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Vasodilating Therapy in ARDS

  • Conference paper
Update 1991

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 14))

  • 109 Accesses

Abstract

In patients suffering from the adult respiratory distress syndrome (ARDS), pulmonary hypertension is common event [1] and has been directly related to the severity of the lung injury [2]. This pulmonary hypertension is due to an increased pulmonary vascular resistance [1] which is caused by vascular compression [2], diffuse vasoconstriction [2] and microvascular obstruction [3].

Supported in part by the Deutsche Forschungsgemeinschaft (Fa 139/2-2).

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References

  1. Zapol WM, Snider MT (1977) Pulmonary hypertension in severe acute respiratory failure. N Engl J Med 296:476–480

    Article  PubMed  CAS  Google Scholar 

  2. Zapol WM, Jones R (1987) Vascular components of ARDS. Am Rev Respir Dis 136:471–474

    Article  PubMed  CAS  Google Scholar 

  3. Greene RD, Zapol WM, Snider MT, et al. (1981) Early bedside detection of pulmonary vascular occlusion during acute respiratory failure. Am Rev Respir Dis 124:593–601

    PubMed  CAS  Google Scholar 

  4. Brigham KL, Woolverton WC, Blake LH, Staub NC (1974) Increased sheep lung vascular permeability caused by Pseudomonas bacteremia. J Clin Invest 54:792–804

    Article  PubMed  CAS  Google Scholar 

  5. Sibbald WJ, Driedger AA, Myers ML, Short AIK, Wells GA (1983) Biventricular function in the adult respiratory distress syndrome. Chest 84:126–134

    Article  PubMed  CAS  Google Scholar 

  6. Jardin F, Farcot JC, Boisante L, Curien N, Margairaz A, Bourdarias JP (1981) Influence of positive end-expiratory pressure on left ventricular performance. N Engl J Med 304:387–392

    Article  PubMed  CAS  Google Scholar 

  7. Sibbald WJ, Driedger AA, McCallum DM, Cunningham DG, Cheung H (1986) Nitroprus-side infusion does not improve biventricular performance in patients with acute hypoxemic respiratory failure. J Crit Care 1:197–203

    Article  Google Scholar 

  8. Sibbald WJ, Short AIK, Driedger AA, Wells GA (1985) The immediate effect of isosorbide dinitrate on right ventricular function in patients with acute hypoxemic respiratory failure. Am Rev Respir Dis 131:852–868

    Google Scholar 

  9. Radermacher P, Santak B, Wüst HJ, Tarnow J, Falke KJ (1990) Prostacyclin and right ventricular function in patients with pulmonary hypertension associated with ARDS. Intensive Care Med 16:227–232

    Article  PubMed  CAS  Google Scholar 

  10. Grimbert FA (1988) Effective pulmonary capillary pressure. Eur Respir J 1:297–301

    PubMed  CAS  Google Scholar 

  11. Gaar KA, Taylor AE, Owens LJ, Guyton AC (1967) Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung. Am J Physiol 213:910–914

    PubMed  Google Scholar 

  12. Collee GG, Lynch KE, Hill RD, Zapol WM (1987) Bedside measurement of pulmonary capillary pressure in patients with acute respiratory failure. Anesthesiology 66:614–620

    Article  PubMed  CAS  Google Scholar 

  13. Radermacher P, Santak B, Becker H, Falke KJ (1989) Prostaglandin El and nitroglycerin reduce pulmonary capillary pressure but worsen VA/Q distributions in patients with ARDS. Anesthesiology 70:601–606

    Article  PubMed  CAS  Google Scholar 

  14. Prewitt RM, McCarthy J, Wood LDH (1981) Treatment of acute low pressure pulmonary edema in dogs. J Clin Invest 67:409–418

    Article  PubMed  CAS  Google Scholar 

  15. Gottlieb SS, Wood LDH, Hansen DE, Long R (1987) The effect of nitroprusside on pulmonary edema, oxygen exchange, and blood flow in hydrochloric acid aspiration. Anesthesiology 67:203–210

