Clinical Interpretation of Urinary Enzyme Excretion

  • J. E. Scherberich


It is the purpose of the present chapter to summarize the general clinical and pathophysiological background which underlies the release of enzymes of renal origin into urine under pathological conditions. These aspects are compiled in Table 1 and Fig. 1.


Urinary Enzyme Renal Functional Reserve Alanine Aminopeptidase High Osmolar Contrast Medium Human Kidney Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bourgoignie JJ (1989) Acquired immunodeficiency syndrome (AIDS)-related renal disease. Klin Wochenschr 67:889–894.PubMedCrossRefGoogle Scholar
  2. 2.
    Cal JC, Dorian C, Catroux P, Cambar J (1989) Nephrotoxicity of heavy metals and antibiotics. In: Lemmer B (ed) Chronopharmacology. Marcel Dekker, New York, pp 655–681.Google Scholar
  3. 3.
    Chan L, Schrier RW (1990) Effects of calcium channel blockers on renal function. Annu Rev Med 41:289–302.PubMedCrossRefGoogle Scholar
  4. 4.
    Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH (1990) Proteinases and the glomerulus: their role in glomerular diseases. Klin Wochenschr 68:1145–1149.PubMedCrossRefGoogle Scholar
  5. 5.
    Diener U, Knoll E, Langer B, Rautenstrauch H, Ratge D, Wisser H (1981) Urinary excretion of N-acetyl-β-D-glucosaminidase and alanine aminopeptidase in patients receiving amikacin or cis-platinum. Clin Chim Acta 112:149–157.PubMedCrossRefGoogle Scholar
  6. 6.
    Dubach UC, Schmidt U (eds) (1979) Diagnostic significance of enzymes and proteins in urine. Hans Huber, Bern (Curr Probl Clin Biochem 9).Google Scholar
  7. 7.
    Fine L (1986) The biology of renal hypertrophy. Kidney Int 29:619–634.PubMedCrossRefGoogle Scholar
  8. 8.
    Habenicht A (ed) (1990) Growth factors, differentiation factors and cytokines. Springer, Berlin Heidelberg New York.Google Scholar
  9. 9.
    Heinert G, Wyrobnik J, Scherberich JE (1980) Quantitative computed histophotometry of membrane-integrated and lysosomal enzymes indicating inductive and alternative effects of aminoglycosides. Curr Chemother Immunother 11:252–254.Google Scholar
  10. 10.
    Heinert G, Scherberich JE, Mondorf W, Weber W (1983) Quantitative enzymatic and immunologic computer-assisted histophotometry of human kidney tissue following neoplastic and other clinically significant alterations. Eur Urol 9:235–241.PubMedGoogle Scholar
  11. 11.
    Jung K, Schulze BD, Sydow K (1987) Diagnostic significance of different urinary enzymes in patients suffering from chronic renal diseases. Clin Chim Acta 168:287–293.PubMedCrossRefGoogle Scholar
  12. 12.
    Maruhn D, Paar D (1982) Urinary enzymes in therapy monitoring and recognition of side effects of drugs. Clin Enzymol Symp 3:137–152.Google Scholar
  13. 13.
    Mattenheimer H (1977) Enzymes in renal diseases. Ann Clin Lab Sci 7:422–432.PubMedGoogle Scholar
  14. 14.
    Mondorf W, Scherberich JE, Falkenberg FW (1984) Brush border enzymes and drug nephrotoxicity. In: Solez K, Whelton A (eds) Acute renal failure. Marcel Dekker, New York, pp 281–292.Google Scholar
  15. 15.
    Paddock JK, Taddeo AR, Paddock JP, Loewenstein LM (1985) Glycoprotein reutilisation in regenerating microvilli after renal ischaemia in rats. Kidney Int 28:498–503.PubMedCrossRefGoogle Scholar
  16. 16.
    Rodicio JL, Morales JM, Ruilope LM (1990) Calcium antagonists and the kidney. Nephrol Dial Transplant 5:81–86.PubMedGoogle Scholar
  17. 17.
    Scherberich JE (1990) Urinary proteins of tubular origin: basic immunochemical and clinical aspects. Am J Nephrol 10 [Suppl 1]:43–51.PubMedCrossRefGoogle Scholar
  18. 18.
    Scherberich JE, Gauhl C, Heinert G, Mondorf W, Schoeppe W (1984) Characterization and clinical significance of membrane bound proteases from human kidney cortex. Adv Exp Med Biol 167:179–190.PubMedGoogle Scholar
  19. 19.
    Scherberich JE, Wolf G, Albers C, Nowack A, Stuckhardt C, Schoeppe W (1989) Glomerular and tubular membrane antigens reflecting cellular adaptation in human renal failure. Kidney Int 36 [Suppl 27]:S38–S51.Google Scholar
  20. 20.
    Scherberich JE, Rautschka E, Fischer A, Kollath J, Riemann HE (1990) Tubular histuria: clinical evaluation of the different nephrotoxic potential of x-ray contrast media. Contr Nephrol 83:229–236.Google Scholar
  21. 21.
    Scherberich JE, Schneider A, Nockher A, Staszewski S, Schoeppe W (1991) Pattern of serum-and kidney-specific proteinuria in patients with HIV-infection. Kidney Int 39:1312.Google Scholar
  22. 22.
    Weinberg JM (1991) The cell biology of ischaemic renal injury. Kidney Int 39: 476–500.PubMedCrossRefGoogle Scholar
  23. 23.
    Wolf G, Neilson EG (1991) Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am J Physiol 259:F768–F777.Google Scholar
  24. 24.
    Wolf G, Neilson EG (1991) Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int 39:401–420.PubMedCrossRefGoogle Scholar
  25. 25.
    Wolf G, Scherberich JE, Nowack A, Stein O, Schoeppe W (1990) Urinary excretion of dipeptidyl aminopeptidase IV in patients with renal diseases. Clin Nephrol 35:136–142.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. E. Scherberich

There are no affiliations available

Personalised recommendations