Carcinogenic Drugs and their Relevance in Risk Assessment
Today drug-induced effects and diseases are gaining in significance because the number of drugs and their uses are increasing constantly (Schmähl & Habs 1980). Meanwhile induction of cancer in human beings by medical treatment has been described frequently although the detection of carcinogenic activity of a drug often turns out to be problematic. On the one hand the induction time of a drug-induced carcinoma usually takes many years or even decades wherefore it is almost impossible to trace back the cause of the carcinoma on the other hand treatment with drugs often is a combination of several drugs and not a monotherapy what makes it difficult to attribute the carcinogenic action to one certain drug. However, more and more drugs have been suspected to act carcinogenicly (Table 1) and it is known from the observation of clinical cases, from epidemiological studies as well as from animal experiments which drugs or drug groups have to be regarded as potentially carcinogenic for man (Schmähl 1981).
KeywordsLeukemia Psoriasis Chinoline Adriamycin Streptozotocine
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