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Induction and Stabilization of Long-Term Potentiation

  • Conference paper
Glutamate, Cell Death and Memory

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

A significant body of evidence implicates long-term potentiation (LTP) in the encoding of certain types of memory. LTP is triggered by very brief periods of high frequency synaptic activity, can persist unchanged for weeks (Staubli and Lynch 1987), and is selective to the connections stimulated (Lynch et. al. 1977; Andersen et. al. 1977). These are all properties expected of a memory substrate. Further correlational evidence is found in the close correspondence between the optimal stimulation parameters for inducing LTP and patterns of physiological activity occurring in hippocampus during learning. Thus, experiments using brief (30 msec) bursts of high frequency stimulation have shown that the optimal spacing between the bursts is 100–200 msec (Larson et al. 1986; Larson and Lynch 1986), which is the period of the theta EEG rhythm found in the hippocampus in animals exploring their environments (see Vanderwolf 1969 for a review). Subsequent studies recorded cell spiking bursts and rhythms in hippocampus during learning that very closely resemble the stimulation patterns found to be optimal for inducing LTP (Otto et al. 1991). It appears then that the sampling rates used by animals and the intrinsic circuitries that organize activity in hippocampus are well suited to activate chemical processes leading to LTP. The nature of the linkages between patterned physiological activity and the cellular triggers for LTP have been described (Larson and Lynch 1986, 1988).

Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92717, USA

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Authors
  1. G. Lynch
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  2. B. A. Bahr
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  3. P. W. Vanderklish
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Editors and Affiliations

  1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46, rue d’Ulm, F-75005, Paris, France

    Philippe Ascher Ph.D.

  2. Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Dennis W. Choi Ph.D.

  3. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen Ph.D.

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© 1991 Springer-Verlag Berlin Heidelberg

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Lynch, G., Bahr, B.A., Vanderklish, P.W. (1991). Induction and Stabilization of Long-Term Potentiation. In: Ascher, P., Choi, D.W., Christen, Y. (eds) Glutamate, Cell Death and Memory. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84526-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-84526-0_5

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