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Radiation Therapy in Pediatric Oncology pp 265–279Cite as

Ewing’s Sarcoma

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Ewing’s sarcoma is one of a number of small-roundcell sarcomas that occur in childhood, though its exact origin continues to elude investigators. Pathologically, the best definition is that it is a tumor of small, round, blue cells, usually but not always associated with bone, that lacks markers for lymphoma, neuroblastoma, or rhabdomyosarcoma (Womer 1991). It is not yet clear whether it is a heterogeneous group of tumors that contains subgroups, or a single entity to which several other diagnoses belong. There are two different opinions regarding the origin of Ewing’s sarcoma: that it is of neuroectodermal origin, or that it arises from primitive, undifferentiated, mesenchymal cells (Womer 1991). If the latter is true, the tumor might be better regarded as a blastoma than as a true sarcoma.

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References

  • Anderson M, Green WT, Messner MB (1963) Growth and predictions of growth in the lower extremities. J Bone Joint Surg [Am] 45: 1–14

    Google Scholar 

  • Arai Y, Kun LE, Brooks MT et al. (1991) Ewing’s sarcoma: local tumor control and patterns of failure following limited-volume radiation therapy. Int J Radiat Oncol Biol Phys 21: 1501–1508

    Article  PubMed  CAS  Google Scholar 

  • Bader JL, Horowitz ME, Dewan R et al. (1989) Intensive combined modality therapy of small round cell and undifferentiated sarcomas in children and young adults: local control and patterns of failure. Radiother Oncol 16: 189–201

    Article  PubMed  CAS  Google Scholar 

  • Barbieri E, Emiliani E, Zini G et al. (1990) Combined therapy of localized Ewing’s sarcoma of bone: analysis of results in 100 patients. Int J Radiat Oncol Biol Phys 19: 1165–1170

    Article  PubMed  CAS  Google Scholar 

  • Boriani S, Picci P, Sudanese A et al. (1988) Radio-induced sarcomas in survivors of Ewing’s sarcoma. Tumori 74: 543–551

    PubMed  CAS  Google Scholar 

  • Burgert EO Jr, Nesbit ME, Garnsey LA et al. (1990) Multimodal therapy for the management of nonpelvic, localized Ewing’s sarcoma of bone: Intergroup Study IESS-II. J Clin Oncol 8: 1514–1524

    PubMed  Google Scholar 

  • Cangir A, Vietti TJ, Gehan EA et al. (1990) Ewing’s sarcoma metastatic at diagnosis: results and comparisons of two Intergroup Ewing’s Sarcoma Studies. Cancer 66: 887–893

    Article  PubMed  CAS  Google Scholar 

  • Capanna R, Toni A, Sudanese A, McDonald D, Bacci G, Campanacci M (1990) Ewing’s sarcoma of the pelvis. Int Orthop 14: 57–61

    Article  PubMed  CAS  Google Scholar 

  • Dunst J, Sauer R, Burgers JMV et al. (1991) Radiation therapy as local treatment in Ewing’s sarcoma: results of the Cooperative Ewing’s Sarcoma Studies CESS 81 and CESS 86. Cancer 67: 2818–2825

    Article  PubMed  CAS  Google Scholar 

  • Edeiken J, Karasick D (1987) Imaging in bone cancer. CA 37: 239–245

    Article  PubMed  CAS  Google Scholar 

  • Evans RG, Nesbit ME, Gehan EA et al. (1991) Multimodal therapy for the management of localized Ewing’s sarcoma of pelvic and sacral bones: a report from the Second Intergroup Study. J Clin Oncol 9: 1173–1180

    PubMed  CAS  Google Scholar 

  • Fletcher BD, Hanna SL, Kun LE (1990) Changes in MR signal intensity and contrast enhancement of therapeutically irradiated soft tissue. Magn Reson Imaging 8: 771–777

    Article  PubMed  CAS  Google Scholar 

  • Hayes FA, Thompson EI, Hustu HO, Kumar M, Coburn T, Webber B (1983) The response of Ewing’s sarcoma to sequential cyclophosphamide and adriamycin induction therapy. J Clin Oncol 1: 45–51

