Abstract
In I-cell fibroblasts deficient in the phosphotransferase activity generating mannose 6-phosphate markers of lysosomal enzymes intralysosomal activities of most lysosomal enzymes are deminished severely (Neufeld and McKusick 1983) whereas intralysosomal LAP activities are normal (Gieselmann et al 1984) suggesting that LAP is targeted to lysosomes independently of mannose 6-phosphate receptors. Furthermore segregation of LAP to lysosomes is neither affected by antibodies blocking the mannose 6-phosphate/IGF II receptor nor by NH4CI known to inhibit the mannose 6-phosphate receptor dependent targeting of soluble lysosomal enzymes (Gottschalketal 1989).
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Peters, C. et al. (1992). The nineteen amino acid cytoplasmic tail of lysosomal acid phosphatase contains an endocytosis signal necessary and sufficient for targeting to lysosomes. In: Courtoy, P.J. (eds) Endocytosis. NATO ASI Series, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84295-5_26
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DOI: https://doi.org/10.1007/978-3-642-84295-5_26
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