Zusammenfassung
Zwangsphänomene sind wie Ängste und depressive Verstimmungen ubiquitäre Erscheinungen. Das gleiche gilt für andere, in ihrer Erscheinungsform teils unterschiedlich ausgestaltete impulshafte Handlungsweisen. Das pathologisch gesteigerte und schließlich mit subjektiver Beeinträchtigung und daraus resultierender sozialer Dysfunktion einhergehende Auftreten von Zwängen wird klinisch meist als Zwangsneurose bezeichnet. In den letzten Jahrzehnten sind zunächst Beiträge zur Zwangsneurose vorwiegend im epidemiologischen und therapeutischen Bereich—hier vornehmlich von Verhaltenstherapeuten — erfolgt. Zur Ätiopathogenese und hier insbesondere zu den biologischen Grundlagen dieser Störung gibt es erst in den letzten Jahren neue Arbeiten (Insel 1988; Rapoport u. Wise 1988, Stahl 1988, McDougle u. Goodman 1990).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Asberg M; Nordström P (1988) Biological correlates of suicidal behavior. In: Müller HJ, Schmidtke A, Welz R (eds) Current issues of suicidology. Springer, Berlin Heidelberg New York Tokyo, pp 223–241
Asberg M, Träskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid. Arch Gen Psychiatry 33:1193–1197
Baxter LR, Thompson JM, Schwartz JM et al. (1987) Trazodone treatment response in obsessive-compulsive disorder-correlated with shifts in glucose metabolism in the caudate nuclei. Psychopathology 20 (suppl 1): 114–122
Benkelfat C, Murphy DL, Zohar J, Hill JL, Grover G, Insel TR (1989) Clomipramine in obsessive-compulsive disorder. Arch Gen Psychiatry 46:23–28
Brown CS, Kent TA, Bryant SG et al. (1989) Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res 27:5–12
Brown GL, Goodwin FK, Bellenger JD, Goyer PF, Major LF (1979) Aggression in humans correlates with cerebrospinal fluid metabolites. Psychiatry Res 1:131–139
Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK (1982) Aggression, suicide and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 139:741–746
Charney DS, Goodman WK, Price LH, Woods SW, Rasmussen SA, Heninger GR (1988) Serotonin function in obsessive-compulsive diesorder: a comparison of the effects to trytophan an m-chlorophenylpiperazine in patients and healthy subjects. Arch Gen Psychiatry 45:177–185
Esquirol E (1838) Des maladies mentales considerees sous le rapport medical, hygienique et medicolegal. Balliere, Paris
Flament MF, Rapoport JL, Berg CJ, Sceery W, Kilts C, Linnoila M (1985) Clomipramine treatment of childhood obsessive compulsive disorder: a double-blind controlles study. Arch Gen Psychiatry 42:977–983
Flament MF, Rapoport JL, Murphy DL, Big CT, Lake CR (1987) Biochemical changes during clomipramine treatment of childhood obsessive-compulsive disorder. Arch Gen Psychiatry 44:219–225
Foa EF, Steketee G, Kozak MJ, Dugger D (1987) Imipramine and placebo in the treatment of obsessive-compulsives: Their effect on depression and obsessional symptoms. Psychopharmacol Bull 23:8–11
Goodman WK, Price LH, Rasmussen SA, Delgado PL, Heninger GR, Charney DS (1989) Efficacy of fluovoxamine in obsessive-compulsive disorder: a double-blind comparison with placebo. Arch Gen Psychiatry 46:36–44
Grimshaw L (1964) Obsessional disorder and neurological illness. J Neurol Neurosurg Psychiatry 27:229
Hollander E, Fay M, Cohen B, Campeas J, Gorman JM, Liebowitz MR (1988) Serotonergic and noradrenergic sensitivity in obsessive compulsive disorder: behavioral findings. Am J Psychiatry 145:1015–1017
Hollander E, Schiffman E, Cohen B et al. (1990) Signs of central nervous system dysfunction in obsessive-compulsive disorder. Arch Gen Psychiatry 47:27–32
Insel TR (1988) Obsessive-compulsive disorder: a neuroethological perspective. Psychopharmacol Bull 24:365–369
Janet P (1903) Les obsessions et la psychasthenie. Alcan, Paris
Jaspers K (1909) Heimweh und Verbrechen. F.C.M. Vogel, Leipzig
