Skip to main content
SpringerLink
Log in

The Glutamate Receptors: Genes, Structure and Expression

  • Conference paper
Glutamate, Cell Death and Memory

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

Many plausible theories of learning, pattern recognition and memory depend upon changes in the efficiency of chemical synapses (Cajal 1911; Hebb 1949; Hopfield 1982; Kandel and Schwartz 1982). It seems unlikely that these theories will be testable until the structure, function and regulation of receptor and ion channel molecules are understood in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albin RL, Young AB, Penney JB, Handelin B, Balfour R, anderson KD, Markel DS, Tourtellotte WW, Reiner A (1989) Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington’s Disease. New Eng. J. Med. 322(18):1293–1298.

    Article  Google Scholar 

  • Bettler B, Boulter J, Hermans-Borgmeyer I, O’Shea-Greenfield A, Deneris ES, Moll C, Borgmeyer U, Hollmann M, Heinemann S (1990) Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Neuron 5:583–595.

    Article  PubMed  CAS  Google Scholar 

  • Boulter J, Connolly J, Deneris E, Goldman D, Heinemann S, Patrick J (1987) Functional expression of two neural nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. USA. 84:7763–7767.

    Article  PubMed  CAS  Google Scholar 

  • Boulter J, Hollmann M, O’Shea-Greenfield A, Hartley M, Deneris ES, Heinemann S (1990) Molecular cloning and functional expression of glutamate receptor subunit genes. Science 249:1033.

    Article  PubMed  CAS  Google Scholar 

  • Cajal SR (1911) Histologie du système nerveux de l’homme et des vertèbres. Moloine, Paris.

    Google Scholar 

  • Carlsson M, Carlsson A (1990) Interactions between glutamatergic and momoaminergic systems within basal ganglia-implications for schizophrenia and Parkinson’s disease. TINS. 13:272–276.

    PubMed  CAS  Google Scholar 

  • Claudio T, Ballivet M, Patrick J, Heinemann S (1983) Nucleotide and deduced amino acid sequences of Tropedo californica acetylcholine receptor gamma-subunit. Proc. Natl. Acad. Sci. USA. 80:1111–1115.

    Article  PubMed  CAS  Google Scholar 

  • Collingridge GL, Bliss TVP (1987) NMDA receptors — their role in long-term potentiation. TINS 10(7):288–293.

    CAS  Google Scholar 

  • Collingridge GL, Lester RAJ (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40:143–210.

    Google Scholar 

  • Deneris ES, Boulter J, Swanson LW, Patrick J, Heinemann S (1989) b3: A new member of nicotinic acetylcholine receptor gene family is expressend in brain. J. Biol. Chem. 264(11):6268–6272.

    PubMed  CAS  Google Scholar 

  • Deneris ES, Connolly J, Boulter J, Wada E, Wada K, Swanson LW, Patrick J, Heinemann S (1988) Primary structure and expression of b2: a novel subunit of neuronal nicotinic acetylcholine receptors. Neuron 1(1):45–54.

    Article  PubMed  CAS  Google Scholar 

  • Grenningloh G, Rienitz A, Schmitt B, Methfessel C, Zensen M, Beyreuther K, Gundelfinger ED, Betz H (1987) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328:215–220.

    Article  PubMed  CAS  Google Scholar 

  • Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Seeburg T, Siddique T, Mohandas TK, Becker C-M, Betz H (1990) Alpha subunit variants of the human glycine receptor: Primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9:771.

    PubMed  CAS  Google Scholar 

  • Gundersen CB, Miledi R, Parker I (1984) Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes. Proc. Royal Soc. Lond. B 221:127.

    Article  CAS  Google Scholar 

  • Hayashi T (1954) Effects of sodium glutamate on the nervous system. Keio J. Med. 3:183.

    Article  Google Scholar 

  • Hebb, DO (1949) The organization of behavior. John Wiley & Sons, Inc., New York.

