Abstract
Nosocomial pneumonia is one of the first causes of fever in mechanically ventilated critically ill patients. Superinfection of the lung parenchyma rapidly complicates non specific alveolar damage following circulatory shock, multiple trauma and sepsis [1, 2]. Because the clinical diagnosis is difficult, the true incidence of nosocomial pneumonia is still uncertain. In a recent pathologic study, the lungs of 60 patients were histologically examined in the immediate postmortem period, and the incidence of nosocomial pneumonia was found as high as 65% [3]. It is generally agreed that critically ill patients with recent fever, increased leukocyte count, new radiologic pulmonary infiltrates and positive tracheal cultures are likely to have nosocomial pneumonia. Although very general and non specific, these clinical criterias are universally accepted and probably adequate enough to assess the incidence of nosocomial pneumonia. We recently examined the lungs of 43 patients who died in the critical care unit after demonstrating the clinical criteria of nosocomial pneumonia: 40 had disseminated foci of bronchopneumonia at microscopic examination [3]. In the mechanically ventilated critically ill, the real challenge does not concern the diagnosis itself, but rather the accurate identification of bacterias infecting the alveolar spaces. Because bronchial infection rapidly occurs within a few hours following endotracheal intubation or tracheostomy, any method designed for obtaining bacteriologic samples representative of lung parenchyma is frequently contaminated. By using markers for this bronchial contamination, uncontaminated samples can be obtained and bacteriologically analyzed. Schematically, either cell criterias or quantitative bacteriological criterias are currently used.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Seidenfeld JJ, Pohl DF, Bell RC, Harris GD, Johanson WG (1986) Incidence, site and outcome of infections in patients with the adult respiratory distress syndrome. Am Rev Resp Dis 134:12–16
Langer M, Mosconi P, Cigada M, et al. (1989) Long-term respiratory support and risk of pneumonia in critically ill patients. Am Rev Resp Dis 140:302–305
Rouby JJ, Poete P, Martin de Lassalle E, et al. (1991) Histologic and bacteriologic aspects of human nosocomial pneumonia. Am Rev Resp Dis (in press)
Wimberley MW, Faling LI, Bartlett G (1979) A fiberoptic bronchoscopy technique to obtain uncontaminated lower airway secretions for bacterial culture. Am Rev Resp Dis 119:337–343
Wimberley NW, Bass JB, Boyd BW, Kirkpatrick MB, Serio RA, Pollock HM (1982) Use of a bronchoscopy protected catheter brush for the diagnosis of pulmonary infections. Chest 81:556–562
Chastre J, Viau F, Brun K, et al. (1984) Prospective evaluation of the protected specimen brush in the diagnosis of pulmonary infections in ventilated patients. Am Rev Respir Dis 130:924–929
Johanson WG, Seidenfeld JJ, Gomez P, De Los Santos L, Coalson JJ (1988) Bacteriologic diagnosis of nosocomial pneumonia following prolonged mechanical ventilation. Am Rev Respir Dis 137:259–264
Trouillet JL, Guiguet M, Gibert C, et al. (1990) Fiberoptic bronchoscopy in ventilated patients. Evaluation of cardiopulmonary risk under midazolam sedation. Chest 97:927–933
Fagon JY, Chastre J, Hance AJ, et al. (1988) Detection of nosocomial lung infection in ventilated patients. Used of a protected specimen brush and quantitative culture techniques in 147 patients. Am Rev Respir Dis 138:110–116
Torres A, Puig de la Bellacasa J, Rodriguez-Roisin R, Jimenez de Anta MT, Agushi-Vidal A (1988) Diagnosis value of telescoping plugged catheters in mechanically ventilated patients with bacterial pneumonia using the Metras catheter. Am Rev Respir Dis 138:117–120
Rouby JJ, Rossignon MD, Nicolas MH, et al. (1989) A protected study of protected bronchoalveolar lavage in the diagnosis of nosocomial pneumonia. Anesthesiology 71:679–685
Kubota Y, Magaribuchi T, Toyoda Y, et al. (1982) Selective bronchial suctioning in the adult using a curve-tipped catheter with a guide mark. Crit Care Med 10:767–769
Kubota Y, Toyoda Y, Kubota H (1990) Blind selective bronchial catheterization. Anesthesiology 72:955–956
Thorpe JE, Baughman RP, Frame PT, Wesseler TA, Staneck JL (1987) Bronchoalveolar lavage for diagnosing acute bacterial pneumonia. J Infect Dis 155:855–861
Kahn FW, Jones JM (1987) Diagnosing bacterial respiratory infection by bronchoalveolar lavage. J Infect Dis 155:862–869
Baughman RP, Thorpe JE, Staneck J, Rashkin M, Frame PT (1987) Use of the protected specimen brush in patients with endotracheal or tracheostomy tubes. Chest 91:233–236
Salata RA, Lederman MM, Shlaes DM, et al. (1987) Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients. Am Rev Respir Dis 135:426–432
Chastre J, Fagon JY, Sder P, et al. (1988) Diagnosis of nosocomial pneumonia in intubated patients undergoing ventilation: comparison of the usefulness of bronchoalveolar lavage and the protected specimen brush. Am J Med 85:499–506
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Rouby, JJ., Poete, P., Bodin, L. (1991). The Protected Minialveolar Lavage Technique for the Diagnosis of Nosocomial Pneumonia. In: Vincent, J.L. (eds) Update 1991. Update in Intensive Care and Emergency Medicine, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84423-2_42
Download citation
DOI: https://doi.org/10.1007/978-3-642-84423-2_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53672-7
Online ISBN: 978-3-642-84423-2
eBook Packages: Springer Book Archive