Jenike M, Baer M, Minichiello W (1990) Obsessive-compulsive disorders: theory and management. Year Book Med. Publ., Chicago
Johnson FN (1984) The psychopharmacology of lithium. MacMillan, London
Karno M, Golding I, Sorensen S, Burnham M (1988) The epidemiology of obsessive-compulsive disorder in five U.S. communities. Arch Gen Psychiatry 45:1094–1099
Lesch KP, Hoh A, Müller T, Schulte HM, Osterheider M (1990a) 5-HT1A receptor responsitivity in obsessive-compulsive disorder. In: Proceedings 17th CINP, Vol 1. Kyoto, Japan, p 118
Lesch KP, Mayer S, Hoh A et al. (1990b) 5-Hydroxytryptamine-1A (5-HT1a) receptor function in affective disorders. Pharmacopsychiatry 22:205
Levine LR, Enas GG, Thompson WL (1989) Use of fluoxetine, a selective serotonin-uptake inhibitor, in the treatment of obesity: a dose-response study. Int J Obesity 13:635–645
Lidberg L, Asberg M, Scalia-Tomba GP, Bertilsson L (1985) Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand 71:230–236
Lombroso C (1891) L’Uomo delinquente. Turin
Lopez-Ibor JJ jr (1990) Impulsive control in obsessive-compulsive disorder: a biopsychopathological approach. Prog. Neuropsychopharmacol Biol Psychiatry 14:709–718
Luxenberg JS, Swedo SE, Flament MF, Friedland RP, Rapoport JL, Rapoport SI (1988) Neuroanatomic abnormities in obsessive-compulsive disorder detected with quantitative x-ray computed tomography. Am J Psychiatry 145:1089–1094
Markovitz PJ, Stagno SJ, Calabrese JR (1990) Buspirone augmentation of fluoxetine in obsessive-compulsive disorder. Am J Psychiatry 147:798–800
Marks IM, Stern RS, Mawson D, Cobb J, McDonald R (1980) Clomipramine and exposure for obsessive compulsive rituals, I. Br J Psych 136:1–25
Mavissakalian M, Turner SM, Michalson L, Jacob R (1985) Tricyclic antidepressants in obsessive-compulsive disorder: Antiobsessional or antidepressant agents? II. Am J Psychiatry 142:572–576
McDougle CJ, Goodman WK (1990) Obsessive-compulsive disorder: recent neurobiological developments. Curr Opin Psychiatry 3:239–244
Meyendorff E, Jain A, Träskman-Bendz L, Stanley B, Stanley M (1986) The effects of fenfluramine on suicidal behavior. Psychopharmacol Bull 22:155–159
Miczek KA, DeBold JF (1983) Hormone-drug interactions and their influence on aggressive behavior. In: Svare BB (ed) Hormones and aggressive behavior. Plenum Press, New York, pp 313–347
Miczek KA, Donat P (1989) Brain 5-HT systems and inhibition of aggressive behavior. In: Bevan P, Cool A, Archer T (eds) Bevioural pharmacology of 5-HT. Lawrence Erlbaum, Hillsdale, NJ, pp 117–144
Miczek KA, Mos J, Olivier B (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol Bull 25:399–403
Montgomery SA (1980) Clomipramine in obsessional neurosis: A placebo controlled trial. Pharmacol Med 1:189–192
Morand C, Young SN, Ervin FR (1983) Clinical response of aggressive schizophrenics to oral trypthophan. Biol Psychiatry 18:575–578
Mühlbauer HD (1985) Human aggression and the role of central serotonin. Pharmacopsychiatry 18:218–221
Mühlbauer HD, Müller-Oerlinghausen B (1985) Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: Further evidence for a central serotonergic action of lithium in man. J Neural Transm 61:81–94
Müller-Oerlinghausen B (1985) Lithium long term treatment. Does it act via serotonin? Pharmacopsychiatry 18:214–217
Müller-Oerlinghausen B (1989) Pharmakotherapie pathologischen aggressiven und autoaggressiven Verhaltens. In: Pöldinger W, Wagner W (Hrsg) Aggression, Selbstaggression, Familie und Gesellschaft. Springer, Berlin Heidelberg New York Tokyo, s 121–134
Olivier B, Mos J, Tulp M, Schipper J, Bevan P (1989) Modulatory action of serotonin in aggressive behavior. In: Bevan P, Cools A, Archer T (eds) Behavioural pharmacology of 5-HT. Lawrence Erlbaum, Hillsdale, NJ, pp 89–115
