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Analysis of Chromosome 12 Abnormalities in Male Germ Cell Cancers

  • E. Dmitrovsky
  • E. Rodriguez
  • F. Samaniego
  • V. E. Reuter
  • W. H. MillerJr.
  • N. L. Geller
  • G. J. Bosl
  • R. S. K. Chaganti
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 123)

Abstract

A specific cytogenetic abnormality, an isochromosome 12p, i(12p), has been described in male germ cell cancers (Atkin and Baker 1982, 1983). The incidence of this abnormality has been stated to be as high as 90% (Heim and Mitelman 1987), occurring in tumors histopathologically diagnosed as seminoma, nonseminoma, and teratoma (Castedo et al. 1989a,b,c; Bosl et al. 1989; Samaniego et al. 1990). Our investigations of i(12p) in human germ cell cancer provide further support for the diagnostic importance of this cytogenetic marker. This review presents the molecular and cytogenetic studies from the Memorial Sloan-Kettering Cancer Center principally concerning chromosome 12 in primary and metastatic germ cell tumors and in established germ cell cancer cell lines.

Keywords

Germ Cell Germ Cell Tumor Male Germ Cell Germ Cell Cancer Mediastinal Germ Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • E. Dmitrovsky
    • 1
  • E. Rodriguez
    • 1
  • F. Samaniego
    • 1
  • V. E. Reuter
    • 1
  • W. H. MillerJr.
    • 1
  • N. L. Geller
    • 1
  • G. J. Bosl
    • 1
  • R. S. K. Chaganti
    • 1
  1. 1.Laboratory of Molecular Medicine, Genitourinary Oncology ServiceMemorial Sloan-Kettering Cancer Center, Cornell University Medical CollegeNew YorkUSA

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