Cytogenetic Investigation of Gonadal Carcinomas in Situ in Syndromes of Abnormal Sexual Differentiation
The development of frequently occurring gonadal tumors in some syndromes of abnormal sexual differentiation (Verp and Simpson 1987) is often preceded by carcinoma in situ (CIS) (Skakkebaek et al. 1987). Although the finding of CIS is believed to warrant gonadectomy, the CIS pattern may persist with no clinical manifestations for a very long time. To detect early changes in chromosome number and/or structure in the gonadal tissue at risk of cancer we studied the gonads of four intersex patients.
KeywordsRecombination Penicillin Trypsin Osteosarcoma Collagenase
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