Abstract
During the past 40 years, essentially since the introduction of antibiotics, the incidence of gram-negative bacteremia has risen dramatically [1, 2], increasing from 7 episodes per 1000 hospital admissions in 1965 to 13 episodes per 1000 admissions in 1974 [3]. It is estimated that 70000 to 300000 cases occur annually [4, 5]. In a variety of studies [2, 3, 6–19], the crude mortality is reported to be in the range of 25% to 50%, while the attributable mortality is estimated to be 25% to 32% [4, 5, 14, 20]. Mortality rates increase in patients in whom gram-negative bacteremia leads to shock. This complication develops in approximately 40% of bacteremic patients and results in reported mortality rates of 40% to 77% [9, 18].
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Martin, M.A. (1991). The Respiratory Distress Syndrome in Adults with Gram-negative Sepsis. In: Vincent, J.L. (eds) Update 1991. Update in Intensive Care and Emergency Medicine, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84423-2_21
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DOI: https://doi.org/10.1007/978-3-642-84423-2_21
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