Optical Imaging of Neuronal Activity in the Living Brain

  • R. D. Frostig
  • E. E. Lieke
  • A. Arieli
  • D. Y. Ts’o
  • R. Hildesheim
  • A. Grinvald
Part of the Springer Series in Synergetics book series (SSSYN, volume 49)


In this book questions regarding neuronal populations were primarily investigated using single- and multi-unit recordings with electrodes. The complexity of the functional organization which is revealed by these studies indicates a need for new methods which could obtain complementary information that is hard or impossible to obtain with microelectrodes. Imaging methods that provide high spatial or temporal resolution maps of the cortical organization of large cortical areas are of particular promise for studies of functional organization.


Optical Signal Optical Recording Intrinsic Signal Neuronal Assembly Photo Diode Array 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Arieli, A., Frostig, R.D., Lieke, E., Hildesheim, R., Grinvald, A. (1987): Soc. Neurosci. Abstr. 13, 52.Google Scholar
  2. Arieli, A., Grinvald, A. (1988): Soc. Neurosci. Abstr. 14, 1122Google Scholar
  3. Blasdel, G.G., Salama, G. (1986): Nature 321, 579CrossRefADSGoogle Scholar
  4. Chance, B., Cohen, P., Jobsis, F., Schonener, B. (1962): Science 137, 499CrossRefADSGoogle Scholar
  5. Cohen, L.B. (1973): Physiol. Rev. 53, 373Google Scholar
  6. Cohen, L.B., Lesher, S. (1986): Soc. Gen. Physiol. Ser. 40, 71Google Scholar
  7. De Weer, P., Salzberg, B.M. (1986): Eds. Soc. Gen. Physiol. Ser. Vol. 40( Wiley, New York )Google Scholar
  8. Egger, M.D., Petran, M. (1967): Science 157, 305CrossRefADSGoogle Scholar
  9. Frost, J.D. (1986): Electroenceph. clin. Neurophysiol. 24, 434Google Scholar
  10. Frostig, R.D., Lieke, E.E., Ts’o, D.Y., Grinvald, A. (1988): Soc. Neurosci. Abstr. 14, 897Google Scholar
  11. Frostig, R.D., Gilbert, C.D., Ts’o, D.Y., Grinvald, A., Wiesel, T.N. (1989): Soc. Neurosci. Abstr. 15, 799Google Scholar
  12. Frostig, R.D., Lieke, E.E., Ts’o, D.Y., Grinvald, A. (1990): Proc. Natl. Acad. Sci. USA 87, 6082CrossRefGoogle Scholar
  13. Gilbert, C.D., Wiesel, T.N. (1983): Neurosci. 3, 116Google Scholar
  14. Grinvald, A. (1984): Trends in Neurosci. 7, 143CrossRefGoogle Scholar
  15. Grinvald, A., Anglister, L., Freeman, J.A., Hildesheim, R., Manker, A. (1984): Nature 308, 848CrossRefADSGoogle Scholar
  16. Grinvald, A., Cohen, L.B., Lesher, S., Boyle, M.B. (1981): J. Neurophysiol. 45, 829Google Scholar
  17. Grinvald, A., Frostig, R.D., Lieke, E., Hildesheim, R. (1988): Physiol. Rev. 68, 1285Google Scholar
  18. Grinvald, A., Gilbert, C.D., Hildesheim, R., Lieke, E., Wiesel, T.N. (1985): Soc. Neurosci. Abstr. 11, 8Google Scholar
  19. Grinvald, A., Lieke, E., Frostig, R.D., Gilbert, C.D., Wiesel, T.N. (1986): 324, 361Google Scholar
  20. Grinvald, A., Manker, A., Segal, M. (1982): J. Physiol. 333, 269Google Scholar
  21. Gross, D., Loew, L.M., Webb, W.W. (1985): Biophys. J. 47, 270aGoogle Scholar
