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Excitotoxicity and Neuropsychiatric Disorders

  • Conference paper
Glutamate, Cell Death and Memory

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

Three decades ago, Curtis and Watkins (1963), using newly developed micro-electrophoretic techniques to examine the membrane-depolarizing properties of glutamate (Glu) and related compounds, characterized the structural requirements for molecular interaction with an apparent excitatory amino acid (EAA) receptor. However, the myriad metabolic involvements of Glu, its ability to excite neurons throughout the central nervous system (CNS) and the lack of any known mechanism for terminating its excitatory action led neuroscientists of the 1960s and 1970s to reject Glu as a transmitter candidate. This view has yielded slowly to evidence that Glu satisfies the criteria for a transmitter and today this common acidic amino acid is widely accepted as the front-running transmitter candidate at the majority of excitatory synapses in the mammalian CNS.

Supported in part by NIMH Research Scientist Award MH 38894 (JWO) and HHS grants HD 24237, DA 05072 and AG 05681

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References

  • Aizenman E, White WF, Loring RH, Rosenberg PA (1989). Dopamine-related substance acts as a glutamatergic agonist. Soc. Neurosci. Abstr., 15, 768.

    Google Scholar 

  • Arendash GW, Millard WJ, Dunn AJ, Meyer EM (1987). Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat. Science 238:952–956.

    Article  PubMed  CAS  Google Scholar 

  • Auer RN (1985). Hypoglycemic brain damage. An experimental neuropathologic study in the rat. Doctoral thesis, Studentlitteratur, University of Lund.

    Google Scholar 

  • Auer RN, Kalimo H, Olsson Y, Siesjo BK (1985). The temporal evolution of hypoglycemic brain damage: II. Light and electron microscopic findings in the rat hippocampus. Acta Neuropathol (Berl) 67:25–36.

    CAS  Google Scholar 

  • Beal MF, Kowall NW, Ellison DW, Mazurek MF, Swartz KJ, Martin JB (1986). Replication of the neurochemical characteristics of Huntington’s disease by quinolinic acid. Nature 6066:168–171.

    Article  Google Scholar 

  • Benveniste H, Drejer J, Schousboe A, Diemer NM (1984). Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369–1374.

    Article  PubMed  CAS  Google Scholar 

  • Biscoe, TJ, Evans RH, Headley PM, Martin MR, Watkins JC (1976). Structure-activity relations of excitatory amino acids on frog and rat spinal neurones. Br. J. Pharmacol. 58:373–382.

    PubMed  CAS  Google Scholar 

  • Campochiaro P, Coyle JT (1978). Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation. Proc Natl Acad Sci 75:2025–2029.

    Article  PubMed  CAS  Google Scholar 

  • Carter C, Benavides J, Legendre P, Vincent JD, Noel F, Thuret F, Lloyd KG, Arbilla S, Zivkovic B, MacKenzie ET, Scatton B, Langer SZ (1988) Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties. J Pharmacol Exp Ther 247:1222–1232.

    CAS  Google Scholar 

  • Clifford DB, Zorumski CF, Olney JW (1989). Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures. Exp Neurol 105, 272–279.

    Article  PubMed  CAS  Google Scholar 

  • Clifford DB, Olney JW, Benz AM, Fuller TA, Zorumski CF (1990) Ketamine, phencyclidine and MK-801 protect against KA induced seizure-related brain damage. Epilepsia 31:382–390.

    Article  PubMed  CAS  Google Scholar 

  • Collins RC, Olney JW (1982) Focal cortical seizures cause distant thalamic lesions. Science 218, 177–179.

    Article  PubMed  CAS  Google Scholar 

  • Corsellis JAN (1978). Posttraumatic dementia. In: Katzman R, Terry RD, Bick KL (eds) Alzheimer’s disease: senile dementia and related disorders. New York; Raven Press, pp 125–133.

    Google Scholar 

  • Cowburn R, Hardy J, Roberts P, Briggs R (1988). Presynaptic and postsynaptic glutamatergic function in Alzheimer’s disease. Neurosci Lett 86:109–113.

    Article  PubMed  CAS  Google Scholar 

  • Coyle JT, McGeer EF, McGeer PL, Schwarcz R (1978). Neostriatal injections: A model for Huntington’s chorea. In: McGeer EG, Olney JW, McGeer PL (eds) Kainic acid as a tool in neurobiology. New York, Raven Press, pp 139–159.

