Zusammenfassung
Die Nieren bilden den Primärharn durch passive Filtration in den Glomerula. Lange Zeit wurde angenommen, daß ausschließlich die Weite von Poren oder Porenäquivalenten der Glomerulummembran die Molekülgröße der Substanzen bestimmt, die noch filtriert werden können. Diese Annahme der einfachen mechanischen Filterfunktion der Niere führte zu der Vorstellung, daß sie durch Dialysemembranen weitgehend ersetzt werden kann.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Farquhar GM, Courtoy PJ, Lemkin MC, Kanwar YS (1982) Current knowledge of the functional architecture of the glomerular basement membrane in “New Trends in Basement Membrane Research” (Kühn K, Schöne HH, Timpl R eds) Raven Press, New York pp 9–29
Martinez-Hernandez A, Amenta PS (1983) The basement membrane in pathology. Lab Invest 48, 656–677
Timpl R (1989) Structure and biological activity of basement membrane proteins. Eur J Biochem 180, 487–503
Brenner BM, Hostetter TH, Hunes HD (1987) Molecular basis of proteinuria of glomerular origin. N Engl J Med 298, 826–833
Kanwar YS, Farquhar MG (1979) Presence of heparan sulfate in the glomerular basement membrane. Proc Natl Acad Sci USA, 76, 1303–1307
Olgemöller B, Schleicher E, Nerlich A, Wagner EM, Gerbitz KD (1989) Isolation, characterization and immunological determination of basement membrane associated heparan sulfate proteoglycan. Biol Chem Hoppe Seyler 370, 1321–1327
Schleicher E, Wagner EM, Olgemöller B, Nerlich A, Gerbitz KD (1989) Characterization and localization of basement membrane associated heparan sulfate proteoglycan in human tissues. Lab Invest 61, 323–332
Mynderse LA, Hassel JR, Kleinman HK, Martin GR, Martinez-Hemandez A (1983) Loss of heparan sulfate proteoglycan from glomerular basement membrane of nephrotic rats. Lab Invest 48, 292–302
Barsky SH, Rao NC, Restrepo C, Liotta LA (1984) Immunocytochemical enhancement of basement membrane antigens by pepsin: application in diagnostic pathology. Am J Clin Path 82, 191–194
Scheinman JI, Foidart J, Michael AF (1980) The immunohistology of glomerular antigens. V. The collagenous antigens of the glomerulus. Lab Invest 43, 373–381
Timpl R, Wick G, Gay S (1977) Antibodies to distinct types of collagens and procollagens and their application in immunohistology. J Immunol Meth 18, 165–175
Remberger K, Gay S, Adelmann BC (1976) Immunhistochemische Charakterisierung and Lokalisation unterschiedlicher Kollagentypen bei chronischen Nierenerkrankungen. Verh Dtsch Ges Path 60, 314–318
Rumpelt HJ, Langer KH, Schorer K, Straub E, Thanes W (1979) Split and extremely thin glomerular basement membranes in hereditary nephropathy (Alport’s syndrome) Virchows Arch (Pathol Anat) 263, 225–233
Kleppel MM, Kashtan CE, Budkowski RJ, Fish AJ, Michael AF (1987) Alport Familial Nephritis. J Clin Invest 80, 263–266
Nerlich A, Schleicher E (unveröffentlicht)
Schleicher E, Nerlich A, Gerbitz KD (1988) Pathobiochemical aspects of diabetic nephropathy. Klin Wschr 66, 873–882
Beisswenger PI, Spiro RG (1970) Human glomerular basement membrane: Chemical alteration in diabetes mellitus Science 168, 596–598
Mauer SM, Steffes MW, Brown DM (1981) The kidney in diabetes. Am J Med 70, 603–612
Falk RJ, Scheinman JI, Mauer MS, Michael AF (1983) Polyantigenic expansion of basement membrane constituents in diabetic nephropathy. Diabetes 32 (Suppl. 2), 34–39
Bendayan M (1985) Alteration in the distribution of type IV collagen in glomerular basal laminae in diabetic rats as revealed by immunocytochemistry and morphometric approach. Diabetologia 28, 373–378
Budkowski RJ, Langeveld JPM, Wieslander J, Hamilton J, Hudson BG (1987) Localization of the Goodpasture Epitope to a Novel Chain of Basement Membrane Collagen. J Biol Chem 262, 7874–7877
Rohrbach DH, Hassell JR, Kleinman HK, Martin GR (1982) Alterations in basement membrane (heparan sulfate) proteoglycan in diabetic mice. Diabetes 31, 185–188
Kanwar YS, Rosenzweig LJ, Linker A, Jakubowski ML (1983) Decreased de novo synthesis of glomerular proteoglycans in diabetes: Biochemical and autoradiographic evidence. Proc Natl Acad Sci USA 80, 2272–2275
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schleicher, E., Nerlich, A., Gerbitz, KD. (1991). Struktur, Funktion und Pathobiochemie der glomerulären Basalmembran. In: Guder, W.G., Lang, H. (eds) Pathobiochemie und Funktionsdiagnostik der Niere. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84384-6_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-84384-6_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53525-6
Online ISBN: 978-3-642-84384-6
eBook Packages: Springer Book Archive