Development of Synthetic Proteinase Inhibitors as Anticoagulant Agents
Extracellular trypsin-like serine proteinases are involved in the processes of coagulation, fibrinolysis, kinin liberation and complement activation. These proteolytic enzymes are characterized by a reactive serine residue in the catalytic mechanism and attack peptide bonds following an arginine or lysine residue. Fig. 1 gives a schematic representation of the interlinked reactions of the enzymes participating in the plasma effector systems.
KeywordsBoxylic Acid Anticoagulant Agent Synthetic Inhibitor Guanidino Compound Clotting Enzyme
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