Endocytosis: Molecular Mechanism and Role in the Immune Response
Clathrin-mediated endocytosis is responsible for selective and facilitated internalization of cell surface receptors (Brodsky, 1988). This process contributes to the uptake of nutrients and hormones and targets internalized proteins and their receptors to degradative and/or recycling intracellular compartments. Antigenic fragments of internalized proteins are generated as a byproduct of this pathway and bind to histocompatibility molecules which present them to T cells, thereby stimulating the immune response. The research summarized below investigates the molecular control of clathrin-mediated endocytosis and its participation in the intracellular events that lead to antigen processing and presentation.
KeywordsLight Chain Free Light Chain Coated Vesicle Invariant Chain Calcium Binding Site
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