Skip to main content
SpringerLink
Log in
Book cover

New Trends in Haemostasis pp 107–122Cite as

Anti-Platelet Treatment of Metastasis

  • Conference paper

  • 65 Accesses

Abstract

Metastasis is a multistep process involving detachment of tumour cells from the primary site, dissemination through the blood stream, arrest in capillary beds, adherence to the vascular wall, dissolution of the basal lamina, migration and growth in extravascular spaces (see Poste and Fidler 1980, Terranova et al 1986, for reviews). The involvement of platelets in the metastatic process has been suggested on the basis of clinical and experimental data (see Gasic 1984, Mehta 1984, Jamieson et al 1987, Weiss et al 1989 for reviews). In the present paper, we will discuss the possible in vitro and in vivo interactions between platelets, tumour cells, endothelial cells and sub-endothelial matrix, the relevance of these multiple interactions for the pathogenesis of metastases and their possible pharmacological modulation for a selective anti-metastatic therapy.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abecassis J, Millon-Collard R, Klein-Soyer C, Nicora F, Fricker J-P, Beretz A, Eber M, Muller D, Cazenave J-P (1987) Adhesion of human breast cancer cell line MCF-7 to human vascular endothelial cells in culture. Enhancement by activated platelets. Int J Cancer 40: 525–531.

    Google Scholar 

  • Akiyama SK, Nagata K, Yamada KM (1990) Cell surface receptors for extracellular matrix components. Biochim Biophys Acta 1031: 91–110

    PubMed  CAS  Google Scholar 

  • Bastida E, Ordinas A, Giardina SL, Jamieson GA (1982)

    Google Scholar 

  • Differentiation of platelet-aggregating effects of human tumor cell lines based on inhibition studies with apyrase, hirudin, and phospholipase. Cancer Res 42:4348–4352

    Google Scholar 

  • Bastida E, Almirall L, Buchanan MR, Haas TA, Lauri D, Orr WB (1987) Effects of 13-HODE and HETE’s in tumour cell/endothelial cell interactions. Thromb Haemost 58: 315

    Google Scholar 

  • Bastida E, Ordinas A (1988) Platelet contribution to the formation of metastatic foci: the role of cancer cell-induced platelet activation. Haemostasis 18: 29–36

    PubMed  CAS  Google Scholar 

  • Bastida E, Almirall L, Bertomeu MC, Ordinas A (1989) Influence of shear stress on tumor-cell adhesion to endothelial-cell extracellular matrix and its modulation by fibronectin. Int J Cancer 43: 1174–1178

    Article  PubMed  CAS  Google Scholar 

  • Boukerche H, Berthier-Vergnes 0, Tabone E, Doré J-F, Leung LLK, McGregor JL (1989a) Platelet-melanoma cell interaction is mediated by the glycoprotein IIb-IIIa complex. Blood 74: 658–663

    PubMed  CAS  Google Scholar 

  • Boukerche H, Berthier-Vergnes O, Bailly M, Doré J-F, Leung LLK, McGregor JL (1989b) A monoclonal antibody (LYP18) directed against the blood platelet glycoprotein IIb/IIIa complex inhibits human melanoma growth in vivo. Blood 74: 909–912

    PubMed  CAS  Google Scholar 

  • Bretti S, Neri P, Lozzi L, Rustici M, Comoglio P, Giancotti F, Tarone G (1989) Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site. Int J Cancer 43: 102–106

    Article  PubMed  CAS  Google Scholar 

  • Buchanan MR, Bastida E (1987) The role of 13-HODE and HETEs in vessel wall/circulating blood cell interaction. Agents and Actions 22: 337–339

    Article  Google Scholar 

  • Charon MH, Poggi A, Donati MB, Marguerie G (1990) Synthetic peptide with antithrombotic activity. In: Rivier JE and Marshall GR (eds) Peptides. Chemistry, structure and biology. ESCOM, Leiden pp 82–83

    Google Scholar 

  • Chmielewska J, Poggi A, Mussoni L, Donati MB, Garattini S (1980) Blood coagulation changes in JW Sarcoma, a new metastasizing tumour in mice. Europ J Cancer 16: 1399–1407

    Article  CAS  Google Scholar 

  • Chopra H, Hatfield JS, Chang YS, Grossi I, Fitgerald LA, O’Gara CY, Marnett LJ, Diglio CA, Taylor JD, Honn KV (1988) Role of tumor cell cytoskeleton and membrane glycoprotein IRGpIIb/IIIa in platelet adhesion to tumor cell membrane and tumor cell-induced platelet aggregation. Cancer Res 48: 3787–3800

    PubMed  CAS  Google Scholar 

  • Costantini V, Fuschiotti P, Allegrucci M, Agnelli G, Nenci GC, Fioretti MC (1988) Platelet-tumor cell interaction: effect of prostacyclin and a synthetic analog on metastasis formation. Cancer Chemother Pharmacol 22: 289–293

    Article  PubMed  CAS  Google Scholar 

  • Crissman JD, Hatfield JS, Menter DG, Sloane B, Honn KV (1988) Morphological study of the interaction of intravascular tumor cells with endothelial cell and subendothelial matrix. Cancer Res 48: 4065–4072

    PubMed  CAS  Google Scholar 

  • Delaini F, Giavazzi R, De Bellis Vitti G, Alessandri G, Mantovani A, Donati MB (1981) Tumor sublines with different metastatic capacity induce similar blood coagulation changes in the host. Br J Cancer 43: 100–104

    Article  PubMed  CAS  Google Scholar 

  • Deuel TF, Senior RM, Huang JS, Griffin GL (1982) Chemotaxis of monocytes and neutrofils to platelet derived growth factor. J Clin Invest 69: 1046–1049

    Article  PubMed  CAS  Google Scholar 

  • Donati MB, Poggi A (1980) Malignancy and haemostasis. Br J Heamatol 44: 173–182

    Article  CAS  Google Scholar 

  • Donati MB, Rotilio D, Delaini F, Giavazzi R, Mantovani A, Poggi A (1982) Animal models for the study of platelet-tumor cell interactions. In: Interaction of platelets and tumor cells. Jamieson GA (ed) A.R.Liss Publisher, New York, NY, pp 159–174

    Google Scholar 

  • Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. New Engl J Med 315: 1650–1659

    Article  PubMed  CAS  Google Scholar 

  • Estrada J, Nicolson G (1984) Tumor-cell-platelet aggregation does not correlate with metastatic potential of rat 13762NF mammary adenocarcinoma tumor cell clones. Int J Cancer 34: 101–105

    Article  PubMed  CAS  Google Scholar 

  • Frazier WA (1987) Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells. J Cell Biol 105: 625–632

    Article  PubMed  CAS  Google Scholar 

  • Gasic G, Gasic T (1962) Removal of sialic acid from the cell coat in tumor cells and vascular endothelium and its effects on metastasis. Proc Natl Acad Sci USA 48: 1172–1177

    Article  PubMed  CAS  Google Scholar 

  • Gasic GJ, Gasic TB, Stewart CC (1968) Antimetastatic effects associated with platelet reduction. Proc Natl Acad Sci USA 61:45–52 Gasic GJ, Gasic TB, Murphy S (1972) Anti-metastatic effect of aspirin. Lancet 2: 713

    Google Scholar 

  • Gasic GJ, Gasic TB, Galanti N, Johnson T, Murphy S (1973) Platelettumor-cell interactions in mice: the role of platelets in spread of malignant disease. Int J Cancer 11: 704–718

    Article  PubMed  CAS  Google Scholar 

  • Gasic GJ (1984) Role of plasma, platelets, and endothelial cells in tumor metastasis. Cancer Metastasis Rev 3: 99–116

    Article  PubMed  CAS  Google Scholar 

  • Gastpar H (1972) The inhibition of the cancer cell stickiness by pyrimido-pyrimidine derivatives induced by inhibition of platelet aggregation. Acta Med Scand Suppl 525: 269–271

    Google Scholar 

  • Giavazzi R, Alessandri G, Spreafico F, Garattini S, Mantovani A (1980) Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours. Br J Cancer 42:462–472 Goustin AS, Leof EB, Shipley GD, Moses HL (1986) Growth factors and cancer. Cancer Res 46: 1015–1029

