Abstract
Since its introduction at the end of the 1950s, gas chromatography (GC) has developed into a versatile tool in the analysis of natural products. Clear advantages of GC are the high resolution and high sensitivity of the most common detection method, the flame ionization detector (FID), and the fact that the detector response of similar compounds will be about the same, i.e., peak areas may be directly compared for quantification. This is in contrast to high performance liquid chromatography (HPLC), in which the detector response in the most common detection mode, ultra violet (UV)-absorption, may vary widely for different compounds since the molar extinction coefficients can be very different.
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Dagnino, D., Verpoorte, R. (1994). Gas Chromatography in the Analysis of Alkaloids. In: Linskens, H.F., Jackson, J.F. (eds) Alkaloids. Modern Methods of Plant Analysis, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84226-9_4
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