    Google Scholar 

  • Coyle JT, Price DL, De Long MA (1983). Alzheimer’s disease: A disorder of cortical cholinergic innervation. Science 219:1184–1190.

    Article  PubMed  CAS  Google Scholar 

  • Curtis DR, Watkins JC (1963) Acidic amino acids with strong excitatory actions on mammalian neurons. J Physiol 166:1–14.

    PubMed  CAS  Google Scholar 

  • Davies SN, Lester RAI, Reyman KG, Collinridge GL (1989). Temporally distinct pre and post synaptic mechanisms maintain long term potentiation. Nature 338:500–503.

    Article  PubMed  CAS  Google Scholar 

  • De Boni U, McLachlan DRC (1985). Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons by glutamate and aspartate. J Neurol Sci 68:105–118.

    Article  PubMed  Google Scholar 

  • Debonnel GL, Beauchesne GL, DeMontigny C (1989). Domoic acid, the alleged “mussel toxin”, might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the rat dorsal hippocampus. Can. J. Physiol. Pharmacol. 67:29–33.

    Article  PubMed  CAS  Google Scholar 

  • Faden AI, Simon RP (1987). N-methyl-D-aspartate receptor antagonist MK-801 improves outcome following experimental spinal cord injury in rats. Neurosci Abst 13:1031.

    Google Scholar 

  • Faden AI, Demediuk S, Panter S, Vink R (1989). The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798–800.

    Article  PubMed  CAS  Google Scholar 

  • Ferrante RJ, Kowall NW, Beal MF, Richardson EP Jr., Bird ED, Martin JB (1985). Selective sparing of a class of striatal neurons in Huntington’s disease. Science 230:561–563.

    Article  PubMed  CAS  Google Scholar 

  • Gill R, Foster AC, Woodruff GN (1987). Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J Neurosci 7:3343–3349.

    PubMed  CAS  Google Scholar 

  • Goldberg MP, Pham P, Choi DW (1987) Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture. Neurosci Lett 80:11–15.

    Article  PubMed  CAS  Google Scholar 

  • Greenamyre TJ, Penny JB, D’Amato CJ, Young AB (1987). Dementia of the Alzheimer’s type: changes in hippocampal L-[3H] glutamate binding. J. Neurochem 48:543–551.

    Article  PubMed  CAS  Google Scholar 

  • Hayes RL, Chapouris R, Lyeth BG, Jenkins L, Robinson SE, Young HF, Marmarou A (1987). Pretreatment with phencyclidine (PCP) attenuates long-term behavioral deficits following concussive brain injury in the rat. Neurosci Abst 13:1254.

    Google Scholar 

  • Heafield MT, Fearn S, Steventon GB, Waring RH, Williams AD, Sturman SG (1990) Plasma cysteine and sulphate levels in patients with motorneurone, Parkinson’s and Alzheimer’s disease. Neurosci Lett 110:216–220.

    Article  PubMed  CAS  Google Scholar 

  • Heyes MP (1990). Quinolinic acid and kynurenic acid: Potential mediators of neuronal dysfunction in infectious disease. Neurochem Internat 16:9.

    Google Scholar 

  • Honore T, Davies SN, Drejer J, Fletcher EJ, Jacobsen P, Lodge D, Nielsen FE (1988). Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701–703.

    Article  PubMed  CAS  Google Scholar 

  • Ikonomidou C, Price MT, Mosinger JL, Frierdich G, Labruyere J, Shahid Salles K, Olney JW (1989a) Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain. J Neurosci 9:1693–1700.

    PubMed  CAS  Google Scholar 

  • Ikonomidou C, Mosinger JL, Shahid Salles K. Labruyere J, Olney JW (1989b) Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity. J Neurosci 9:2809–2818.

    PubMed  CAS  Google Scholar 

  • Izumi Y, Miyakawa H, Ito K, Kato H (1987). Quisqualate and N-methyl-D-aspartate receptors in induction of hippocampal long term facilitation using conditioning solution. Neurosci. Lettr. 83:201–206.

    Article  CAS  Google Scholar 

  • Johnson JW, Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325:529–531.

    Article  PubMed  CAS  Google Scholar 

  • Kemp JA, Foster, AC, Wong EHF (1987) Non-competitive antagonists of excitatory amino acid receptors. TINS 10:294–99.

    CAS  Google Scholar 

  • Kemp JA, Foster, AC, Leeson PD, Priestley T, Tridgett R, Iversen LL, Woodruff GNS (1988). 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci USA 85:6547–6550.