    PubMed  CAS  Google Scholar 

  • Hayes FA, Thompson EI, Kumar M, Hustu HO (1987) Longterm survival in patients with Ewing’s sarcoma relapsing after completing therapy. Med Pediatr Oncol 15: 254–256

    Article  PubMed  CAS  Google Scholar 

  • Hayes FA, Thompson EI, Meyer WH et al. (1989) Therapy for localized Ewing’s sarcoma of bone. J Clin Oncol 7: 208–213

    PubMed  CAS  Google Scholar 

  • Jenkin RDT, Rider WD, Sonley MJ (1976) Ewing’s sarcoma: adjuvant total body irradiation, cyclophosphamide and vincristine. Int J Radiat Oncol Biol Phys 1: 407–413

    Article  PubMed  CAS  Google Scholar 

  • Jereb B, Ong RL, Mohan M, Caparros B, Exelby P (1986) Redefined role of radiation in combined treatment of Ewing’s sarcoma. Pediatr Hematol Oncol 3: 111–118

    Article  PubMed  CAS  Google Scholar 

  • Jürgens H, Exner U, Gadner H et al. (1988) Multidisciplinary treatment of primary Ewing’s sarcoma of bone: a 6-year experience of a European cooperative trial. Cancer 61: 23–32

    Article  PubMed  Google Scholar 

  • Kinsella TJ, Glaubiger D, Diesseroth A, Makuch R, Waller B, Pizzo P, Glatstein E (1983) Intensive combined modality therapy including low-dose TBI in high-risk Ewing’s sarcoma patients. Int J Radiat Oncol Biol Phys 9: 1955–1960

    PubMed  CAS  Google Scholar 

  • Kinsella TJ, Miser JS, Triche TJ, Horvath K, Glatstein E (1988) Treatment of high-risk sarcomas in children and young adults: analysis of local control using intensive combined modality therapy. NCI Monogr 6: 291–296

    PubMed  Google Scholar 

  • Kinsella TJ, Miser JA, Waller B, Venzon D, Glatstein E, Weaver-McClure L, Horowitz ME (1991) Long-term follow-up of Ewing’s sarcoma of bone treated with combined modality therapy. Int J Radiat Oncol Biol Phys 20: 389–395

    Article  PubMed  CAS  Google Scholar 

  • Kissane JM, Askin FB, Foulkes M, Stratton LB, Shirley SF (1983) Ewing’s sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing’s Sarcoma Study. Hum Pathol 14: 773–779

    Article  PubMed  CAS  Google Scholar 

  • Ladenstein R, Lasset C, Biron P et al. (1992) The impact of megatherapy on response and survival in high-risk Ewing’s sarcoma. A report of the EBMT Solid Tumor Registry (abstract). High-dose chemotherapy and stem-cell transplant in solid tumors, an international symposium. Berlin, Society for International Oncology

    Google Scholar 

  • Marcus RB Jr (1991) Ewing’s sarcoma — a local or systemic problem? Int J Radiat Oncol Biol Phys 20: 901–902

    Article  PubMed  Google Scholar 

  • Marcus RB Jr, Million RR (1984) The effect of primary tumor size on the prognosis of Ewing’s sarcoma (abstract 24). Int J Radiat Oncol Biol Phys 10 [Suppl 2]: 88

    Google Scholar 

  • Marcus RB Jr, Graham-Pole JR, Springfield DS et al. (1988) High-risk Ewing’s sarcoma: End-intensification using autologous bone marrow transplantation. Int J Radiat Oncol Biol Phys 15: 53–59

    Article  PubMed  Google Scholar 

  • Marcus RB Jr, Cantor A, Heare TC, Graham-Pole J, Mendenhall NP, Million RR (1991) Local control and function after twice-a-day radiotherapy for Ewing’s sarcoma of bone. Int J Radiat Oncol Biol Phys 21: 1509–1515

