Excitotoxicity on Cultured Cortical Neurons

  • D. W. Choi
Conference paper
Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)

Abstract

This meeting is focused on two important properties of neurotransmitter glutamate. First, glutamate can regulate the long-term behavior of at least some of the excitatory synapses where it serves as neurotransmitter. This regulation provides a means for dynamic synaptic plasticity and may play a key role in normal functions such as memory and learning. Second, excess exposure to glutamate can destroy neurons, a process Olney (1986) called “excitotoxicity.” Excitotoxicity may contribute to pathogenesis of certain acute or chronic neurological diseases. While glutamate-mediated synaptic regulation and glutamate-mediated neuronal death occur in different settings, a theme of the present meeting is that the two processes may overlap substantially at the level of underlying mechanism.

Keywords

Toxicity Superoxide Glycine Choline Ketamine 

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© Springer-Verlag Berlin Heidelberg 1991

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  • D. W. Choi

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