Orzack MH, Friedman LM, Marby DW (1990) Weight changes on fluoxetine as a function of baseline weight in depressed outpatients. Psychopharmacol Bull 26:327–330
Osterheider M (1990) 5-HT receptors and anxiety. J Affective Disord 18 (Suppl):38–41
Osterheider M (1991a) Neurological and psychometric findings in OCD. Psychiatry Res (in press)
Osterheider M (1991b) Buspirone augmentation in fluoxetine treated OCD-patients. Pharmacopsychiatry (in press)
Osterheider M, Lettmaier D (1991) Die Zwangserkrankung — Differentialdiagnose und Therapie. Nervenarzt (im Druck)
Osterheider M, Lettmaier D, Beckmann H (1990) Basal ganglia disturbances in obsessive compulsive disorder. In: APA Proceedings, 143rd Animal Meeting. New Research Publ., New York, p 80
Parent A, Poitras D, Dube L (1984) Comparative anatomy of central monoaminergic systems. In: Björklund A, Hökfelt T (eds) Handbook of chemical neuroanatomy, Vol 2: Classical transmitters in the CNS, Part I. Elsevier, Amsterdam, pp 409–439
Peroutka SJ (1988) 5-Hydroxytryptamine receptor subtypes: Molecular, biochemical and physiological characterization. Trends Neurosci 11:496–500
Perse TL, Greist JH, Jefferson JW, Rosenfeld R, Dar R (1988) Fluvoxamine treatment of obsessive-compulsive disorder. Am J Psychiatry 144:1543–1548
Peters UH (1990) Wörterbuch der Psychiatrie und medizinischen Psychologie. Urban & Schwarzenberg, München
Pucilowski O, Kostowski W (1983) Aggressive behavior and the central serotonergic system. Behav Brain Res 9:33–48
Raleigh MJ, McGuire MT, Brammer GL, Yuwiler A (1984) Social and environmental influence on blood serotonin concentrations in monkeys. Arch Gen Psychiatry 41:405–410
Rapoport JL (1989) The new biology of obsessive-compulsive disorder. Sci Am 260(3):82–89
Rapoport JL (1991) Medikamentöse Behandlung der Zwangserkrankung. Nervenarzt 62:318–320
Rapoport JL, Wise SP (1988) Obsessive-compulsive disorder: evidence for basal ganglia dysfunction. Psychopharmacol Bull 24:380–384
Scott JP (1958) Aggression. The University of Chicago Press, Chicago
Stahl SM (1988) Basal ganglia neuropharmacology and obsessive-compulsive disorder: The obsessive-compulsive disorder hypothesis of basal ganglia dysfunction. Psychopharmacol Bull 24:370–374
Swedo SE, Rapoport JL, Cheslow DL, Leonhard HL, Ayoub EM, Hosier DM, Wald ER (1989) High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea. Am J Psychiatry 146:2
Thoren P, Asberg M, Cronholm B, Jornestedt L, Traskman L (1980) Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. Arch Gen Psychiatry 37:1281–1285
Virkkunen M, Nuutila A, Goodwin FK, Linnoila M (1987) CSF monoamine metabolites in male arsonists. Arch Gen Psychiatry 44:241–247
Wakelin JS (1988) The role of serotonine in depression and suicide. Do serotonine reuptake inhibitors provide a key? Adv Biol Psychiatry 17:70–83
Weilburg JB, Mesulam MM, Weintraub S, Buonanno F, Jenike M, Stakes JW (1989) Focal striatal abnormalities in a patient with obsessive-compulsive disorder. Arch Neurol 46:233–235
Westphal K (1878) über Zwangsvorstellungen. Arch Psychiatr Nervenkr 8:734–750
Wickham EA, Reed JV (1987) Lithium for the control of aggressive and self-mutilating behavior. Int J Clin Psychopharmacol 2:181–190
Zohar J, Mueller EA, Insel TR, Zohar-Kadouch RC, Murphy DL (1987) Serotonergic responsitivity in obsessive-compulsive disorder: comparison of patients and healthy controls. Arch Gen Psychiatry 44:946–951
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Osterheider, M. (1991). Zwang und Störungen der Impulskontrolle. In: Beckmann, H., Osterheider, M. (eds) Neurotransmitter und psychische Erkrankungen. Tropon-Symposium VI, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84544-4_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-84544-4_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-54220-9
Online ISBN: 978-3-642-84544-4
eBook Packages: Springer Book Archive