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Endocytosis pp 483-488 | Cite as

Lysosomes of Leishmania Mexicana Sp. as Targets for Potential Therapeutic Agents

  • Michel Rabinovitch
  • Claude Ramazeilles
  • Silvia C. Alfieri
  • Vladimir Zilberfarb
  • Elliot Shaw
  • Jair Ribeiro Chagas
  • Luiz Juliano
Conference paper
Part of the NATO ASI Series book series (volume 62)

Abstract

Hydrophobic amino acid esters and peptides disrupt lysosomes in cell-free fractions by a mechanism involving trapping by protonation, enzymatic hydrolysis and accumulation of less permeant products within the organelles (Goldman & Naider 1974; Ransom & Reeves 1983). Damage to lysosomes possibly accounts for the selective toxicity of the compounds for monocytes, NK cells and cytotoxic T cells. This toxicity may be due to ester conversion to membranolytic polymers catalysed by a dipeptidyl-peptidase I (Thiele & Lipsky 1990 a, b).

Keywords

Cysteine Proteinase Amino Acid Ester Antileishmanial Activity Cysteine Proteinase Activity Amino Acid Amide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Michel Rabinovitch
    • 1
  • Claude Ramazeilles
    • 1
  • Silvia C. Alfieri
    • 2
  • Vladimir Zilberfarb
    • 1
  • Elliot Shaw
    • 3
  • Jair Ribeiro Chagas
    • 4
  • Luiz Juliano
    • 4
  1. 1.Institut Pasteur and CNRS UA 361ParisFrance
  2. 2.Department of ParasitologyUniversity of Sao PauloSao PauloBrazil
  3. 3.Friedrich Miescher InstitutBaselSwitzerland
  4. 4.Department of BiophysicsEscola Paulista de MedicinaSao PauloBrazil

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