Development of Synthetic Proteinase Inhibitors as Anticoagulant Agents

  • F. Markwardt
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1990 / 1990/3)

Abstract

Extracellular trypsin-like serine proteinases are involved in the processes of coagulation, fibrinolysis, kinin liberation and complement activation. These proteolytic enzymes are characterized by a reactive serine residue in the catalytic mechanism and attack peptide bonds following an arginine or lysine residue. Fig. 1 gives a schematic representation of the interlinked reactions of the enzymes participating in the plasma effector systems.

Keywords

Amide Lysine Fibrinogen Prothrombin Toxicology 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. Markwardt
    • 1
  1. 1.Institute of Pharmacology and ToxicologyMedical Academy ErfurtErfurtGDR

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