    Article  PubMed  Google Scholar 

  • Moseley CF (1990) Leg-length discrepancy. In: Morrissy RT (ed) Lovell and Winter’s pediatric orthopaedics, 3rd edn, vol. 2. Lippincott, Philadelphia, pp 767–813

    Google Scholar 

  • Nesbit ME Jr, Gehan EA, Burgert EO Jr et al. (1990) Multimodal therapy for the management of primary, nonmetastatic Ewing’s sarcoma of bone: a long-term follow-up of the First Intergroup Study. J Clin Oncol 8: 1664–1674

    PubMed  Google Scholar 

  • Oberlin O, Patte C, Demeocq F et al. (1985) The response to initial chemotherapy as a prognostic factor in localized Ewing’s sarcoma. Eur J Cancer Clin Oncol 21: 463–467

    Article  PubMed  CAS  Google Scholar 

  • O’Connor MI, Pritchard DJ (1991) Ewing’s sarcoma: prognostic factors, disease control, and the reemerging role of surgical treatment. Clin Orthop 262: 78–87

    PubMed  Google Scholar 

  • Pendergrass TW, Foulkes MA, Robison LL, Nesbit ME (1984) Stature and Ewing’s sarcoma in childhood. Am J Pediatr Hematol Oncol 6: 33–39

    PubMed  CAS  Google Scholar 

  • Pollock BH, Krischer JP, Vietti TJ (1991) Interval between symptom onset and diagnosis of pediatric solid tumors. J Pediatr 119: 725–732

    Article  PubMed  CAS  Google Scholar 

  • Pritchard DJ (1989) Small round cell tumors. Orthop Clin North Am 20: 367–375

    PubMed  CAS  Google Scholar 

  • Sailer SL, Harmon DC, Mankin HJ, Truman JT, Suit HD (1988) Ewing’s sarcoma: surgical resection as a prognostic factor. Int J Radiat Oncol Biol Phys 15: 43–52

    Article  PubMed  CAS  Google Scholar 

  • Sauer R, Jürgens H, Burgers JMV, Dunst J, Hawlicek R, Michaelis J (1987) Prognostic factors in the treatment of Ewing’s sarcoma: the Ewing’s Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. Radiother Oncol 10: 101–110

    Article  PubMed  CAS  Google Scholar 

  • Thomas PRM, Perez CA, Neff JR, Nesbit ME, Evans RG (1984) The management of Ewing’s sarcoma: role of radiotherapy in local tumor control. Cancer Treat Rep 68: 703–710

    PubMed  CAS  Google Scholar 

  • Tucker MA, D’Angio GJ, Boice JD Jr et al. (1987) Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 317: 588–593

    Article  PubMed  CAS  Google Scholar 

  • Turc-Carel C, Aurias A, Mugneret F et al. (1988) Chromosomes in Ewing’s sarcoma: I. An evaluation of 85 cases and remarkable consistency of t(11;22) (g24;g12). Cancer Genet Cytogenet 32: 229–238

    Article  PubMed  CAS  Google Scholar 

  • Wilkins RM, Pritchard DJ, Burgert EO Jr, Unni KK (1986) Ewing’s sarcoma of bone: experience with 140 patients. Cancer 58: 2551–2555

    Article  PubMed  CAS  Google Scholar 

  • Womer RB (1991) The cellular biology of bone tumors. Clin Orthop 262: 12–21

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of Florida Health Science Center, PO Box 100385, Gainesville, FL, 32610-0385, USA

    Robert B. Marcus Jr. M.D. (Professor of Radiation Oncology and Pediatrics)

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  1. Robert B. Marcus Jr. M.D.
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Editors and Affiliations

  1. Department of Radiation Oncology, College of Medicine, The University Arizona, Health Science Center, 1501 North Campbell Ave., 85724, Tucson, AZ, USA

    J. Robert Cassady M.D. (Professor) (Professor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Marcus, R.B. (1994). Ewing’s Sarcoma. In: Cassady, J.R. (eds) Radiation Therapy in Pediatric Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84520-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-84520-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84522-2

  • Online ISBN: 978-3-642-84520-8

  • eBook Packages: Springer Book Archive

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