Carcinogenic Drugs and their Relevance in Risk Assessment
Today drug-induced effects and diseases are gaining in significance because the number of drugs and their uses are increasing constantly (Schmähl & Habs 1980). Meanwhile induction of cancer in human beings by medical treatment has been described frequently although the detection of carcinogenic activity of a drug often turns out to be problematic. On the one hand the induction time of a drug-induced carcinoma usually takes many years or even decades wherefore it is almost impossible to trace back the cause of the carcinoma on the other hand treatment with drugs often is a combination of several drugs and not a monotherapy what makes it difficult to attribute the carcinogenic action to one certain drug. However, more and more drugs have been suspected to act carcinogenicly (Table 1) and it is known from the observation of clinical cases, from epidemiological studies as well as from animal experiments which drugs or drug groups have to be regarded as potentially carcinogenic for man (Schmähl 1981).
KeywordsNatl Cancer Inst Alkylating Agent Renal Pelvis Induction Time Carcinogenic Effect
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- DeVita VT, Arseneau JC, Sherins RJ, Canellos GP, Young RC (1973) Intensive chemotherapy for Hodgkin’s disease: Long-term complications, in: Natl Cancer Inst Monograph 36, pp 447–454.Google Scholar
- Ehlers G (1968) Klinische und histologische Untersuchungen zur Frage arzneimittelbedingter Arsen-Tumoren. Zschr Haut Geschl Krkh 43, 18: 763–774.Google Scholar
- Hutchinson J (1905) On some examples of arsenic keratosis of the skin and arsenic cancer. Tr Path Soc (London) 39: 277.Google Scholar
- IARC — International Agency for Research on Cancer (1980) Some pharmacological drugs. IARC Monogr Eval Carcinog Risk Chem Hum (Suppl) 24:135–161.Google Scholar
- Paris JA (1820) Pharmacologica Ed 3, pp 132–134, London: Phillips 1820.Google Scholar
- Schmähl D (1990) Carcinogenic effects of immunosuppressive drugs in man, in: De novo cancers in organ transplant patients, Penn I and Schmähl D (eds), Springer Verlag Heidelberg, in press.Google Scholar
- Schmähl D, Habs M (1980) Drug-induced cancer, in: Current topics in Pathology, Volume 69, Drug-Induced Pathology, edited by: E. Grundmann, Springer Verlag Berlin Heidelberg.Google Scholar
- Schmähl D, Kaldor JM (ed) (1986) Carcinogenicity of alkylating cytostatics drugs. IARC Sci Publ 78, IARC Lyon.Google Scholar
- Schmähl D, Osswald H (1970) Experimentelle Untersuchungen über die carcinogenen Wirkungen von Krebschemotherapeutika und Immunsuppressiva. Arzneim Forsch (Drug Res) 20: 1461–1467.Google Scholar