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Endocytosis pp 91-95 | Cite as

Endosomal pH Regulation and the Maturation Model for Lysosome Biogenesis

  • Robert F. Murphy
  • Mario Roederer
  • David M. Sipe
  • Cynthia Corley Cain
  • Russell B. Wilson
Part of the NATO ASI Series book series (volume 62)

Abstract

The mechanisms by which the recycling and degradation of endocytosed material are regulated have been the subject of intense study since the initial description of lysosomes (for reviews see Steinman et al 1983; von Figura & Hasilik 1986). While a number of questions remain, significant evidence points to the important role played by low in controlling and facilitating processing of endocytosed ligands. The dissociation of many ligand-receptor complexes is induced by acidification below 7, and many lysosomal hydrolases have low optima (Mellman et al 1986). Within the last five years, it has become clear that, at least in many non-erythroid cells, the to which material destined for lysosomes is exposed decreases continuously with time after internalization (Murphy et al 1984; Roederer & Murphy 1986; Kielian et al 1986; Roederer et al 1987; Yamashiro & Maxfield 1987).

Keywords

Lysosomal Enzyme Early Endosome Endosome Acidification Maturation Model Cell BioI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Robert F. Murphy
    • 1
  • Mario Roederer
    • 1
  • David M. Sipe
    • 1
  • Cynthia Corley Cain
    • 1
  • Russell B. Wilson
    • 1
  1. 1.Department of Biological Sciences & Center for Fluorescence Research in Biomedical SciencesCarnegie Mellon UniversityPittsburghUSA

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