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Abstract

Endoscopic visualization of the embryo (embryoscopy) is a new and evolving technology. The concept of direct visualization of the embryo reflects not only our ongoing quest for improved diagnostic techniques, but also the potential for direct, targeted embryonic therapy. Advancing technology has rendered the fetus and its environment accessible to the “outside” world and, therefore, to diagnosis and therapy. Among the latest of such technologies is embryoscopy, which utilizes high-resolution fiberoptic equipment for direct visualization of the embryo/fetus [1–6].

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References

  1. Reece EA, Hobbins JC (1991) Embryoscopy: an evolving technology for early prenatal diagnosis. In: Chapman M, Grudzinskas G, Chard T (eds) The embryo normal and abnormal development and growth. Springer, Berlin Heidelberg New York, pp 123–140

    Google Scholar 

  2. Cullen MT, Reece EA, Whetham J, Hobbins JC (1989) Embryoscopy: description and utility of a new technique. Am J Obstet Gynecol 162: 82–86

    Google Scholar 

  3. Cullen MT, Reece EA, Viscarello RR, Hobbins JC (1989) Transcervical endoscopie visualization of prenatally diagnosed anomalies prior to second trimester termination. Proceeding of the Annual Meeting of the Society for Gynecology Investigation, March 1989

    Google Scholar 

  4. Reece EA, Rothmensch S, Whethan J, Cullen M, Hobbins JC (1991) Embryoscopy: a closer look at first-trimester diagnosis and treatment. Am J Obstet Gynecol (submitted)

    Google Scholar 

  5. Westin B (1954) Hysteroscopy in early pregnancy. Lancet ii (267): 872

    Google Scholar 

  6. Galliant A, Lueken RP, Lindermann HJ (1978) New instruments and new methods. A preliminary report about transcervical embryoscopy. Endoscopy 10: 47

    Google Scholar 

  7. Donald I, MacVicar J, Brown TG (1958) Investigation of abdominal masses by pulsed ultrasound. Lancet ii (274): 1188–1194

    Google Scholar 

  8. Hon EH, Quilligan EJ (1967) The classification of fetal heart rate. Conn Med 31: 779

    PubMed  CAS  Google Scholar 

  9. Green JJ, Hobbins JC (1988) Abdominal ultrasound of the first trimester fetus. Am J Obstet Gynecol 159: 165

    PubMed  CAS  Google Scholar 

  10. Hon EH (1968) An atlas of fetal heart rate patterns. Harty, New Haven

    Google Scholar 

  11. Manning FA, Hill LM, Platt LD (1981) Qualitative amniotic fluid volume determination by ultrasound: antepartum detection of intrauterine growth retardation. Am J Obstet Gynecol 139: 254

    PubMed  CAS  Google Scholar 

  12. Patrick J, Campbell K, Carmichael L, Natale R, Richardson B (1982) Patterns of gross fetal body movements over 24 hour observation intervals during the last 10 weeks of pregnancy. Am J Obstet Gynecol 142: 363–371

    PubMed  CAS  Google Scholar 

  13. Manning FA, Lange FR, Morrison J, Harman CR (1983) Determination of fetal health: methods for antepartum and intrapartum fetal assessment. Curr Probl Obstet Gynecol 7: 1

    Google Scholar 

  14. Beard RW, Filshie GM, Knight CA, Roberts GM (1979) The significance of the changes in the continuous fetal heart rates in the first stage of labor. J Obstet Gynecol Br Commonw 78: 865

    Article  Google Scholar 

  15. Romero R, Pilu G, Jeanty P, Ghidini A, Hobbins JC (1988) Prenatal diagnosis of congenital anomalies. Appleton and Lange Norwalk

    Google Scholar 

  16. Golbus MS, McGonigle KF, Goldberg JD, Filly RA, Callen PW, Anderson RL (1989) Fatal tissue sampling. The San Francisco experience with 190 pregnancies. West J Med 150: 423–430

    PubMed  CAS  Google Scholar 

  17. Valenti C (1972) Endoamnioscopy and fetal biopsy. A new technique. Am J Obstet Gynecol 141: 561–564

    Google Scholar 

  18. Scrimgeour JB (1973) Other techniques for antenatal diagnosis. In: Emery AEH (ed) Antenatal diagnosis of genetic disease. New York: Churchill-Livingstone, New York, pp 40–57

    Google Scholar 

  19. Hobbins JC, Mahoney MJ (1974) In utero diagnosis of hemoglobinopathies. Technique for obtaining fetal blood. N Engl J Med 290: 1065–1067

    Google Scholar 

  20. Rodeck CH, Nicolaides KH (1986) Fetoscopy. Br Med Bull 42: 296–300

    CAS  Google Scholar 

  21. Mahoney MJ, Hobbins JC (1977) Prenatal diagnosis of chondroectoderman dysplasia ( Ellis-Van Creveld syndrome) with fetoscopy and ultrasound. N Engl J Med 297: 258

    Google Scholar 

  22. Elias S (1983) Fetoscopy in prenatal diagnosis. Clin Perinatol 10: 357–367

    PubMed  CAS  Google Scholar 

  23. Hobbins JC, Mahoney MJ (1974) Progress toward in utero diagnosis of hemoglobinopathies: technique for obtaining fetal blood. N Engl J Med 290: 10651067

    Google Scholar 

  24. Daffos F, Capella-Pavlovsky M, Forestier F (1985) Fetal blood sampling during pregnancy with use of a needle guided by ultrasound. A study of 606 consecutive cases. Am J Obstet Gynecol 153: 655–660

