Skip to main content

Abstract

In histological tissue sections, monosodium urate crystals appear as collections of negative birefringent, needle-like deposits (Fig. 1 a, b). Their electron microscopic equivalent is crystals with a focal parallel arrangement of their long axes (Fig. 1 c, d). Vacuoles inside the crystals are due to the effect of the electron beam (Pritzker et al. 1978). However, the finding of these crystals in histological sections is dependent on several conditions that will be briefly discussed at the end of this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agudelo CA, Schumacher HR (1973) The synovitis of acute gouty arthritis. Hum Pathol 4: 265–279

    Article  PubMed  CAS  Google Scholar 

  • Brogsitter AM (1926) Histopathologie der Gelenkgicht. Dtsch Arch Klin Med 153: 257–326

    Google Scholar 

  • Bunim JJ, McEwen C (1940) Tophus of the mitral valve in gout. Arch Pathol 29: 700–704

    Google Scholar 

  • Canoso JJ, Yood RA (1979) Reaction of superficial bursae in response to specific disease stimuli. Arthritis Rheum 22: 1361–1364

    Article  PubMed  CAS  Google Scholar 

  • Das De S (1988) Intervertebral disc involvement in gout: brief report. J Bone Joint Surg [Br] 70: 671

    Google Scholar 

  • Farebrother DA, Hatfield P, Simmonds HA, Cameron JS, Jones AS, Cadenhead A (1975) Experimental crystal nephropathy (one year study in the pig). Clin Nephrol 4: 243–250

    Google Scholar 

  • Garrod AB (1859) The nature and treatment of gout and rheumatic gout. Walton and Maberly, London

    Google Scholar 

  • Gieseking R (1972) Elektronenoptische Befunde am Gichttophus. Therapiewoche 22: 108–113

    Google Scholar 

  • Hankin FM, Mayhew DE, Coapman RA, Snedden M, Schneider LH (1985) Gouty infiltration of a flexor tendon simulating rupture. Clin Orthop 194: 172–175

    PubMed  Google Scholar 

  • Hirohata K, Morimoto K, Kimura H (1981) Ultrastructure of bone and joint disease. Igaku-Shoin, Tokyo New York

    Google Scholar 

  • Kersley GD, Mandel L, Jeffrey MR (1950) Gout — An unusual case with softening and subluxation of the first cervical vertebra and splenomegaly. Ann Rheum Dis 9: 282–304

    Article  PubMed  CAS  Google Scholar 

  • Kirkpatrick CJ, Mohr W, Haferkamp 0 (1981) The effect of soluble sodium urate on the proliferation and proteoglycan synthesis of lapine articular chondrocytes in monolayer culture. Rheumatol Int 1: 131–133

    Article  PubMed  CAS  Google Scholar 

  • Linnane JW, Burry AF, Emmerson BT (1981) Urate deposits in the renal medulla. Prevalence and associations. Nephron 29: 216–222

    Article  PubMed  CAS  Google Scholar 

  • Mahoney PG, James PD, Howell CJ, Swannell AJ (1981) Spontaneous rupture of the achilles tendon in a patient with gout. Ann Rheum Dis 40: 416–418

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Cordero E, Barreira-Mercado E, Katona G (1986) Eye tophi deposition in gout. J Rheumatol 13: 471–472

    PubMed  CAS  Google Scholar 

  • Mohr W (1984) Arthropathien. In: Doerr W, Seifert G, Uehlinger E (eds) Pathologie der Gelenke und Weichteiltumoren I. Spezielle pathologische Anatomie Band 18/I. Springer, Berlin Heidelberg New York Tokyo (pp 373–547 )

    Google Scholar 

  • Niemi K-M (1977) Panniculitis of the leg with urate crystal deposition. Arch Dermatol 113: 655–656

    Article  PubMed  CAS  Google Scholar 

  • Palacios-Boix A, Kraus A, Alarcón-Segovia D (1984) Location of tophi at Cushing’s striae. J Rheumatol 11: 720–721

    PubMed  CAS  Google Scholar 

  • Palmer DG, Hogg N, Denholm I, Allen CA, Highton J, Hessian PA (1987) Comparison of phenotype expression by mononuclear phagocytes within subcutaneous gouty tophi and rheumatoid nodules. Rheumatol Int 7: 187–193

    Article  PubMed  CAS  Google Scholar 

  • Palmer DG, Highton J, Hessian PA (1989) Development of the gout tophus. An hypothesis. Am J Clin Pathol 91: 190–195

    PubMed  CAS  Google Scholar 

  • Pritzker KPH, Zahn CE, Nyburg SC, Luk SC, Houpt JB (1978) The ultrastructure of urate crystals in gout. J Rheumatol 5: 7–18

    PubMed  CAS  Google Scholar 

  • Sokoloff L (1957) The pathology of gout. Metabolism 6: 230–243

    PubMed  CAS  Google Scholar 

  • Traut EF, Knight AA, Szanto PB, Passerelli EW (1954) Specific vascular changes in gout. JAMA 156: 591–593

    Article  CAS  Google Scholar 

  • Uehlinger E (1976) Pathologische Anatomie der Gicht. Verh Dtsch Ges Rheumatol 4: 95–101

    PubMed  CAS  Google Scholar 

  • Virchow R (1868) Seltene Gichtablagerungen. Virchows Arch 44: 137–138

    Article  Google Scholar 

  • Zetkin M, Kühtz E-H, Fichtel K (1964) Wörterbuch der Medizin. VEB Verlag Volk und Gesundheit, Berlin

    Google Scholar 

  • Zoller WG, Füeßl HS, Löffler W, Keller C (1985) Gichttophus mit seltener Lokalisation. Munch Med Wochenschr 127: 200–201

    Google Scholar 

  • Zöllner N (1990) Die chronische Gicht: In: Zöllner N (ed) Hyperurikämie; Gicht und andere Störungen des Purinhaushaltes. Springer, Berlin Heidelberg New York London Paris Tokyo Hongkong Barcelona (pp 158–168 )

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Verlag, Berlin Heidelberg

About this paper

Cite this paper

Mohr, W. (1991). Urate Depositions in Tissues. In: Gresser, U., Zöllner, N. (eds) Urate Deposition in Man and its Clinical Consequences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84491-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84491-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84493-5

  • Online ISBN: 978-3-642-84491-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics