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Update 1991 pp 269–273Cite as

Tumor Necrosis Factor and the Disbalance Between Coagulant and Anticoagulant Mechanisms in Septicemia

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 14))

Abstract

Septic shock is frequently complicated by massive activation of the coagulation system. This can occur concomitantly with biphasic changes in the fibrinolytic system, involving both activation and inhibition of plasminogen activation [1, 2]. The net result of the altered hemostatic state in septicemia is widespread microvascular thrombosis. The early events leading to these disturbances are incompletely understood, although changes in the functional properties of the vascular endothelium seem to be of pivotal importance.

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References

  1. Marder VJ, Martin SE, Francis CW, Colman RW (1987) Consumptive thrombohemorrhagic disorders. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (eds) Hemostasis and thrombosis: basic principles and clinical practice, 2nd edn. Lippincott, Philadelphia, pp 975–1015

    Google Scholar 

  2. Brandtzaeg P, Joo GB, Brusletto B, Kierulf P (1990) Plasminogen activator inhibitor 1 and 2, α-2-antiplasmin, plasminogen, and endotoxin levels in systemic meningococcal disease. Thromb Res 57:271–278

    Article  PubMed  CAS  Google Scholar 

  3. Bendtzen K (1988) Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity. Immunol Lett 19:183–192

    Article  PubMed  CAS  Google Scholar 

  4. Tracey KJ, Vlassara H, Cerami A (1989) Cachectin/tumour necrosis factor. Lancet I:1122–1125

    Article  Google Scholar 

  5. Hesse DG, Tracey KJ, Fong Y, et al. (1988) Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 166:147–153

    PubMed  CAS  Google Scholar 

  6. Michie HR, Manogue KR, Spriggs DR, et al. (1988) Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318:1481–1486

    Article  PubMed  CAS  Google Scholar 

  7. Van Deventer SJH, Büller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A (1991) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood (in press)

    Google Scholar 

  8. Waage A, Halstensen A, Espevik T (1987) Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet i : 355–357

    Article  Google Scholar 

  9. Girardin E, Grau GE, Dayer JM, et al. (1988) Tumor necrosis factor and interleukin 1 in the serum of children with severe infectious purpura. N Engl J Med 319:397–400

    Article  PubMed  CAS  Google Scholar 

  10. Tracey KJ, Fong Y, Hesse DG, et al. (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330:662–664

    Article  PubMed  CAS  Google Scholar 

  11. Fong Y, Tracey KJ, Moldawer LL, et al. (1989) Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 β and interleukin 6 appearance during lethal bacteremia. J Exp Med 170:1627–1633

    Article  PubMed  CAS  Google Scholar 

  12. Tracey KJ, Lowry SF, Fahey III TJ, et al. (1987) Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 164:415–422

    PubMed  CAS  Google Scholar 

  13. Nawroth PP, Stern DM (1986) Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 163:740–745

    Article  PubMed  CAS  Google Scholar 

  14. Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone MA Jr (1986) Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci USA 83:4533–4537

    Article  PubMed  CAS  Google Scholar 

  15. Conway EM, Rosenberg RD (1988) Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 8:5588–5592

    PubMed  CAS  Google Scholar 

  16. Conckling PR, Greenberg CS, Weinberg JB (1988) Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. Blood 72:128–133

    Google Scholar 

  17. Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone MA Jr, Loskutoff DJ (1988) Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 263:5797–5803

    PubMed  CAS  Google Scholar 

  18. Medina R, Socher SH, Han JH, Friedman PA (1989) Interleukin-1, endotoxin or tumor necrosis factor/cachectin enhance the level of plasminogen activator inhibitor messenger RNA in bovine aortic endothelial cells. Thromb Res 54:41–52

    Article  PubMed  CAS  Google Scholar 

  19. Van Hinsbergh VWM, Kooistra T, van den Berg EA, Princen HMG, Fiers W, Emeis JJ (1988) Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo. Blood 72:1467–1473

    PubMed  Google Scholar 

  20. Bevilacqua MP, Schleef RR, Gimbrone MA Jr, Loskutoff DJ (1986) Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1. J Clin Invest 78:587–591

    Article  PubMed  CAS  Google Scholar 

  21. Van Hinsbergh VWM, van den Berg EA, Fiers W, Dooijewaard G (1990) Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells. Blood 75:1991–1998

    PubMed  Google Scholar 

  22. Nawroth P, Hardley D, Matsueda G, et al. (1988) Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas. J Exp Med 168:637–647

    Article  PubMed  CAS  Google Scholar 

  23. Mathison JC, Wolfson E, Ulevitch RJ (1988) Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest 81:1925–1937

    Article  PubMed  CAS  Google Scholar 

  24. Bauer KA, ten Cate H, Barzegar S, Spriggs DR, Sherman ML, Rosenberg RD (1989) Tumor necrosis factor infusions have a procoagulant effect on the hemostatic mechanism of humans. Blood 74:165–172

    PubMed  CAS  Google Scholar 

  25. Van der Poll T, Büller HR, ten Cate H, et al. (1990) Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 322:1622–1627

    Article  PubMed  Google Scholar 

  26. Drake TA, Morrissey JH, Edgington TS (1989) Selective cellular expression of tissue factor in human tissues: implications for disorders of hemostasis and thrombosis. Am J Pathol 134:1087–1097

    PubMed  CAS  Google Scholar 

  27. Brett J, Gerlach H, Nawroth P, Steinberg S, Godman G, Stern D (1989) Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. J Exp Med 169:1977–1991

    Article  PubMed  CAS  Google Scholar 

  28. Van der Poll T, van Deventer SJH, Büller HR, Sturk A, ten Cate JW (1991) Comparison of the early dynamics of coagulation activation after injection of endotoxin and tumor necrosis factor in healthy humans. In: Levin J, Sturk A, ten Cate JW (eds) Bacterial endotoxins and mediators. Wiley & Sons, New York (in press)

    Google Scholar 

  29. Van der Poll T, Levi M, Büller HR, Hack CE, van Deventer SJH, ten Cate JW (1990) Effects of tumor necrosis factor on the fibrinolytic system in healthy volunteers. Blood 76 (Suppl 1):441 (abstract)

    Google Scholar 

  30. Suffredini AF, Harpel PC, Parrillo JE (1989) Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N Engl J Med 320:1165–1172

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. T. van der Poll
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  2. M. Levi
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  3. J. H. van Deventer
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Clinical Director) (Clinical Director)

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© 1991 Springer-Verlag Berlin, Heidelberg

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van der Poll, T., Levi, M., van Deventer, J.H. (1991). Tumor Necrosis Factor and the Disbalance Between Coagulant and Anticoagulant Mechanisms in Septicemia. In: Vincent, J.L. (eds) Update 1991. Update in Intensive Care and Emergency Medicine, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84423-2_31

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  • DOI: https://doi.org/10.1007/978-3-642-84423-2_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53672-7

  • Online ISBN: 978-3-642-84423-2

  • eBook Packages: Springer Book Archive

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