    Article  PubMed  CAS  Google Scholar 

  16. Gattinoni L, Pesenti A, Bombino M, et al. (1988) Relationships between lung compute tomographic density, gas exchange, and PEEP in acute respiratory failure. Anesthesiology 69:824–832

    Article  PubMed  CAS  Google Scholar 

  17. Radermacher P, Santak B, Wüst HJ, Tarnow J, Falke KJ (1990) Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory distress syndrome: effects on pulmonary capillary pressure and ventilation-perfusion distributions. Anesthesiology 72:238–244

    Article  PubMed  CAS  Google Scholar 

  18. Perlman MB, Lo SK, Malik AB (1986) Effect of prostacyclin on pulmonary vascular response to thrombin in awake sheep. J Appl Physiol 60:546–553

    PubMed  CAS  Google Scholar 

  19. Mélot C, Naeije R, Mols P, Hallemans R, Lejeune P, Jaspar N (1987) Pulmonary vascular tone improves pulmonary gas exchange in the adult respiratory distress syndrome. Am Rev Respir Dis 136:1232–1236

    Article  PubMed  Google Scholar 

  20. Radermacher P, Huet Y, Pluskwa F, et al. (1988) Comparison of ketanserin and sodium nitroprusside in patients with severe ARDS. Anesthesiology 68:152–157

    Article  PubMed  CAS  Google Scholar 

  21. Mélot C, Lejeune P, Leeman M, Moraine JJ, Naeije R (1989) Prostaglandin El in the adult respiratory distress syndrome. Am Rev Respir Dis 139:106–110

    Article  PubMed  Google Scholar 

  22. Lynch JP, Mhyre JG, Dantzker DR (1979) Influence of cardiac output on intrapulmonary shunt. J Appl Physiol 46:315–322

    PubMed  CAS  Google Scholar 

  23. Breen PH, Schumacker PT, Hedenstierna G, Ali J, Wagner PD, Wood LDH (1982) How does increased cardiac output increase shunt in pulmonary edema? J Appl Physiol 53:1273–1280

    Article  PubMed  CAS  Google Scholar 

  24. Domino KB, Wetstein L, Glassner SA, et al. (1983) Influence of mixed venous oxygen tension (PvO2ood flow to atelectatic lung. Anesthesiology 59:428–434

    Article  PubMed  CAS  Google Scholar 

  25. Naeije R, Mélot C, Mols P, Hallemans R (1982) Effects of vasodilators on hypoxic pulmonary vasoconstriction in normal man. Chest 82:404–410

    Article  PubMed  CAS  Google Scholar 

  26. Sprague RS, Stephenson AH, Lonigro AJ (1984) Prostaglandin 12 supports blood flow to hypoxic alveoli in anesthetized dogs. J Appl Physiol 56:1246–1251

    PubMed  CAS  Google Scholar 

  27. Bihari D, Smithies M, Gimson A, Tinker J (1987) The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 317:397–403

    Article  PubMed  CAS  Google Scholar 

  28. Schumacker PT, Cain SM (1987) The concept of critical oxygen delivery. Intensive Care Med 13:223–229

    Article  PubMed  CAS  Google Scholar 

  29. Kariman K, Burns SR (1985) Regulation of tissue oxygen extraction is disturbed in adult respiratory distress syndrome. Am Rev Respir Dis 132:109–114

    PubMed  CAS  Google Scholar 

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© 1991 Springer-Verlag Berlin, Heidelberg

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Radermacher, P., Santak, B. (1991). Vasodilating Therapy in ARDS. In: Vincent, J.L. (eds) Update 1991. Update in Intensive Care and Emergency Medicine, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84423-2_35

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  • DOI: https://doi.org/10.1007/978-3-642-84423-2_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53672-7

  • Online ISBN: 978-3-642-84423-2

  • eBook Packages: Springer Book Archive

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