Local Intra-arterial Fibrinolysis in the Vertebrobasilar and Carotid Territories

  • Hermann Zeumer
  • F. Zanella
Part of the Medical Radiology book series (MEDRAD)


Thromboembolic occlusion of the large pial vessels is a major cause of cerebral ischemic stroke. Recanalization of such occluded vessels seems to be the most reasonable therapeutic strategy in stroke patients. However, after the introduction of streptokinase as an effective fibrinolytic agent in the 1960s, early trials to ascertain its efficacy in stroke-prone patients failed to demonstrate a reasonable benefit to risk ratio (Del Zoppo et al. 1986). On the other hand, local fibrinolysis with the aim of coronary artery re-canalization proved effective in providing high recanalization rates with less systemic hemorrhagic effects. In the cerebral arteries local intra-arterial fibrinolytic (LIF) therapy has been applied primarily in those patients commonly displaying progression of stroke, usually with a lethal outcome, e.g., patients with acute vertebrobasilar occlusion (AVBO). The prognosis of patients suffering from AVBO was shown by Hacke et al. (1988) to be improved significantly using this treatment.


Basilar Artery Sinus Thrombosis Ophthalmic Artery Deep Coma Central Retinal Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Hermann Zeumer
    • 1
  • F. Zanella
    • 1
  1. 1.Abteilung für Neuroradiologie, Radiologische KlinikUniversitätskrankenhaus Eppendorf, Universität HamburgHamburg 20Germany

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