    Article  PubMed  CAS  Google Scholar 

  • Katayama Y, Cheung MK, Gorman L, Tamura T, Becker DP (1988). Increase in extracellular glutamate and associated massive ionic fluces following concussive brain injury. Neurosci Abst 14:1154.

    Google Scholar 

  • Kochhar A, Zivin JA, Lyden PD, Mazzarella V (1988). Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia. Arch Neurol 45:148–153.

    Article  PubMed  CAS  Google Scholar 

  • Koh J-Y, Goldberg MP, Hartley DM, Choi DW (1990). Non-NMDA receptor-mediated neurotoxicity in cortical culture. J. Neurosci. 10:693–705.

    PubMed  CAS  Google Scholar 

  • Labruyere J, Fuller TA, Olney JW, Price MT, Zorumski C, Clifford D (1986). Phencyclidine and ketamine protect against seizure-related brain damage. Neurosci Abst 12:344.

    Google Scholar 

  • Lampert PW, Gajdusek DC, Gibbs CJ (1972). Subacute spongiform virus encephalopathies. Am J Pathol 68:626–646.

    PubMed  CAS  Google Scholar 

  • Langlais PJ, Mair RG (1990). Protective effects of the glutamate antagonist MK-801 on pyrithiamine-induced lesions and amino acid changes in rat brain. J. Neurosci. 10(5), 1664–1674.

    PubMed  CAS  Google Scholar 

  • Lodge D, Anis NA. (1982) Effects of phenyclidine on excitatory amino acid activation of spinal interneurons in the cat. Eur J Pharmacol 77:203–204.

    Article  PubMed  CAS  Google Scholar 

  • Lodge D, Aram JA, Church J, Davies SN, Martin D, O’Shaughnessy CT, Zeman S (1987). Excitatory amino acids and phencyclidine-like drugs. In: Hicks TP, Lodge D, McLennan H, (eds). Excitatory amino acid transmission. New York, Alan R. Liss, pp 83–90.

    Google Scholar 

  • Lucas DR, Newhouse JP (1957). The toxic effect of sodium L-glutamate on the inner layers of the retina. AMA Arch Ophthalmol 58:193–201.

    Article  PubMed  CAS  Google Scholar 

  • MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL (1986). NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321:519–522.

    Article  PubMed  CAS  Google Scholar 

  • Martin JB, Kowall NW, Ferrante RJ, Cipolloni PB, Beal MF (1987). Differential sparing of NADPH-diaphorase neurons in quinolinic lesioned rat and primate striatum. Neurosci Abst 14:1030.

    Google Scholar 

  • Masters CL, Kakulas BA, Alpers MP, Gajdusek DC, Gibbs CJ (1976). Preclinical lesions and their progression in the experimental spongiform encephalopathies (Kuru and Creutzfeldt-Jakob disease) in primates. J Neuropathol Exp Neurol 35:593–605.

    Article  PubMed  CAS  Google Scholar 

  • Maura G, Barzizza A, Lottero P, Raiteri M (1990). The excitatory amino acid-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release. Neurochem. Internat., 16, 53.

    Google Scholar 

  • Mayer ML, Westbrook GL, Guthrie PB (1984). Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309:261–263.

    Article  PubMed  CAS  Google Scholar 

  • McDonald JW, Silverstein FS, Johnston MV (1987). MK-801 protects the neonatal brain from hypoxic-ischemic damage. Eur J Pharmacol 140:359–361.

    Article  PubMed  CAS  Google Scholar 

  • McDonald JW, Silverstein FS, Johnston MV (1988). NMDA neurotoxicity in 7 D.O. rats offers an in vivo model to rapidly screen neuroprotective drugs: Neuroprotective effects of MK-801 and related compounds. Neurochem Internat 12:37.

    Google Scholar 

  • McDonald JW, Trescher WH, Johnston MV (1990) The pattern and degree of selective vulnerability to excitotoxic brain injury in vivo is dependent upon developmental age. NCI 16, Suppl 1:53.

    Google Scholar 

  • Mosinger JL, Olney JW (1989a) Photothrombosis-induced ischemic neuronal degeneration in the rat retina. Exp Neurol 105:110–113, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Mosinger JL, Olney, JW (1989b) Combined treatment with MK-801 and CNQX prevents ischemic neuronal degeneration in the in vivo rat retina. Neurosci Abst 15:45.

