Pharmacotherapy of the Respiratory Muscle
The respiratory system consists of a gas-exchanging organ, the lungs and a pump that ventilates them. The pump consists of the chest wall, which includes the rib cage, the respiratory muscles, and the respiratory centers in the central nervous system which control the diaphragm and the muscles used to expand the chest wall during breathing. The pump is the working or active part of the respiratory system, the lungs being merely passively inflated when the respiratory muscles contracts. The pump is just as vital as the heart, since without it, the lungs would obviously be unable to function, and arterial blood gas homeostasis would not be maintained.
KeywordsChronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Respiratory Muscle Respiratory Muscle Function Transdiaphragmatic Pressure
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- 4.Aubier M, Viires N, Piquet J, et al (1985) Effects of hypocalcemia on diaphragmatic strength generation. J Appl Physiol 58:2053–2061Google Scholar
- 5.Viires N, Murciano D, Seta JP, Dureuil B, Pariente R, Aubier M (1988) Effects of Ca2+ withdrawal on diaphragmatic fiber tension generation. J Appl Physiol 64:15–19Google Scholar
- 9.Adachi H, Strauss W, Ochi H, Wagner HN Jr (1976) The effects of hypoxia on the regional distribution of cardiac output in the dog. Cir Res 39:314–319Google Scholar
- 11.Moran N (1972) The effects of cardiac glycosides on mechanical properties of heart muscle. In: Marks BM, Weisler AM (eds) Basic and Clinical Pharmacology of Digitalis. Springfield, Illinois, Thomas, pp. 94–117Google Scholar
- 18.Aubier M, Murciano D, Viires N, Lecoguic Y, Pariente R (1985) Diaphragmatic contractility enhanced by aminophylline: role of extracellular calcium. J App Physiol 54:460–464Google Scholar
- 19.Potreau D, Raymond G (1979) Calcium-dependent electrical activity and contraction of voltage clamped frog single muscle fibers. J Physiol (London) 307:9–22Google Scholar
- 20.Prosdocini M, Bianchi CP (1981) Effect of adenosine on oxygen uptake and electrolyte content of frog muscle. J Pharmacol Exp Ther 218:87–96Google Scholar
- 21.Sawynok J, Thamandas KH (1976) Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: Antagonism by theophylline. J Pharmacol Exp Ther 197:379–390Google Scholar
- 27.Nietrzeba RM, Elliott GG, Adams TD, Yeh MP, Yanowitz FG (1984) Effects of aminophylline upon the exercise performance of patients with stable respiration. Eur J Resp Dis 20:361–367Google Scholar
- 28.Malher DA, Matthay RA, Snyder PE, Wells CK, Loke J (1985) Sustained-release theophylline reduces dyspnea in non-reversible obstructive airway disease. Am Rev Respir Dis 131:22–25Google Scholar
- 31.Aubier M, Murciano D, Menu Y, Boczkowski J, Mai H, Pariente R (1989) Dopamine effects on diaphragmatic strength during acute respiratory failure in chronic obstructive pulmonary disease. Ann Intern Med 110:107–123Google Scholar
- 33.Schader JH, Juan G, Hawell S, Fitzgerald R, Roussos C (1985) Arterial C02 partial pressure effects diaphragmatic function. J Appl Physiol 58:823–829Google Scholar