    Google Scholar 

  • Hollmann M, Hartley M, Heinemann S (1991) Calcium permeability of KA-AMPA-gated ion channel glutamate receptors depends on receptor subunit composition. Science, in press.

    Google Scholar 

  • Hollmann M, O’Shea-Greenfield A, Rogers SW, Heinemann S (1989) Cloning by functional expression of a member of the glutamate receptor family. Nature. 342:643.

    Article  PubMed  CAS  Google Scholar 

  • Hollmann M, Rogers SW, O’Shea-Greenfield A, Deneris ES, Hughes TE, Gasic GP, Heinemann S (1991) The glutamate receptor GluR-K1: structure, function, and expression in the brain. Cold Spring Harbor Symposia on Quantitative Biology, in press.

    Google Scholar 

  • Hopfield JJ (1982) Neural networks and physical systems with emergent collective computational abilities. Proc. Natl. Acad. Sci. USA. 79:2554–2558.

    Article  PubMed  CAS  Google Scholar 

  • Iino M, Ozawa S, Tsuzuki K (1990) Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. 424:151–165.

    PubMed  CAS  Google Scholar 

  • Kandel ER, Schwartz JH (1982) Molecular biology of learning: modulation of transmitter release. Science 29:433–443.

    Article  Google Scholar 

  • Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105–132.

    Article  PubMed  CAS  Google Scholar 

  • Monaghan, DT, Bridges RJ, Cotman CW (1989) The excitatory amino acid receptors: then-classes, pharmacology, and distinct properties in the function of the central nervous system. Ann. Rev. Pharmacol. Toxicol 29:365.

    Article  CAS  Google Scholar 

  • Morris RGM (1989) Synaptic plasticity and learning: selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9):3040–3057.

    PubMed  CAS  Google Scholar 

  • Olney JS (1989) Excitotoxicity and N-methyl-D-aspartate receptors. Drug Dev. Res. 17:299.

    Article  CAS  Google Scholar 

  • Rao JKM, Argos P (1986) A conformational preference parameter to predict helices in integral membrane proteins. Biochim. Biophys. Acta. 869:197.

    Article  CAS  Google Scholar 

  • Schofield PR, Darlison MG, Fujita N, Burt DR, Stephenson FA, Rodriguez H, Rhee LM, Ramachandran J, Reale V, Glencorse TA, Seeburg PH, Barnard EA (1987) Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature. 328:221–227.

    Article  PubMed  CAS  Google Scholar 

  • Shivers BD, Killisch I, Sprengel R, Sontheimer H, Koohler M, Schofield PR, Seeburg PH (1989) Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 3:327.

    Article  PubMed  CAS  Google Scholar 

  • Sumikawa K, Parker I, Miledi R (1984) Partial purification and functional expression of brain mRNAs coding for neurotransmitter receptors and voltage-operated channels. Proc. Natl. Acad. Sci. USA. 81:7994.

    Article  PubMed  CAS  Google Scholar 

  • Wachtel H, Turski L (1990) Glutamate: a new target in schizophrenia. TIPS. 11:219–220.

    PubMed  CAS  Google Scholar 

  • Wada K, Ballivet M, Boulter J, Connolly J, Wada E, Deneris E, Swanson L, Heinemann S, Patrick J (1988) Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor. Science. 240:330–334.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. S. Heinemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Bettler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Boulter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Deneris
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Gasic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Hartley
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Hollmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. E. Hughes
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. O’Shea-Greenfield
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. S. Rogers
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46, rue d’Ulm, F-75005, Paris, France

    Philippe Ascher Ph.D.

  2. Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Dennis W. Choi Ph.D.

  3. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Heinemann, S. et al. (1991). The Glutamate Receptors: Genes, Structure and Expression. In: Ascher, P., Choi, D.W., Christen, Y. (eds) Glutamate, Cell Death and Memory. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84526-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84526-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84528-4

  • Online ISBN: 978-3-642-84526-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation