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Amyloid ßA4 protein deposition in Alzheimer’s disease and Down’s Syndrome

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Molecular Mechanisms of Aging

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Abstract

Alzheimer’s disease (AD) is characterized by the deposition of amyloid fibrillar aggregates in the intracellular and extracellular neuronal compartments. The factors which determine the topographic distribution of the lesions within the brain and the balance of amyloid deposition between extracellular and intracellular compartments are not yet understood. A certain proportion of AD patients have a family history of disease, some of which are clearly autosomal dominant and result in an earlier than usual age at onset and death (Masters et al 1981). Identification of a gene responsible for this form of familial AD (the FAD gene) would provide great insight into the mechanism of AD. The well-established association between Down’s syndrome (DS) and the premature development of AD also points to a gene-dosage effect arising from chromosome 21.

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Authors and Affiliations

  1. Department of Pathology, University of Melbourne, Parkville, Victoria, 3052, USA

    Colin L. Masters & Konrad Beyreuther

  2. Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria, 3052, USA

    Colin L. Masters & Konrad Beyreuther

  3. Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, Federal Republic of Germany

    Konrad Beyreuther

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  1. Colin L. Masters
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  1. Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 282, 6900, Heidelberg, Germany

    Konrad Beyreuther

  2. Karlstraße 4, 6900, Heidelberg, Germany

    Gotthard Schettler (Leiter, Präsident der Heidelberger Akademie der Wissenschaften) (Leiter, Präsident der Heidelberger Akademie der Wissenschaften)

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Masters, C.L., Beyreuther, K. (1990). Amyloid ßA4 protein deposition in Alzheimer’s disease and Down’s Syndrome. In: Beyreuther, K., Schettler, G. (eds) Molecular Mechanisms of Aging. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1990 / 1990/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84224-5_14

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