The Maternotrophoblastic Interface: Uteroplacental Blood Flow
Soon after implantation, primary trophoblast exerts its proteolytic properties; distended vascular lakes are thus opened, and maternal red blood cells appear within the lacunae at the previllous stage . Knoth and Larsen  were surprised to find only one example of such penetration in the ultrastructural study of their 11-day-old implanted ovum. Enders , quoting a Carnegie Institute publication by O’Rahilly and Muller, suggests that there is a true blood flow within lacunae of the human placental disk 10–11 days after ovulation, i.e., 4–5 days after implantation. There is now general agreement that the vessels which are tapped are venous capillaries or lakes. It is therefore obvious that only a limited quantity of blood will enter the lacunae through a retrograde effect. Kaufmann  has proposed that spiral arteries are tapped around days 28–29. It thus appears that some maternal blood is diverted to the lacunae, but most probably in minute quantities.
KeywordsSpiral Artery Extravillous Trophoblast Intervillous Space Uteroplacental Blood Flow Primary Trophoblast
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- 3.Kaufmann P (1981) Entwicklung der Plazenta. In: Becker V, Schiebler TH, Kublif (eds) Die Plazenta des Menschen. Thieme, Stuttgart, p 13Google Scholar
- 4.Ramsey E, Donner J (1980) Placental vasculature and circulation. Thieme, StuttgartGoogle Scholar
- 5.Boyd JD, Hamilton WJ (1970) The human placenta. Heffer, Cambridge, pp 61–91Google Scholar
- 8.Schaaps JP (1988) Dynamic imaging of the utero placental border in the first trimester of human pregnancy. Troph Res 3: 37–45Google Scholar
- 9.Schaaps JP (1989) Etude de la circulation utéro-trophoblastique au cours du premier trimestre de la grossesse. Thesis, University of LiegeGoogle Scholar
- 13.Hustin J, Schaaps JP, Lambotte R (1988) Anatomical studies of the utero placental vascularization in the first trimester of pregnancy. Troph Res 3: 49–60Google Scholar
- 15.Benirschke K, Kaufmann P (1990) Pathology of the human placenta, 2nd edn. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 17.Aplin JD (1989) Cellular biochemistry of the endometrium. In: Wynn RM, Jollie WP (eds) Biology of the uterus, 2nd edn. Plenum, New York, pp 89–119Google Scholar
- 18.Bell SC (1988) Secretory endometrial/decidual proteins and their function in early pregnancy. J Reprod Fertil [Suppl] 36: 109–125Google Scholar
- 22.Henry RJ, Cannon DC, Winkelman JN (1974) Clinical chemistry: principles and technics. Harper and Row, Hagerstown, pp 1114–1115Google Scholar
- 23.Kaplan La, Pesce AJ (1984) Clinical chemistry: theory, analysis and correlation. Mosby, St Louis, pp 623–624Google Scholar