1985 (1988). National Cancer Institute, BethesdaGoogle Scholar
  5. 5.
    Bagshaw MA, Ray GR, Cox RS (1987) Selecting initial therapy for prostate cancer. Radiation therapy perspective. Cancer 60:521–525PubMedCrossRefGoogle Scholar
  6. 6.
    Breslow N, Chan CW, Dhom G, Drury RAB, Franks LM, Gellei B, Lee YS, Lundberg S, Sparke B, Sternby NH, Tulinius H (1977) Latent carcinoma of prostate at autopsy in seven areas. Int J Cancer 20:680–688PubMedCrossRefGoogle Scholar
  7. 7.
    Carstensen B, Storm HH (1987) Overlevelseskurver fra Cancerregisteret 1948-82. Danish Cancer RegistryGoogle Scholar
  8. 8.
    Chodak GW (1988) Early detection of prostate cancer. Presented at the International Symposium on Endocrine Therapy, MonacoGoogle Scholar
  9. 9.
    Chodak GW, Keller P, Schoenberg H (1989) Assessment of screening for prostate cancer using the digital rectal examination. J Urol 141:1136–1138PubMedGoogle Scholar
  10. 10.
    Chodak GW, Keller P, Schoenberg H (1988) Routine screening for prostate cancer using the digital rectal examination. In: Schroeder FH et al. (eds) EORTC Genitourinary Group, monograph 5: progress and controversies in oncological urology II. Liss, New York, pp 87–95Google Scholar
  11. 11.
    Cochrane AL, Holland WW (1971) Validation of screening procedures. Br Med Bull 27:3–8PubMedGoogle Scholar
  12. 12.
    Cole P, Morrison AS (1978) Basic issues in cancer screening. In: Miller EB (ed) Screening in cancer. International Union Against Cancer, GenevaGoogle Scholar
  13. 13.
    Commission on Chronic Illness in the United States. Harvard University Press, CambridgeGoogle Scholar
  14. 14.
    Danish Cancer Society (1985) Danish Cancer Registry: cancer incidence in Denmark 1985Google Scholar
  15. 15.
    Franks LM (1954) Latent carcinoma of the prostate. J Pathol Bacteriol 68:603–616PubMedCrossRefGoogle Scholar
  16. 16.
    Gilbertsen VA (1971) Cancer of the prostate gland. Results of early diagnosis and therapy undertaken for cure of the disease. JAMA 215:81–84PubMedCrossRefGoogle Scholar
  17. 17.
    Henderson M (1976) Validity of screening. Cancer 37:573–581PubMedCrossRefGoogle Scholar
  18. 18.
    Jacobi GH (1987) Early detection of prostatic carcinoma: the German experience. Presented at: Progress and Controversies in Oncological Urology II, AmsterdamGoogle Scholar
  19. 19.
    Johansson J-E, Adami H-O, Andersson S-O, Bergström R, Krusemo UB, Kraaz W (1989) Natural history of localised prostatic cancer: A population-based study in 223 untreated patients. Lancet i:799–803CrossRefGoogle Scholar
  20. 20.
    Lee F, Littrup PJ, Torp-Pedersen ST, Mettlin C, McHugh TA, Gray JM, Kumasaka GH, McLeary RD (1988) Prostate cancer: comparison of transrectal US and digital rectal examination for screening. Radiology 168:389–394PubMedGoogle Scholar
  21. 21.
    Life table for the years 1985-1986. (1988) Statistical Year BookGoogle Scholar
  22. 22.
    Love RR (1985) Principles of cancer screening. In: Stoll BA (ed) New horizons in oncology: screening and monitoring of cancer, vol 4. Wiley, New YorkGoogle Scholar
  23. 23.
    Love RR, Camilli AE (1981) The value of screening. Cancer 48:489–494PubMedCrossRefGoogle Scholar
  24. 24.
    McClennan BL (1988) Transrectal US of the prostate: is the technology leading the science? Radiology 168:571–575PubMedGoogle Scholar
  25. 25.
