Zusammenfassung
Toxische Nierenschädigung, im Extremfall toxisches Nierenversagen, kann einerseits durch direkte chemische Wechselwirkung, wie bei Schwermetallen, durch Überempfindlichkeitsreaktionen, wie bei Methicillin, oder durch Entzündungsreaktionen im Bereich der Nierengefäße, wie bei Heroin, ausgelöst werden. Schädigungen der Nierenpapille verursachen der Abusus von bestimmten Analgetika oder deren kombinierte Verabreichung. Die kombinierte Anwendung von Pharmaka stellt überhaupt eine potentielle Ursache für toxische Nierenläsionen dar: z. B. werden die nephrotoxischen Effekte von Cephalosporinen bei gleichzeitiger Verabreichung mit Furosemid drastisch verstärkt [1].
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Pfaller, W., Gstraunthaler, G., Kotanko, P. (1991). Nephrotoxizität: Morphologie — Funktionsbeziehung. In: Guder, W.G., Lang, H. (eds) Pathobiochemie und Funktionsdiagnostik der Niere. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84384-6_6
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