    PubMed  CAS  Google Scholar 

  25. Hobbins JC, Grannum P, Romero R, Reece EA (1985) Percutaneous umbilical blood sampling. Am J Obstet Gynecol 152: 1–6

    PubMed  CAS  Google Scholar 

  26. Sievers S, Hagenbusch M, Eckert M (1983) Management of pregnant women with thalassemia minor. Fortschr Med 101: 687–688

    PubMed  CAS  Google Scholar 

  27. Hogge WA, Schomberg SA, Golbus MS (1986) Chorionic villus sampling: experience of the first 1000 cases. Am J Obstet Gynecol 154: 2349

    Google Scholar 

  28. Martin AO, Simpson JL, Rosinsky B et al. (1986) Chorionic Villus sampling in continuing pregnancies. II. Cytogenetic Reliability. Am J Obstet Gynecol 154: 1353

    Google Scholar 

  29. Hobbins JC, Grannum PAT, Berkowitz RL et al. (1979) Ultrasound in the diagnosis of congenital anomalies. Am J Obstet Gynecol 134: 331

    PubMed  CAS  Google Scholar 

  30. Bulic M, Podobnik M et al. (1987) First trimester diagnosis of low obstructive uropathy. An indication of initial renal function of the fetus. J Clin Ultrasound 6: 715

    Google Scholar 

  31. Vergani P, Ghidini A et al. (1987) Antenatal diagnosis of fetal acrania. J Ultrasound Med 6: 715

    PubMed  CAS  Google Scholar 

  32. Hill LM, Thomas ML et al. (1988) Sonographic assessment of the first trimester fetus. A cautionary note. Am J Perinatol 7: 97

    Google Scholar 

  33. Cutis JA, Watson L (1988) Sonographic diagnosis of omphalocele in the first trimester of fetal gestation. J Ultrasound Med 7: 97

    Google Scholar 

  34. Timor-Tritsch IE, Warner WB, Peisner DB, Pirsone E (1989) First trimester midgut herniation. A high frequency transvaginal sonographic study. Am J Obstet Gynecol 161: 831–833

    Google Scholar 

  35. Dumez Y (1990) Embryoscopy and congenital malformations. Proceedings of International Conference on Chorionic Villus Sampling and Early Prenatal Diagnosis, 28–29 May 1990, Athens

    Google Scholar 

  36. Roume J, Aubry MC, Labbe F, Dumez Y, Aubry JP, Henrion R (1985) Prenatal diagnosis of limb and digital abnormalities. Evaluation of the activity of the Port Royal University Clinic from 1979 to 1983. J Genet Hum 33: 457–461

    PubMed  CAS  Google Scholar 

  37. Dumez Y (1988) Embryoscopy and congenital malformations. Proceedings of the International Conference on Chorionic Villous Sampling and Early Prenatal Diagnosis, 28–29 May 1988, Athens

    Google Scholar 

  38. Moore KL (1988) The developing human. Clinically oriented embryology, 4th edn. Saunders, Philadelphia

    Google Scholar 

  39. Arey LB (1974) Development anatomy, 7th rev edn Saunders, Philadelphia

    Google Scholar 

  40. Hamilton WJ, Boyd JD, Mossman HW (1964) Human embryology, 3rd edn. Heffner, Cambridge

    Google Scholar 

  41. Pinter E, Reece EA, Leranth CZ, Sanyal MK, Hobbins JC, Mahoney MJ, Naftolin F (1986) Yolk sac failure in embryopathy due to hyperglycemia. An ultrastructural analysis of the yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions. Teratology 33: 363–374

    Google Scholar 

  42. Reece EA, Pinter E, Leranth CZ, Sanyal MK, Hobbins JC, Mahoney MJ, Naftolin F (1985) Ultrastructural analysis of malformations of the embryonic neural axis induced by hyperglycemic conceptus culture. Teratology 32: 363–374

    Article  PubMed  CAS  Google Scholar 

  43. Reece EA, Pinter E, Leranth CZ, Garcia-Segura LM, Sanyal MK, Hobbins JC, Mahoney MJ, Naftolin F (1989) Yolk sac failure in embryopathy due to hyperglycemia: horseradish peroxidase uptake in the assessment of yolk sac dysfunction. Ostet Gynecol 74: 755–762

    CAS  Google Scholar 

  44. Reece EA, Hobbins JC (1986) Diabetic embryopathy: pathogenesis, prenatal diagnosis and prevention. Obstet Gynecol Sury 41: 325–335

    Article  CAS  Google Scholar 

  45. Reece EA, Scioscia AL, Pinter E, Hobbins JC, Green JJ, Leranth CZ, Mahoney MJ, Naftolin F (1988) Prognostic significance of the human yolk sac assessed by ultrasonography. Am J Obstet Gynecol 159: 1191–1194

    PubMed  CAS  Google Scholar 

  46. Anderson WF (1984) Prospects for human gene therapy. Science 226: 401

    Article  PubMed  CAS  Google Scholar 

  47. Reece EA, Pinter E, Leranth CZ, Sanyal MK, Hobbins JC, Mahoney MJ, Naftolin F (1985) Ultrastructural analysis of malformations of the embryonic neural axis induced by hyperglycemic conceptus culture. Teratology 32: 363–374

    Article  PubMed  CAS  Google Scholar 

  48. Anderson WF (1985) Human gene therapy: scientific and ethical considerations. J Med Philos 10: 275

    PubMed  CAS  Google Scholar 

  49. Kantoff PW, Gillis AP, McLachlin OR et al. (1987) Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. J Exp Med 166: 219–234

    Article  PubMed  CAS  Google Scholar 

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© 1992 Springer-Verlag Berlin Heidelberg

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Reece, E.A. (1992). Embryoscopy. In: Barnea, E.R., Hustin, J., Jauniaux, E. (eds) The First Twelve Weeks of Gestation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84385-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-84385-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84387-7

  • Online ISBN: 978-3-642-84385-3

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