Analysis of Receptor Dynamics, as Studied with Surface Replicas
Cells interact in a variety of ways with their environment. One essential type of interaction involves the recognition by cells of a wide variety of polypeptides in the surrounding milieu. At the surface of a cell, these molecules are recognized and bound. This process is receptor-mediated and is the first step in the physiologic signaling and/or internalization of the ligand. Investigations on the complement and distribution of receptors at the cell surface are of great significance for determining how receptors modulate cellular activities. The increased interest in studying cell surface receptors in recent years has sparked the improvement of morphological methods and the development of visual probes for localizing receptor sites in the electron microscope.
KeywordsGold Particle Colloidal Gold Patch Formation Hepatocyte Plasma Membrane Surface Replica
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