Abstract
The central nervous system contains two populations of phagocytic cells: the non-resident phagocytes derived from circulating precursor cells and known as brain macrophages, and the ramified microglia, the origin of which remains controversial, that are considered as the resident macrophage population. These two classes of phagocytes are recruited in a different manner in response to local injury or infection of the brain, depending on the severity of brain lesion or of blood vessels damage (see reviews in Perry and Gordon 1988 and in Streit et al. 1988).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Austyn JM, Gordon S (1981) F 4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol: 805–815
Bocchini V, Rebel G, Masarelli R, Schuber F, Muller CD (1988) Latex beads phagocytosis capacity and ecto-NAD+ glycohydrolase activity of rat brain microglial cells in vitro. Int J Devel Neurosc 6: 525–534
Chamberlain J G (1974) Scanning electron microscopy of epiplexus cells (macrophages) in the fetal rat brain. Am J Anat 139: 443–447
Imamoto K, Fujiwara R, Nagai T, Maeda T (1982) Distribution and fate of macrophagic ameboid cells in the rat brain. Arch Histol Jap 45: 505–518
Kaneko Y, Kitamoto T, Tateishi J, Yamaguchi K (1989) Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathol 79: 129–136
Koski JR, Poplack DG, Blaese RM, (1976) In methods in cell mediated and tumors immunity. 359–362 Acad Press New-York
Mannoji H, Yeger H, Becker L E (1986) A specific histochemical marker (lectin Ricinus communis agglutinin-1) for normal human microglia, and application to routine histopathology. Acta Neuropathol 71: 341–343
Murabe Y, Sano Y (1982) Morphological studies on neuroglia: VI Postnatal development of microglial cells. Cell Tissue Res 225: 469–485
Perry V H, Gordon S (1988) Macrophages and microglia in the nervous system. TINS 11: 273–277
Rio Hortega P del, (1932) In Cytology and cellular pathology of the nervous system. 2: 482–534 PB Hoeber Inc New-York
Springer T, Galfre G, Secher DS, Milstein C (1979) Mac 1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 9: 301–306
Streit W J, Graeber M B, Kreutzberg GW (1988) Functional plasticity of microglia: a review. Glia 1: 301–307
Streit W J, Kreutzberg GW (1987) Lectin binding by resting and reactive microglia. J Neurocytol 16: 249–260
Wislocki G B, Leduc E H (1952) Vital staining of the hematoencephalic barrier by silver nitrate and trypan blue, and cytological comparisons of neurohypophysis, pineal body, area postrema, intercolumnar tubercle and supraoptic crest. J Comp Neurol 96: 371–413
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Delhaye-Bouchaud, N., Fardeau, C., Riva, I., Caron, S., Bouchaud, C. (1991). Characterization of Microglia and Brain Macrophages. In: Calas, A., Eugène, D. (eds) Neurocytochemical Methods. NATO ASI Series, vol 58. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84298-6_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-84298-6_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84300-6
Online ISBN: 978-3-642-84298-6
eBook Packages: Springer Book Archive