  22. Gross, D., Webb, W.W. (1984): Biophys. J. 45, 269aGoogle Scholar
  23. Hill, D.K., Keynes, R.D. (1949): Physiol. 108, 278Google Scholar
  24. Hubel, D.H., Livingstone, M.S. (1987): J. Neurosci. 7, 3378Google Scholar
  25. Hubel, D.H., Wiesel, T.N. (1962): J. Physiol. 160, 106Google Scholar
  26. Jobsis, F.F., Keiser, J.H., LaManna, J.C., Rosenthal, M., (1977): J. Appt. Physiol: Respirat. Environ. Exercise Physiol.Google Scholar
  27. Kauer, J.S. (1988): Nature, 331, 166CrossRefADSGoogle Scholar
  28. Kelin, D. (1925): Proc. R. Soc. B 98, 312CrossRefADSGoogle Scholar
  29. Konnerth, A., Orkand, R.K. (1986): Proc. Natl. Acad Sci. USA 83, 6651CrossRefGoogle Scholar
  30. Lev-Ram, V., Grinvald, A. (1986): Proc. Natl. Acad Sci. USA 83, 6651CrossRefGoogle Scholar
  31. Lieke, E.E., Frostig, R.D., Ratzlaff, E.H., Grinvald, A. (1988): Soc. Neurosci. Abs. 14, 1122 Loew, L.M. (1987): Optical measurement of electrical activity (CRC Press, Boca Raton) Mayevsky, A., Chance, B. (1982): Science 217, 537Google Scholar
  32. Millikan, G.A. (1937): Proc. R. Soc. B 123, 218CrossRefADSGoogle Scholar
  33. Orbach, H.S. (1987): In Optical measurement of electrical activity. Ed. L.M. Loew ( CRC Press, Boca Raton )Google Scholar
  34. Nelson, J.I., Frost, B.J. (1985): Exp. Brain Res. 61, 54 (1985).Google Scholar
  35. Orbach, H.S., Cohen, L.B. (1983): J. Neurosci. 3, 2251Google Scholar
  36. Orbach, H.S., Cohen, L.B., Grinvald, A. (1985): J. Neurosci. 5, 1886Google Scholar
  37. Ross, W.N., Reichardt, L.F. (1979): J. Membr. Biol. 48, 343CrossRefGoogle Scholar
  38. Salzberg, B.M. (1983): In Current Methods in Cellular Neurobiology, Eds. J. Barber, J. McKelvy ( Wiley, New York )Google Scholar
  39. Salzberg, B.M., Obaid, A.L., Gainer, H. (1985): J. Gen. Physiol. 86, 395CrossRefGoogle Scholar
  40. Tasaki, I. Warashina, A. (1976): Photochem. Photobiol. 24 191CrossRefGoogle Scholar
  41. Ts’o, D.Y., Frostig, R.D., Lieke, E.E., Grinvald, A. (1988): Soc. Neurosci. Abstr. 14, 898Google Scholar
  42. Ts’o, D.Y., Gilbert, C.D., Wiesel, T.N. (1986): J. Neurosci, 6, 1160Google Scholar
  43. Ts’o, D.Y., Frostig, R.D., Lieke, E.E., Grinvald, A. (1990): Science 249, 333Google Scholar
  44. Waggoner, A.S. (1979): Bioener. 8, 47Google Scholar
  45. Waggoner, A.S., Grinvald, A. (1977): Ann. N.Y. Acad. Sci. 303, 217Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. D. Frostig
    • 1
  • E. E. Lieke
    • 2
  • A. Arieli
    • 3
  • D. Y. Ts’o
    • 4
  • R. Hildesheim
    • 3
  • A. Grinvald
    • 4
    • 5
  1. 1.Department of PsychobiologyUniversity of California at IrvineIrvineUSA
  2. 2.Institut für TierphysiologieNeurobiologieBerlin 33Germany
  3. 3.Dept. of NeurobiologyThe Weizmana Institute of ScienceRehovotIsrael
  4. 4.Laboratory of NeurobiologyThe Rockefeller UniversityNew YorkUSA
  5. 5.IBM Research DivisionYorktown Heights, New YorkUSA

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