Endocytosis: Molecular Mechanism and Role in the Immune Response
Clathrin-mediated endocytosis is responsible for selective and facilitated internalization of cell surface receptors (Brodsky, 1988). This process contributes to the uptake of nutrients and hormones and targets internalized proteins and their receptors to degradative and/or recycling intracellular compartments. Antigenic fragments of internalized proteins are generated as a byproduct of this pathway and bind to histocompatibility molecules which present them to T cells, thereby stimulating the immune response. The research summarized below investigates the molecular control of clathrin-mediated endocytosis and its participation in the intracellular events that lead to antigen processing and presentation.
KeywordsHydrolysis Magnesium Cage Tyrosine Leukemia
Unable to display preview. Download preview PDF.
- Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (eds) (1989) Molecular Biology of the Cell, 2nd ed., Garland Publishing, Inc., New York and LondonGoogle Scholar
- Babu YS, Brugg CE, Cook WJ (1988) in Three dimensional structure of calmodulin (Cohen, P. and Klee, C. B., eds) pp. 83–89, Elsevier, AmsterdamGoogle Scholar
- Brodsky FM, Guagliardi L (1991) The cell biology of antigen processing and presentation. Annu. Rev. Immunol. 9: in pressGoogle Scholar
- Morré DJ (1982) in Intracellular transport: vehicles, guide elements, and mechanisms (Weiss, D., ed) pp. 2–14, Springer-Verlag, BerlinGoogle Scholar
- Rasmussen H, Kojima I, Kojima K, Zawalich W, Apfeldorf W (1984) Calcium as intracellular messenger: sensitivity, modulation, C-kinase pathway, and sustained cellular response. Adv. Cycl. Nucleotide and Prot. Res. 18: 159–193Google Scholar
- Usami M, Takahashi A, Kadota T, Kadota K (1985) Phosphorylation of a clathrin light chain of coated vesicles in the presence of histones. J. Biochem. 92:1819–1822Google Scholar