Endocytosis pp 343-353 | Cite as

Endocytosis: Molecular Mechanism and Role in the Immune Response

  • F. M. Brodsky
  • L. E. Guagliardi
  • C. J. Galloway
  • B. Koppelman
  • S. L. Acton
  • D. H. Wong
  • I. Näthke
Conference paper
Part of the NATO ASI Series book series (volume 62)

Abstract

Clathrin-mediated endocytosis is responsible for selective and facilitated internalization of cell surface receptors (Brodsky, 1988). This process contributes to the uptake of nutrients and hormones and targets internalized proteins and their receptors to degradative and/or recycling intracellular compartments. Antigenic fragments of internalized proteins are generated as a byproduct of this pathway and bind to histocompatibility molecules which present them to T cells, thereby stimulating the immune response. The research summarized below investigates the molecular control of clathrin-mediated endocytosis and its participation in the intracellular events that lead to antigen processing and presentation.

Keywords

Hydrolysis Magnesium Cage Tyrosine Leukemia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • F. M. Brodsky
    • 1
  • L. E. Guagliardi
    • 1
  • C. J. Galloway
    • 1
  • B. Koppelman
    • 1
  • S. L. Acton
    • 1
  • D. H. Wong
    • 1
  • I. Näthke
    • 1
  1. 1.Departments of Pharmacy and Pharmaceutical Chemistry, School of PharmacyUniversity of CaliforniaSan FranciscoUSA

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