    Google Scholar 

  • Grignani G, Pacchiarini L, Almasio P, Pagliarino M, Gamba G, Rizzo SC, Ascari E (1983) Characterization of the platelet-aggregating activity of cancer cells with different metastatic potential. Int J Cancer 38: 237–244

    Article  Google Scholar 

  • Grossi IM, Fitzgerald LA, Umbarger LA, Nelson KK, Diglio CA, Taylor D, Honn KV (1989) Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49: 1029–1037

    PubMed  CAS  Google Scholar 

  • Heino J, Massagué J (1989) Transforming growth factor-beta switches the pattern of intergrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. J Biol Chem 264: 21806–21811

    PubMed  CAS  Google Scholar 

  • Heldin C-H and Westermark B (1984) Growth factors: mechanism of action and relation to oncogenes. Cell 37: 9–20

    Article  PubMed  CAS  Google Scholar 

  • Heldin C-H and Westermark B (1989) Growth factors as transforming proteins. Eur J Biochem 184: 487–496

    Article  PubMed  CAS  Google Scholar 

  • Hilgard P, Heller H, Schmidt CG (1976) The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL). Z Krebsforsch Klin Onkol 86: 243–250

    Article  CAS  Google Scholar 

  • Honn KV, Cicone B, Skoff A (1981) Prostacyclin: a potent antimetastatic agent. Science 212: 1270–1272

    Article  PubMed  CAS  Google Scholar 

  • Honn KV (1983) Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin thromboxane A2 system. Clin Expl Metastasis 1: 103–114

    Article  CAS  Google Scholar 

  • Honn KV, Onoda JM, Diglio CA, Sloane BF (1983) Calcium channel blockers:potential antimetastatic agents. Proc Soc Exp Biol Med 174: 16–19

    PubMed  CAS  Google Scholar 

  • Honn KV, Onoda JM, Diglio CA, Carufel MM, Taylor JD, Sloane BF (1984) Inhibition of tumor cell-platelet interactions and tumor metastasis by the calcium channel blocker nimodipine. Clin Expl Metastasis 2: 61–72

    Article  CAS  Google Scholar 

  • Honn KV, Onoda JM, Pamapalona K, Battaglia M, Neagos G, Taylor JD, Diglio CA, Sloane BF (1985) Inhibition by dihydropyridine class calcium channel blockers of tumor cell-platelet-endothelial cell interactions in vitro and metastasis in vivo. Biochem Pharmacol 34: 235–241

    Article  PubMed  CAS  Google Scholar 

  • Huang TF, Holt JC, Lukasiewicz, Niewiarowski S (1987) Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. J Biol Chem 262: 16157–16163

    Google Scholar 

  • Humphries MJ, Olden K, Yamada KM (1986) A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233: 467–470

    Article  PubMed  CAS  Google Scholar 

  • Humphries MJ, Yamada KM, Olden K (1988) Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16–F10 murine melanoma cells. J Clin Invest 81: 782–790

    Article  PubMed  CAS  Google Scholar 

  • Hynes RO (1987) Integrins: a family of cell surface receptors. Cell 48: 549–554

    Article  PubMed  CAS  Google Scholar 

  • Jamieson GA, Bastida E, Ordinas A (1987) Interaction of platelets and tumour cells. In: Maclntyre and Gordon J (eds) Platelets in Biology and Pathology III. Elsevier Science Publisher, Amsterdam, pp 161–189

    Google Scholar 

  • Karpatkin S, Ambrogio C, Pearlstein E (1984) Lack of effect of in vivo prostacyclin on the development of pulmonary metastases in mice following intravenous injection of CT26 colon carcinoma, Lewis lung carcinoma, or B16 amelanotic melanoma cells. Cancer Res 44: 3880–3883

    PubMed  CAS  Google Scholar 

  • Karpatkin S, Pearlstein E, Ambrogio C, Coller BS (1988) Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo. J Clin Invest 81: 1012–1019