    Google Scholar 

  • Mosinger JL, Price MT, Bai HY, Xiao H, Wozniak DF, Olney JW (1990) Blockade of both NMDA and non — NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina. Exp Neurol, in press.

    Google Scholar 

  • Mudd SH, Irreverre F, Laster L (1967). Sulfite oxidase deficiency in man: demonstration of the enzymatic defect. Science 156:1599–1602.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW (1969a). Glutamate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol 28:455–474.

    CAS  Google Scholar 

  • Olney JW (1969b). Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 164:719–721.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW (1971). Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: an electron microscopic study. J Neuropathol Exp Neurol 30:75–90.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW (1984). Excitotoxic food additives-relevance of animal studies to human safety. Neurobehav Toxicol Teratol 6:455–462.

    PubMed  CAS  Google Scholar 

  • Olney JW (1987) Food additives, excitotoxic. In: Adelman G (eds) Encyclopedia of neuroscience. Boston, Birkhauser, pp 436–438.

    Google Scholar 

  • Olney JW (1988a). Endogenous excitotoxins and neuropathological disorders. In: Lodge D, (ed) Excitatory amino acids in health and disease. England, John Wiley & Sons Ltd, pp 337–351.

    Google Scholar 

  • Olney JW. (1988b) Revelations in excitotoxicology: What next? In: Cavalheiro E.A., Lehmann J., Turski, L. (eds) Frontiers in excitatory amino acid research N.Y. Alan R. Liss, Inc., pp 589-596.

    Google Scholar 

  • Olney JW, Ho OL, Rhee V (1971). Cytotoxic effects of acidic and sulphur and sulphur-containing amino acids on the infant mouse central nervous system. Exp Brain Res 14:61–76.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Sharpe LG, Feigin RD (1972a). Glutamate-induced brain damage in infant primates. J Neuropathol Exp Neurol 31:464–488.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Ho OL, Rhee V, Schainker B (1972b) Cysteine-induced brain damage in infant and fetal rodents. Brain Res 45:309–313.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Misra CH, deGubareff T (1975). Cysteine-S-sulfate: brain damaging metabolite in sulfite oxidase deficiency. J Neuropathol Exp Neurol 34:167–176.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Misra CH, Rhee V (1976). Brain and retinal damage from the lathyrus excitotoxin, b-N-oxalyl-L-ab diaminopropionic acid (ODAP). Nature 264:659–661.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, deGubareff T, Labruyere J (1979). a-Aminoadipate blocks the neurotoxic action of N-methylaspartate. Life Sci 25:537–540.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Labruyere J, Collins JF, Curry K (1981). D-Aminophosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity. Brain Res 221:207–210.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, deGubareff T, Sloviter RS. (1983) “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology. Brain Res Bull 10:699–712.

    CAS  Google Scholar 

  • Olney JW, Collins RC, Sloviter RS (1968a). Excitotoxic mechanisms of epileptic brain damage. In: Delgado-Escueta AV, Ward AA, Woodbury DM and Porter RJ (eds). Basic mechanisms of the epilepsies: molecular and cellular approaches. New York, Raven Press, pp 857–878.

    Google Scholar 

  • Olney JW, Price MT, Fuller TA, Labruyere J, Samson L, Carpenter M, Mahan K (1989b). The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics. Neurosci Lett 68:29–34.

    Article  Google Scholar 

  • Olney J, Price M, Shahid Salles K, Labruyere J, Frierdich G (1987a). MK-801 powerfully protects against N-methyl aspartate neurotoxicity. Eur J Pharmacol 141:357–361.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Price MT, Labruyere J, Shahid Salles K, Frierdich G, Mueller M, Silverman E (1987b). Anti-parkinsonian agents are phencyclidine agonists and N-methyl aspartate antagonists. Eur J Pharmacol 142:319–320.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Ikonomidou C, Mosinger J, Shahid Salles K, Frierdich G (1988b). Role of the N-methyl aspartate receptor in developmental psychoneuropathology. Neurosci Abst 14:417.

    Google Scholar 

  • Olney JW, Ikonomidou C, Mosinger JL, Frierdich G (1989). MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain. J Neurosci 9:1701–1704.

    PubMed  CAS  Google Scholar 

  • Olney JW, Zorumski C, Price MT, Labruyere J (1990a) L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin. Science 248:596–599.

    Article  PubMed  CAS  Google Scholar 

  • Olney JW, Zorumski CF, Stewart GR, Price MT, Wang G, Labruyere J (1990b) Excitotoxicity of L-DOPA and 6-OH-DOPA: Implications for Parkinson’s and Huntington’s diseases. Exp Neurol 108:269–272.

    Article  PubMed  CAS  Google Scholar 

  • Park CK, Nehls DG, Graham DI, Teasdale GM, McCulloch J (1988) Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia. J Cereb Blood Flow Metab 8:757–762.

    Article  PubMed  CAS  Google Scholar 

  • Park C, Nehls DG, Ozyurt E, Graham DI, McCulloch J (1987). Ischemic brain damage is reduced by systemic administration of the N-methyl-D-aspartate (NMDA) antagonist, MK-801. Neurosci Abst 13:1029.

    Google Scholar 

  • Perl TM, Bedard L, Kosatsky T, Hockin JC, Todd ECD, Remis RS (1990). An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N. Eng. J. Med., 322, 1775–1780.

    Article  CAS  Google Scholar 

  • Plaitakis A, Caroscio JT (1987). Abnormal glutamate metabolism in amyotrophic lateral sclerosis. Ann Neurol 22:575–579.

    Article  PubMed  CAS  Google Scholar 

  • Plaitakis A, Nicklas WJ, Desnick RJ (1980). Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome. Ann Neurol 7:297–303.

    Article  PubMed  CAS  Google Scholar 

  • Plaitakis A, Berl S, Yahr MD (1982). Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder. Science 216:193–196.

    Article  PubMed  CAS  Google Scholar 

  • Plaitakis A, Berl S, Yahr M (1984). Neurological disorders associated with deficiency of glutamate dehydrogenase. Ann Neurol 15:144–153.

    Article  PubMed  CAS  Google Scholar 

  • Pomara N, Deptula D, Singh R, LeWitt PA, Banay Schwartz M. (1990). Excitatory amino acid concentrations in CSF of patient with Alzheimer’s disease. Biol. Psychiat 27:91A.

    Google Scholar 

  • Procter AW, Palmer AM, Francis PT, Lowe SL, Neary D, Murphy E, Doshi R, Bowen DM (1988). Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer’s disease. J Neurochem 50:790–801.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds GP, Pearson SJ, Halket J, Sandier M (1988). Brain quinolinic acid in Huntington’s Disease. J Neurochem 50:1959–1960.

    Article  PubMed  CAS  Google Scholar 

  • Ross SM, Seelig M, Spencer PS (1987). Specific antagonism of excitotoxic action of uncommon amino acids assayed in organotypic mouse cortical cultures. Brain Res 425:120–127.

    Article  PubMed  CAS  Google Scholar 

  • Rothman SM (1984). Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J Neurosci 4:1884–1891.

    PubMed  CAS  Google Scholar 

  • Rothman SM (1985). Excitatory amino acid neurotoxicity is produced by passive chloride influx. J Neurosci 6:1483–1489.

    Google Scholar 

  • Rowlands GJ, Roberts PJ. (1980). Activation of dopamine receptors inhibits calcium-dependent glutamate release from cortico-striatal terminals in vitro. Eur J. Pharmacol. 62:241–247.

    Article  PubMed  CAS  Google Scholar 

  • Sandberg M, Butcher SP, Hagberg H. (1986). Extracellular overflow of neuroactive amino acids during severe insulin-induced hypoglycemia: in vivo dialysis of the rat hippocampus. J. Neurochem. 47:178–184.

    Article  PubMed  CAS  Google Scholar 

  • Schwarcz R, Kohler C (1983). Differential vulnerability of central neurons of the rat to quinolinic acid. Neurosci Lett 38:85–90.

    Article  PubMed  CAS  Google Scholar 

  • Sheardown MJ, Nielsen EO, Hansen AJ, Jacobsen P, Honore T (1990) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia. Science 247:571–574.

    Article  PubMed  CAS  Google Scholar 

  • Simon RP, Swan JH, Griffiths T, Meldrum BS (1984). Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226:850–852.

    Article  PubMed  CAS  Google Scholar 

  • Sloviter RS (1983). “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res Bull 10:675–697.

    CAS  Google Scholar 

  • Somalia PK, Nicklas WJ, Heikkila Re (1989). Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science 243:398–400.

    Article  Google Scholar 

  • Spencer PS, Schaumburg HH, Cohn DF, Seth PK(1984). Lathyrism: a useful model of primary lateral sclerosis. In: Rose FC (ed) Research Progress in Motor Neurone Disease. London; TPitman, pp 312–327.

    Google Scholar 

  • Spencer PS, Ludolph A, Dwived MP, Roy DN, Hugon J, Schaumburg HH (1986). Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 1066-1067.

    Google Scholar 

  • Spencer PS, Nunn PB, Hugon J, Ludolph AC, Ross SM, Roy DN, Robertson RC (1987). Guam amyotrophic lateral sclerosis-Parkinsonism-dementia linked to a plant excitant neurotoxin. Science 237:517–522.

    Article  PubMed  CAS  Google Scholar 

  • Stewart GR, Zorumski CF, Price MT, Olney JW (1990). Domoic acid: A dementia-inducing excitotoxic food poison with KA receptor specificity. Exp Neurol, in press.

    Google Scholar 

  • Teitelbaum JS, Zatorre RJ, Carpenter S, Gendron D, Evans AC, Gjedde A, Cashman NR (1990). Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. N. Engl J. Med., 322, 1781–1787.

    Article  PubMed  CAS  Google Scholar 

  • Thal LJ, Mandel RJ, Terry RD, Buzsaki G, Gage FH (1990). Nucleus basalis lesions fail to induce senile plaques in the rat. Exp. Neurol 108:88–90.

    Article  PubMed  CAS  Google Scholar 

  • Tryphonas L, Iverson F (1990). Neuropathology of excitatory neurotoxins: the domoic acid model. Toxicol Pathol 18:165–169.

    Article  PubMed  CAS  Google Scholar 

  • Tryphonas L, Truelove J, Nera E, Iverson F (1990). Acute neurotoxicity of domoic acid in the rat. Toxicol Pathol 18:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Wang GJ, Labruyere J, Price MT, Olney W (1990) Extreme sensitivity of infant animals to glutamate toxicity: Role of NMDA receptors. Neurosci Abst, in press.

    Google Scholar 

  • Watkins JC (1978). Excitatory amino acids: In: McGeer E, Olney JW, McGeer P (eds) Kainic acid as a tool in neurobiology. New York, Raven Press, pp 37–69.

    Google Scholar 

  • Watkins JC, Evans RH (1981). Excitatory amino acid trasmitters. Ann Rev Pharmacol Toxicol 21:165–204.

    Article  CAS  Google Scholar 

  • Weiss J, Goldberg MP, Choi DW (1986). Ketamine protects cultured neocortical neurons from hypoxic injury. Brain Res 380:186–190.

    Article  PubMed  CAS  Google Scholar 

  • Weiss JH, Choi DW (1988). Beta-N-methylamino-L-alanine neurotoxicity: Requirement for bicarbonate as a cofactor. Science 241:973–975.

    Article  PubMed  CAS  Google Scholar 

  • Westbrook GL, Mayer ML (1987). Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurones. Nature 328:640.

    Article  PubMed  CAS  Google Scholar 

  • Wieloch T (1985). Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science 230:681–683.

    Article  PubMed  CAS  Google Scholar 

  • Wieloch T, Engelsen B, Westerberg E, Auer R (1985). Lesions of the glutamatergic corticostriatal projections in the rat ameliorate hypoglycemic brain damage in the striatum. Neurosci Lett 58:25–30.

    Article  PubMed  CAS  Google Scholar 

  • Young AB, Greenamyre JT, Hollingsworth Z, Albin R, D’Amato C, Shoulson I, Penney JB (1988). NMDA receptor losses in putamen from patients with Huntington’s disease. Science 241:981–983.

    Article  PubMed  CAS  Google Scholar 

  • Zeevalk G, Olynyk S, Nicklas W (1988). Excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and DIDS. Neurosci Abst 14:418.

    Google Scholar 

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  1. J. W. Olney
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Editors and Affiliations

  1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46, rue d’Ulm, F-75005, Paris, France

    Philippe Ascher Ph.D.

  2. Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Dennis W. Choi Ph.D.

  3. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen Ph.D.

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Olney, J.W. (1991). Excitotoxicity and Neuropsychiatric Disorders. In: Ascher, P., Choi, D.W., Christen, Y. (eds) Glutamate, Cell Death and Memory. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84526-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-84526-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84528-4

  • Online ISBN: 978-3-642-84526-0

  • eBook Packages: Springer Book Archive

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