Abstract
In postoperative care (Kakkar 1982, Bergqvist 1986, Turpie 1986) and in medical patients (Dahan 1986, Harenberg 1987a, Harenberg 1990) various low molecular weight (LMW) heparins have been shown to prevent thromboembolism with a single dose daily, while treatment for thromboembolism appears to require repeated daily subcutaneous injections (Holm 1986, Janvier 1987).
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References
Augustin J, Greten H (1979) The role of lipoprotein lipase, molecular properties and clinical relevance. In: Paoletti R, Gotto AM (Eds). Atherosclerosis Reviews. Vol. 5, pp. 91–124. Raven Press, New York
Basu D, Gallus A, Hirsh J, Cade J (1972) A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. New Engl J Med 287: 324–327
Bergqvist D, Burmark US, Frisell J, Hallböök T, Lindblad B, Risberg B, Törngren S, Wallin G (1986) Low molecular weight heparin once daily compared with conventional low-dose heparin twice daily. A prospective double-blind multicentre trial on prevention of postoperative thrombosis. Br J Surg 73: 204–208
Dahan R, Houlbert D, Caulin C, Cuzin E, Viltart C, Woler M, Segrestaa JM (1986) Prevention of deep vein thrombosis in elderly medical in-patients by a low molecular weight heparin: A randomized double-blind trial. Haemostasis 16: 159–164
Gray E, Begtsson-Olivecrona G, Olivecrona T, Barrowcliffe TW (1986) The anti-Xa activity of human hepatic triglyceride lipase ( HTGL ). J Lab Clin Med 109: 653–659
Harenberg J (1987) Modified anti-factor Xa chromogenic substrate assay for heparin and low molecular weight heparin. Ärztl Lab 33: 39–41
Harenberg J, Augustin J (1986, a) Lipolytic activities of low molecular weight heparins. Thromb Res 42:865–866
Harenberg J, Augustin J (1987, b) Antithrombotic action of hepatic triglyceride lipase - fact or fiction. Thrombos Haemostas 57:241
Harenberg J, de Vries JX (1983) Characterization of heparins by high performance size exclusion liquid chromatography. J Chromatogr 261: 287
Harenberg J, Giese Ch, Dempfle CE, Stehle G, Heene DL (1988a) Monitoring of heparin and low molecular weight heparin with capillary and venous whole blood. Thrombos Haemostas 60: 377–381
Harenberg J, Giese Ch, Dempfle CE, Stehle G, Heene DL (1989, c) Biological activity and safety of the subcutaneous administration of high doses of low molecular weight heparin for 8 days in human volunteers. Thrombos Haemostas 61:357–362
Harenberg J, Giese Ch, Knödler A, Zimmermann R (1986, b) Anti-factor Xa clotting method for heparin and low molecular weight heparins. Ärztl Lab 32:181–184
Harenberg J, Giese Ch, Knödler A, Zimmermann R (1989, a) Comparative study on a new one-stage clotting assay for heparin and its low molecular weight derivatives. Haemostasis 19:13–20
Harenberg J, Gnasso A, de Vries JX, Zimmermann R, Augustin J (1985) Anticoagulant and lipolytic effects of a low molecular weight heparin fraction. Thromb Res 39: 683–692
Harenberg J, Heene DL (1988, b) Pharmacology and special clinical applications of lowmolecular-weight heparins. Am J Hematol 29:233–240
Harenberg J, Kallenbach B, Martin U, Dempfle CE, Zimmermann R, Kübler W, Heene DL (1990) Randomized controlled study of heparin and low molecular weight heparin for prevention of deep-vein thrombosis in medical patients. Thromb Res (in press)
Harenberg J, Leber G, Augustin J, Raedsch R, Schwarz F, Stiehl A, Zimmermann R (1987, a) Long term prophylaxis of thromboembolism with low molecular weight heparin. K1in Wschr 65:331–337
Harenberg J, Leber G, Dempfle CE, Heene DL, Zimmermann R, Kübler W (1989, b) Long term anticoagulation with low molecular weight heparin in outpatients with side effects on oral anticoagulants. Nouv Rev Fr Hematol 31:363–369
Harenberg J, Stehle G, Dempfle CE, von Hodenberg E, Heene DL (1989, d) Influence of the low molecular weight Heparin CY 216. on lipases and blood coagulation. Ärzt Lab 35:73–79
Holm HA, Abildgaard U (1982) Heparin treatment of deep venous thrombosis: correlation between clinical effects and heparin assays. In: Witt J (ed), Heparin–New Biochemical and Medical Aspects. Walter de Gruyter & Co., Berlin, New York, pp 289–300
Holm HA, Ly B, Handeland GF, Abildgaard U, Arnesen KE, Gottschalk P, Hoeg V, Aandahl M, Haugen K, Laerum F, Scheel B, Sortland O, Vinje B (1986) Subcutaneous heparin treatment of deep venous thrombosis: A comparison of unfractionated and low molecular weight heparin. Haemostasis 16: 30–37
Janvier G, Winnock S, Dugrais G, Vallet A, Dardel E, Serise JM, Calen S, Vergnes C, Toulemonde F (1987) Treatment of deep venous thrombosis with a very low molecular weight heparin fragment (CY 222). Haemostasis 7: 49–58
Kakkar VV, Djazaeri B, Fok J, Fletcher M, Scully MF, Westwick J (1982) Low-molecular weight heparin and prevention of postoperative deep vein thrombosis. Brit Med J 284: 375–379
Owren PA (1959) Thrombotest — a new method for controlling anticoagulant therapy. Lancet II:754–756
Teien AN, Abildgaard U, Höök M, Lindahl U (1977) Anticoagulation activity of heparin: assay of bovine, human and porcine preparations by amidolytic and clotting methods. Thromb Res 11: 107–117
Teien AN, Lie M (1975) Heparin assay in plasma: A comparison of five clotting methods. Thromb Res 7: 777–788
Turpie AGG, Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M Hull, RD, Gent M (1986) A randomized controlled trial of a low-molecular weight heparin ( Enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. New Engl J Med 315: 925–929
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© 1990 Springer-Verlag Berlin Heidelberg
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Harenberg, J. (1990). Clinical Pharmacologal Profile of Low Molecular Weight Heparins. In: Harenberg, J., Heene, D.L., Stehle, G., Schettler, G. (eds) New Trends in Haemostasis. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1990 / 1990/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84318-1_14
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DOI: https://doi.org/10.1007/978-3-642-84318-1_14
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