Excitotoxicity on Cultured Cortical Neurons
This meeting is focused on two important properties of neurotransmitter glutamate. First, glutamate can regulate the long-term behavior of at least some of the excitatory synapses where it serves as neurotransmitter. This regulation provides a means for dynamic synaptic plasticity and may play a key role in normal functions such as memory and learning. Second, excess exposure to glutamate can destroy neurons, a process Olney (1986) called “excitotoxicity.” Excitotoxicity may contribute to pathogenesis of certain acute or chronic neurological diseases. While glutamate-mediated synaptic regulation and glutamate-mediated neuronal death occur in different settings, a theme of the present meeting is that the two processes may overlap substantially at the level of underlying mechanism.
KeywordsNMDA Receptor Cortical Neuron Excitatory Amino Acid Domoic Acid Glutamate Toxicity
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