    Article  PubMed  CAS  Google Scholar 

  • Katz IR, Thorbecke GJ, Bell MK, Yin J-Z, Clarke D, Zucker MB (1986) Protease-induced immunoregulatory activity of platelet factor 4. Proc Natl Acad Sci USA 83: 3941–3945

    Article  Google Scholar 

  • Kimura AK, Mehta P, Xiang J, Lawson D, Dugger D, Kao K-J, Ambrose LL (1987) The lack of correlation between experimental metastatic potential and platelet aggregating activity of B16 melanoma clones viewed in relation to tumor cell heterogeneity. Clin Expl Metastasis 5: 125–133

    Article  CAS  Google Scholar 

  • Knudsen KA, Smith L, Smith S, Karczewski J, Tuszynski GP (1988a) Role of IIb-IIIa-like glycoproteins in cell-substratum adhesion of human melanoma cells. J Cell Physiol 136: 471–478

    Article  PubMed  CAS  Google Scholar 

  • Knudsen KA, Tuszynski GP, Huang T-F, Niewiarowski S (1988b) Trigramin, an RGD-containing peptide from snake venom, inhibits cell-substratum adhesion of human melanoma cells. Exp Cell Res 179: 42–49

    Article  PubMed  CAS  Google Scholar 

  • Lampugnani MG, Crawford N (1987) Tumor cell induced platelet aggregation: studies with cloned metastatic and non metastatic variants. Invasion Metastasis 7: 311–324

    PubMed  CAS  Google Scholar 

  • Lauri D, Bertomeu MC, Orr FW, Bastida E, Sander D, Buchanan MR (1990) Interleukin-1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: in vitro and in vivo studies. Clin Exp Metastasis 8: 27–32

    Article  PubMed  CAS  Google Scholar 

  • Lerner WA, Pearlstein E, Ambrogio C, Karpatkin S (1983) A new mechanism for tumor-induced platelet aggregation. Comparison with mechanisms shared by other tumors with possible pharmacologic strategy toward prevention of metastases. Int J Cancer 31: 463–469

    Google Scholar 

  • Lichtner RB, Hutchinson G, Wedderbrun N, Hellmann K (1985) Antiplatelet pyrimido-pyrimidines and metastasis. Cancer Treat Rev 12: 221–234

    Article  PubMed  CAS  Google Scholar 

  • Lyons RM, Moses HL (1990) Transforming growth factors and the regulation of cell proliferation. Eur J Biochem 187: 467–473

    Article  PubMed  CAS  Google Scholar 

  • Marguerie GA, Edgington TS, Plow EF (1980) Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. J Biol Chem 255: 154–161

    PubMed  CAS  Google Scholar 

  • Mehta P (1984) Potential role of platelets in the pathogenesis of tumor metastasis. Blood 63: 55–63

    PubMed  CAS  Google Scholar 

  • Menter DG, Steinert BW, Sloane B, Gundlach N, O’Gara CY, Marnett LJ, Diglio C, Walz D, Taylor JD, Honn KV (1987) Role of platelet membrane in enhancement of tumor cell adhesion to endothelial cell extracellular matrix. Cancer Res 47: 6751–6762

    PubMed  CAS  Google Scholar 

  • Mussoni L, Poggi A, de Gaetano G, Donati MB (1978) Effect of ditazole, an inhibitor of platelet aggregation, on a metastasizing tumour in mice. Br J Cancer 37: 126–129

    CAS  Google Scholar 

  • Nicolson GL (1988) Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev. 7, 143–188.

    Article  PubMed  CAS  Google Scholar 

  • Nistér M, Heldin C-H, Westermark B (1986) Clonal varation in the production of a platelet-derived growth factor-like protein and expression of corresponding receptors in a human malignant glioma. Cancer Res 46: 332–340

    PubMed  Google Scholar 

  • Pearlstein E, Cooper LB, Karpatkin S (1979) Extraction and characterization of a platelet-aggregating material from SV40transformed mouse 3T3 fibroblasts. J Lab Clin Med 93: 332–344

    PubMed  CAS  Google Scholar 

  • Pearlstein E, Salk PL, Yogeeswaran G, Karpatkin S (1980) Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line. Proc Natl Acad Sci USA 77: 4336–4339

    Article  PubMed  CAS  Google Scholar 

  • Pearlstein E, Ambrogio C, Gasic G, Karpatkin S (1981) Inhibition of the platelet aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor: Dansylarginine N-(3-ethyl-1,5-pentanediyl) amide. Cancer Res 41: 4535–4539

    PubMed  CAS  Google Scholar 

  • Phillips DR, Charo IF, Parise LV, Fitzgerald LA (1988) The platelet membrane glycoprotein IIb-IIIa complex. Blood 71: 831–843

    PubMed  CAS  Google Scholar 

  • Pierschbacher MD and Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309: 30–33

    Article  PubMed  CAS  Google Scholar 

  • Poggi A, Polentarutti N, Donati MB, de Gaetano G, Garattini S (1977) Blood coagulation changes in mice bearing Lewis lung carcinoma,a metastasizing tumor. Cancer Res 37: 272–277

    CAS  Google Scholar 

  • Poggi A, Donati MB, Garattini S (1981) Fibrin and cancer cell growth: Problems in the evaluation of experimental models. In: Donati MB, Davidson JF, Garattini S (eds) Malignancy and the Hemostatic System, Raven Press, New York, N.Y., pp 89–101

    Google Scholar 

  • Poggi A, Vicenzi E, Cioce V, Wasteson A (1988) Platelet contribution to cancer cell growth and migration: the role of platelet growth factors. Haemostasis 18: 18–28

    PubMed  CAS  Google Scholar 

  • Poste G, Fidler I (1980) The pathogenis of cancer metastasis. Nature 283: 139–146

    Article  PubMed  CAS  Google Scholar 

  • Rickles FR, Hancock WW (1988) Antimetastatic Agents. II. Summary of the interactions of tumor cells with blood coagulation factors, platelets, fibrinolytic factors, and inflammatory cells and their soluble mediators: potential for therapeutic interventions. Seminars in Thrombosis and Hemostasis 14: 126–132

    Article  PubMed  CAS  Google Scholar 

  • Roberts DD, Sherwood JA, Ginsburg V (1987) Platelet thrombospondin mediates attachment and spreading of human melanoma cells. J Cell Biol 104: 131–139

    Article  PubMed  CAS  Google Scholar 

  • Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growth factor. Cell 46: 155–169

    Article  PubMed  CAS  Google Scholar 

  • Ruoslahti E and Pierscbacher MD (1987) New perspectives in cell adhesion: RGD and integrins. Science 238: 491–497

    Article  PubMed  CAS  Google Scholar 

  • Saiki I, Murata J, Iida J, Sakurai T, Nishi N, Matsuno K, Azuma I (1989) Antimetastatic effect of synthetic polypeptides containing repeated structures of the cell adhesive arg-gly-asp (RGD) and tyrile-gly-ser-arg ( YIGSR) sequences. Br J Cancer 60: 722–728

    Google Scholar 

  • Sporn MB, Roberts AB (1986) Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 78: 329–332

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Roberts AB, Wakefield LM, Assoian RK (1986) Transforming growth factor-beta: biological function and chemical structure. Science 233: 532–534

    Article  PubMed  CAS  Google Scholar 

  • Terranova VP, Hujanen ES, Martin GR (1986) Basement membrane and the invasive activity of metastatic tumor cells. J Natl Cancer Inst 77: 311–316

    PubMed  CAS  Google Scholar 

  • Tanaka NG, Tohgo A, Ogawa H (1986) Platelet-aggregating activities of metastasizing tumor cells. V. In situ role of platelets in hematogenous metastases. Invasion Metastasis 6: 58–68

    Google Scholar 

  • Tuszynski GP, Rothman VL, Murphy A, Seigler K, Smith L, Smith S, Karczeweski J, Knudesn K (1987a) Thrombospondin promotes cell-substratum adhesion. Science 236: 1570–1573

    Article  PubMed  CAS  Google Scholar 

  • Tuszynski GP, Gasic TB, Rothman VL, Knudsen K, Gasis GJ (1987b) Thrombospondin, a potentiator of tumor cell metastasis. Cancer Res 47: 4130–4133

