Modulation of Endothelial Cell Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function, and Induction of a Novel Procoagulant Activity

  • S. Ogawa
  • C. Esposito
  • M. Matsumoto
  • J. Brett
  • D. Stern
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1990 / 1990/3)


Regulation of vascular permeability and the coagulation mechanism are two central properties of the endothelium (Gimbrone 1986). The presence of multiple active mechanisms through which endothelial cells contribute to the maintenance of barrier function and fluidity of blood has been demonstrated, suggesting that endothelial regulation of vascular homeostasis occurs in response to environmental stimuli.


Tissue Factor Procoagulant Activity Bovine Aortic Endothelial Cell Endothelial Monolayer Endothelial Cell Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. Ogawa
    • 1
  • C. Esposito
    • 1
  • M. Matsumoto
    • 1
    • 2
  • J. Brett
    • 1
  • D. Stern
    • 1
  1. 1.Department of Physiology and Cellular BiophysicsColumbia UniversityNew YorkUSA
  2. 2.First department of medicineOsaka University Medical School HospitalJapan

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