    McNeal JE, Bostwick DG, Kindrachuk RA, Redwine EA, Freiha FS, Stamey TA (1986) Patterns of progression in prostate cancer. Lancet i:60–63CrossRefGoogle Scholar
  26. 26.
    Mueller EJ, Crain TW, Thompson IM, Rodriguez FR (1988) An evaluation of serial digital rectal examination in screening for prostate cancer. J Urol 140:1445–1447PubMedGoogle Scholar
  27. 27.
    Murphy GP, Natarajan N, Pontes JE, Schmitz RL, Smart CR, Schmidt JD, Mettlin C (1982) The national survey of prostate cancer in the United States by the American College of Surgeons. J Urol 127:928–934PubMedGoogle Scholar
  28. 28.
    National Board of Health (1985) Causes of death in DenmarkGoogle Scholar
  29. 29.
    Ragde H, Aldape HC, Blasko JC, Bagley CM (1988) Prostate cancer screening with high resolution transrectal ultrasound. Presented at the 3rd International Symposium on Transrectal Ultrasound of the Prostate, KielGoogle Scholar
  30. 30.
    Resnick M (1988) Background for screening — epidemiology and cost effectiveness. In: Schroeder FH et al. (eds) EORTC Genitourinary Group monograph 5: progress and controversies in oncological urology II. Liss, New York, pp 111–120Google Scholar
  31. 31.
    Sheldon CA, Williams RD, Fraley EE (1980) Incidental carcinoma of the prostate: a review of the literature and critical reappraisal of classification. J Urol 124:626–631PubMedGoogle Scholar
  32. 32.
    Sogani PC, Fair WR (1987) Treatment of advanced prostatic cancer. Urol Clin North Am 14:353–371PubMedGoogle Scholar
  33. 33.
    Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317:909–916PubMedCrossRefGoogle Scholar
  34. 34.
    Starklint H (1950) Unders0gelser over latent og manifest prostatacancer. Munksgård, CopenhagenGoogle Scholar
  35. 35.
    Tannock IF (1985) Is there evidence that chemotherapy is of benefit to patients with carcinoma of the prostate? J Clin Oncol 3:1013–1021PubMedGoogle Scholar
  36. 36.
    Thompson IM, Ernst JJ, Gangai MP, Spence CR (1984) Adenocarcinoma of the prostate: results of routine urological screening. J Urol 132:690–692PubMedGoogle Scholar
  37. 37.
    Thompson IM, Rounder JB, Teague JL, Peek M, Spence CR (1987) Impact of routine screening for adenocarcinoma of the prostate on stage distribution. J Urol 137:424–426PubMedGoogle Scholar
  38. 38.
    Varenhorst E, Enlund A-L, Herder A, Malmquist E, Berglund K, Löfman O, Carlsson P, Pedersen K (1989) Prostatacancerscreening med rektalpalpation kan organiseres til rimlig kostnad. Läkartidningen 86:3475–3477PubMedGoogle Scholar
  39. 39.
    Veterans Administration Cooperative Urological Research Group (1967) Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 124:1011–1017Google Scholar
  40. 40.
    Walsh PC, Lepor H (1987) The role of radical prostatectomy in the management of prostatic cancer. Cancer 60:526–537PubMedCrossRefGoogle Scholar
  41. 41.
    Waterhouse J, Muir C, Shanmugaratnam K, Powell J (1982) Cancer incidence in five continents, vol 4. IARC, Lyon (IARC scientific publication no 42)Google Scholar
  42. 42.
    Watson RA, Tang DB (1980) The predictive value of prostatic acid phosphatase as a screening test for prostate cancer. N Engl J Med 303:497–499PubMedCrossRefGoogle Scholar
  43. 43.
    Zaridze DG, Boyle P (1987) Cancer of the prostate: epidemiology and aetiology. Br J Urol 59:493–502PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Iversen
    • 1
  • S. T. Torp-Pedersen
    • 1
  1. 1.Department of UrologyHerlev HospitalHerlevDenmark

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