    PubMed  CAS  Google Scholar 

  • Ugen KE, Mahalingam M, Klein PA, Kao K-J (1988) Inhibition of tumor cell-induced platelet aggregation and experimental tumor metastasis by the synthetic gly-arg-gly-asp-ser peptide. J Natl Cancer Inst 80: 1461–1466

    Article  PubMed  CAS  Google Scholar 

  • Vicenzi E, Lampugnani MG, Bolognese Dalessandro AP, Niewiarowska A, de Gaetano G, Donati MB (1987) Dissociation between thromboxane generation and metastatic potential in cells from a murine fibrosarcoma. Studies with a selective thromboxane synthase inhibitor. Int J Cancer 39: 488–491

    Google Scholar 

  • Warren BA (1981) Cancer cell-endothelial reactions: the microinjury hypothesis and localized thrombosis in the formation of micrometastases. In: Donati MB, Davidson JE, Garattini S (eds) Malignancy and the hemostasic system. Raven Press, New York 5–26

    Google Scholar 

  • Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C-H, Huang JS, Deuel TT (1983) Platelet-derived growth factor is structurally related to the putative transforming protein p28 sis of simian sarcoma virus. Nature 304: 35–39

    Article  PubMed  CAS  Google Scholar 

  • Weiss L, Orr WF, Honn KV (1989) Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis. Clin Expl Metastasis 7: 127–167

    Article  CAS  Google Scholar 

  • Westermark B, Johnsson A, Paulsson Y, Betsholtz C, Heldin C-H, Helyn M, Rodeck U, Koprowski H (1986) Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor ( PDGF) and produce a PDGF-like growth factor. Proc Natl Acad Sci USA 83: 7197–7200

    Google Scholar 

  • Wood S (1958) Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber. AMA Archives of Pathology 66: 550–568

    PubMed  Google Scholar 

  • Wood S, Hilgard P (1972) Aspirin and tumour metastasis. Lancet 2: 713.

    Google Scholar 

  • Zacharski LR, Henderson WG et al (1981) Effect of warfarin on survival in small cell carcinoma of the lung.Veterans Administration Study n.75. JAMA 245: 831–835.

    Article  PubMed  CAS  Google Scholar 

  • Zacharski LR, Moritz TE et al (1988) Effect of mopidamol on survival in carcinoma of the lung and colon:final report of Veterans Administration cooperative study No.188. J Natl Cancer Inst 80: 9097

    Google Scholar 

  • Zacharski LR, Donati MB (1989) Registry of clinical trials of antithrombotic drugs in cancer. Thromb Haemost 61: 526–528

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Consorzio Mario Negri Sud, Via Nazionale, I-66030, S. Maria Imbaro (Chieti), Italy

    Andreina Poggi, Lucia Beviglia, Cosmo Rossi & Maria Benedetta Donati

  2. DRF/LBio/Hématologie, Unité INSERM 217, C.E.N.G. 85X, F-38041, Grenoble Cedex, France

    Marie Hélène Charon & Gerard Marguerie

Authors
  1. Andreina Poggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucia Beviglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marie Hélène Charon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cosmo Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gerard Marguerie
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria Benedetta Donati
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. I. Medizinische Klinik, Fakultät Klinische Medizin Mannheim, Ruprecht-Karls-Universität Heidelberg, Theodor-Kutzer-Ufer, 6800, Mannheim, Germany

    Job Harenberg , Dieter L. Heene  & Gerd Stehle ,  & 

  2. Karlstraße 4, 6900, Heidelberg, Germany

    Gotthard Schettler (Leiter, Präsident der Heidelberger Akademie der Wissenschaften (bis 30.9 1990) (Leiter, Präsident der Heidelberger Akademie der Wissenschaften (bis 30.9 1990)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Poggi, A., Beviglia, L., Charon, M.H., Rossi, C., Marguerie, G., Donati, M.B. (1990). Anti-Platelet Treatment of Metastasis. In: Harenberg, J., Heene, D.L., Stehle, G., Schettler, G. (eds) New Trends in Haemostasis. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1990 / 1990/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84318-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84318-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53275-0

  • Online ISBN: 978-3-642-84318-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation