Cytogenetic Investigation of Gonadal Carcinomas in Situ in Syndromes of Abnormal Sexual Differentiation

  • I. Vorechovsky
  • K. Mazanec
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 123)


The development of frequently occurring gonadal tumors in some syndromes of abnormal sexual differentiation (Verp and Simpson 1987) is often preceded by carcinoma in situ (CIS) (Skakkebaek et al. 1987). Although the finding of CIS is believed to warrant gonadectomy, the CIS pattern may persist with no clinical manifestations for a very long time. To detect early changes in chromosome number and/or structure in the gonadal tissue at risk of cancer we studied the gonads of four intersex patients.


Testicular Tumor Testicular Germ Cell Tumour Tetraploid Cell Premature Chromosome Condensation Cytogenetic Investigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • I. Vorechovsky
    • 1
  • K. Mazanec
    • 2
  1. 1.Research Institute of Child HealthBrnoCzechoslovakia
  2. 2.2nd Department of PathologyChildren’s Teaching HospitalBrnoCzechoslovakia

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