Abstract
When microbes penetrate our organism, they are generally rapidly eliminated by polymorphonuclear leukocytes or macrophages. However, pathogenic bacteria and protozoars have developed different strategies to escape the microbicidal properties of these phagocytes. Some avoid ingestion by macrophages or kill them by excreting toxins, whereas others are ingested by the macrophage, in which they are able to survive and multiply despite the microbicidal properties of this phagocyte.
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References
Armstrong J.A. & d’Arcy Hart P.D. (1975) Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual non-fusion pattern and observations on bacterial survival. J. Exp. Med. 142, 1–16
Frehel C, de Chastellier C., Lang T. & Rastogi N. (1986) Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium. Infect. Immun. 52, 252–262.
Frehel C., & Rastogi N. (1987) Mycobacterium leprae surface components intervene in the early phagosome-lysosome fusion inhibition event. Infect. Immun. 55, 2916–2921.
Frehel C., Ryter A., Rastogi N., & David H. (1986 b) The electron transparent zone in phagocytized Mycobacterium avium and other Mycobacteria Formation, persistence and role in bacterial survival Ann. Inst. Pasteur. 137 B, 238–257.
Horwitz M. (1983a) Formation of a novel phagosome by the Legioniaires’ disease bacterium (Legionella pneumophila) in humanmonocytes. J. Exp. Med. 158, 1319_1331
Horwitz M. (1983 b) The Legiuonaires’ bacterium (Legionella pneumonphila) inhibits phagosome-lysosome fusion in human monocytes. J. Exp. Med. 158, 2108–2126.
Horwitz M (1984) Phagocytosis of Legionaires’ disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell. 36, 27–33.
Jones T.C. & Hirsch J.G. (1872) The interaction between Toxoplasma gondii and mammalian cells. II The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J. Exp. Med. 136, 1173–1180
Mounier J., Ryter A., Coquis-Rodon M. & Sansonetti P.J. (1990) Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2. Infect. Immun. 58, 1048–1058.
Popiel I. & Turnbull P. (1985) Passage of Salmonella enteriditis and Salmonella thompson through chick ileovecal mucosa. Infect. Immun. 47, 786–792.
Rikihisa Y., & Ito S. (1979) Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes. J. Exp. Med. 150, 703–708.
Ryter A., & de Chastellier C. (1983) Phagocyte-pathogenic microbe interactions. Intern. Rev. Cytol. 85, 287–327.
Sansonetti P.J., Ryter A., Clerc P.; Maurelli A.T. & Mounier J. (1986) Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid mediated contact hemolysis. Infect. Immun. 51, 461–469.
Silverman D.J.,& Wisseman C.L. (1979) In vitro studies of rickettsia-host cell interactions: ultrastructural changes induced by Rickettsia rickettsii infection of chicken embryo fibroblasts. Infect. Immun. 26, 714–727.
Tilney L.G. & Portnoy D.A. (1989) Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria moncytogenes. J. Cell Biol. 109, 1597–1608.
Wilson C.B., van Tsai V. & Remington J.S. (1980). Failure to trigger the oxidative metabolic burst by normal macrophages. Possible mechanism for survival of intracellular pathogens. J. Exp. Med. 151, 328–334.
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© 1992 Springer-Verlag Berlin Heidelberg
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Ryter, A. (1992). Overview on the Relations of Pathogenic Microorganisms with their Host Cell. In: Courtoy, P.J. (eds) Endocytosis. NATO ASI Series, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84295-5_46
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DOI: https://doi.org/10.1007/978-3-642-84295-5_46
Publisher Name: Springer, Berlin, Heidelberg
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