The Use of Psychotropic Medications in Persons with Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is an unusual and multifacted birth defect characterized by severe hypotonia, hypogenitalism, delayed development, and mental retardation (Prader et al, 1956; Zellweger and Schneider, 1968; Zellweger 1988). Hyperphagia becomes evident early in childhood and is accompanied by predisposition to increasingly unstable emotions and behavior Problems that intensify over time (Sulzbacher, 1988). If the insatiable appetite is left unmanaged, affected individuals may become morbidly obese and die of complications of obesity. A no less important component of the Syndrome is the evolution over time of inappropriate and often bizarre behaviors that escalate in frequency and intensity with age, necessitating ongoing management and Intervention (Greenswag, 1987). Anecdotal reports of chemical management of these behaviors, accompanied by conflicting opinions regarding their appropriateness and effectiveness, are emerging. No data exists to guide clinicians’ choice of medication, dosage, Potential side effects, and time frame for administration. Moreover, information comparing the effectiveness of psychotropic medications with non-drug behavioral Intervention is not available.
KeywordsBehavior Problem Psychotropic Medication Psychotropic Drug Group Home Minnesota Department
Unable to display preview. Download preview PDF.
- Cassidy SB (1991) Personal communicationGoogle Scholar
- Minnesota Department of Public Weifare (1980) The Use of Medications in Controlling the Behavior of the Mentally Retarded. Proceedings of the conference on the Use of Medications in Controlling the Behavior of the Mentally Retarded. Sponsored by the Department of Public Weifare, State of Minnesota, September 22–24, 1980Google Scholar
- Prader A, Labhart A and Willi H (1956) Ein Syndrom von Adipositas, Kleinwuchs, Kryptochismus und Oligophrenie nach Myatonieartigem Zustand im Neugeborenalter. Schweiz Med Wochenschr 86: 1260-1261Google Scholar
- Whitman BY and Accardo P (1987) Emotional symptoms in Prader-Willi adolescents. Am J Med Genet 4 (1): 636–638Google Scholar