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Role of Transepithelial Transport in Triggering a Mucosal Immune Response and in Delivery of Mucosal Antibodies into Secretions

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Endocytosis

Part of the book series: NATO ASI Series ((ASIH,volume 62))

Abstract

Many pathogens, including viruses, bacteria and parasites as well as toxins and allergens, gain entry into the organism by crossing the epithelia of the digestive, respiratory or genital tracts. Mucosal surfaces are protected against environmental pathogens by non immune and immune mechanisms (Mayrhofer, 1984). A distinct “mucosal” immune system plays a major role in protection, and an important component of this protection is production of secretory antibodies of the IgA isotype (slgA) (Russel and Mestecky, 1988).

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© 1992 Springer-Verlag Berlin Heidelberg

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Kraehenbuhl, J.P., Michetti, P., Hirt, R., Perregaux, C., Mekalanos, J., Neutra, M. (1992). Role of Transepithelial Transport in Triggering a Mucosal Immune Response and in Delivery of Mucosal Antibodies into Secretions. In: Courtoy, P.J. (eds) Endocytosis. NATO ASI Series, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84295-5_45

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  • DOI: https://doi.org/10.1007/978-3-642-84295-5_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84297-9

  • Online ISBN: 978-3-642-84295-5

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