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Die allergischen Atemwegsobstruktionen: Organmanifestation und klinischer Verlauf

  • G. Schultze-Werninghaus
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für Innere Medizin book series (VDGINNERE, volume 96)

Zusammenfassung

Morphologisches Korrelat des Asthma bronchiale ist eine besondere Form der Entzündung der Atemwegsmukosa, bei der — auch in leichteren Krankheitsstadien — Epithelläsion, Ödem und Zellinfiltrat mit eosinophilen und neutrophilen Granulozyten wie auch Lymphozyten sowie eine subepitheliale KoUagenfaservermehrung („Verdickung der Basalmembran“) nachweisbar sind [1, 28]. Welche dieser Veränderungen mit dem kennzeichnenden funktionellen Befund des Asthmas, der Hyperreagibilität, in ursächlichem Zusammenhang steht, ist bisher unklar. Im angelsächsischen Sprachraum ist wegen der angenommenen herausragenden Bedeutung eosinophiler Granulozyten z.Z. die Definition des Asthmas als „eosinophile Bronchitis“ populär. Es bleibt jedoch festzuhalten, daß dieser Terminus das Asthma nur unzureichend beschreibt, da u.a. nicht jedes Asthma mit Eosinophilie und nicht jede Atemwegseosinophilie mit Asthma verbunden ist. Das eigentliche morphologische Korrelat des Asthmas, sofern existent, ist bisher nicht definiert.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • G. Schultze-Werninghaus
    • 1
  1. 1.Abteilung für Pneumologie, Zentrum der Inneren MedizinUniversitätsklinikumFrankfurt/MainDeutschland

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