Zusammenfassung
Nach der Einführung der ersten effizienten antipsychotischen und antidepressiven Mittel in den 50er Jahren und mit der folgenden Entdeckung, daß diese Mittel auf verschiedene Art und Wesie mit Neurotransmitterfunktionen des ZNS interferieren, nahm die Erforschung des Gehirns neue Wege. In der Tat ist die Entdeckung der neurohumoralen Übertragung als ein wichtiges Prinzip der ZNS-Funktion eng verbunden mit der Aufklärung der Wirkungsweise moderner Psychopharmaka. Weiterhin haben so die biologische Psychiatrie und die Neurologie einen gewaltigen Anstoß erhalten, und neuropsychiatrische Störungen werden nun hauptsächlich als Neurotransmitterstörungen und -Ungleichgewichte diskutiert.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:179–186
Carlsson M, Carlsson A (1989a) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J. Neural Transm 75:221–226
Carlsson M, Carlsson A (1989b) Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice. J Neural Transm 77:65–71
Carlsson M, Carlsson A (1989c) Marked locomotor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine. J Neural Transm (P-D Section) 1:317–322
Carlsson M, Svensson A (1990) Interfering with glutamatergic neurotransmission by means of MK-801 administration discloses the locomotor stimulatory potential of other transmitter systems in rats and mice. Pharmacol Biochem Behav 36:45–50
Clark D, Hjorth S, Carlsson A (1985a) Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity. I. Review of the evidence. J Neural Transm 62:1–52
Clark D, Hjorth S, Carlsson A (1985b) Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity. II. Theoretical considerations. J Neural Transm 62:171–207
Farde L, Wiesel F-A, Halldin C, Sedvall G (1988) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45:71–78
Halpain S, Girault J-A, Greengard P (1990) Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Nature 343:369–371
Heimer L, Alheid GF, Zaborszky L (1985) Basal ganglia. In: Praxinos G (ed) The rat nervous system, Vol 1: Forebrain and midbrain. Academic Press., New York, pp 37–86
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96
Nauta WJF (1989) Reciprocal links of the corpus striatum with the cerebral cortex and limbic system: A common substrate for movement and thought. In: Mueller J (ed) Neurology and psychiatry: A meeting of minds. Karger, Basel, pp 43–63
Sokoloff P, Giros B, Martres M-P, Bouthenet M-L, Schwartz J-C (1990) Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics. Nature 347:146–151
Svensson K, Hjorth S, Clark D et al. (1986a) (+)-UH 232 and (+)-UH 242: Novel stereoselective DA receptor antagonists with preferential action on autoreceptors. J Neural Transm 65:1–27
Svensson K, Johannson AM, Magnusson T, Carlsson A (1986b) (+)-AJ 76 and (+)-UH 232: Central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol 334:234–245
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Carlsson, A. (1991). Das antipsychotische Potential von dopaminergen Liganden. In: Beckmann, H., Osterheider, M. (eds) Neurotransmitter und psychische Erkrankungen. Tropon-Symposium VI, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84544-4_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-84544-4_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-54220-9
Online ISBN: 978-3-642-84544-4
eBook Packages: Springer Book Archive