Abstract
In the past decade a rapid progress has been achieved in the isolation and characterization of a number of bioactive peptides from the brain, mostly from the hypothalamus, and the gastrointestinal tract. These peptides are known to influence and regulate many physiological processes in a variety of animal and human tissues. One of the peptides, that has received increasing attention in recent years, is somatostatin.
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References
Arneric SP, and Reis DJ (1986) Somatostatin and colecystochinin octapeptide differentially modulate the release of (3H)-acetylcholine from caudate nucleus but not cerebral cortex: role of dopamine receptor activation. Brain Res 374: 153–161
Arnold R, Lankisch PG (1980) Somatostatin and the gastrointestinal tract. Clin. Gastroenterol. 9: 733–753
Aronin N, Cooper PE, Lorenz LJ, Bird DE, Sagar SM, Leeman SE, Martin JB (1983) Somatostatin is increasd in the basal ganglia in Huntington’s disease. Ann. Neurol. 13: 519–526
Atack JR, Beal MF, May C, Kaye JA, Mazureck MF, Kay AD, Rapoport SI (1988) Cerebrospinal fluid somatostatin and neuropeptyde Y; concentrations in aging and in dementia of the Alzheimer type with and without extrapyramidal signs. Arch Neurol 45: 269–274
Bilezykjian LM, Vale W (1983) Stimulation of adenosine 3’5’-monophosphate production by growth hormone releasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro. Endocrinology 113: 1726–1731
Bakhit C, Benoit R, Bloom FE (1983) Effects of cysteamine on pro-somatostatin related peptides. Reg Peptides 6: 169–177
Beal MF, Domesick VB, and Martin JB (1983) Regional somatostatin distribution in the rat striatum. Brain Res 278: 103–108
Beal MF, and Martin JB (1984) Depletion of striatal somatostatin by local cysteamine injection. Brain Res 308: 319–324
Beal MF, Mazurek MF, Tran VT, Chattha G, Bird ED, Martin JB (1985) Reduced number of somatostatin receptors in the cerebral cortex in Alzheimer’s disease. Science 229: 289–291
Beal MF, Benoit R, Mazurek MF, Bird ED, Martin JB (1986) Somatostatin-28(1–12)-like immunoreactivity is reduced in Alzheimer’s disease cerebral cortex. Brain Res. 368: 380–383
Beal MF, Mazurek MF and JB Martin (1987) A comparison of somatostatin and neuropeptide Y distribution in monkey brain. Brain Res. 405: 213–219.
Bennet GW, Edwardson JA, Marcano de Cotte D, Berelowitz M, Pimstone B and Kronheim GH. (1979) Release of somatostatin from rat brain synaptosomes. J. Neurochem. 32: 1127–1130
Bolaffi JL, Reichlin S, Goodman DBP, Forrest JN Jr (1980) Somatostatin: occurrence in urinary bladder epithelium and renal tubules of the toad, Bufo marinus. Science 210: 644–646
Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic peptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179: 77–7
Chasselet MF, Reisine TD (1983) Somatostatin regulates dopamine release in rat striatal slices and rat caudate nuclei. J Neurosci. 3: 232–236
Chneiweiss H, Glowinski J, Premont J (1985) Modulation by monoamines of somatostatin-sensitive adenylate cyclase on neuronal and glial cells from the mouse brain in primary coltures. J. Neurochem 44: 1825–1831
Comb M, Birnberg NC, Seasholtz A, Herbert E, and HM Goodman (1986) A cyclic AMP and phorbol ester-inducible DNA element. Nature 323: 353–356
Cook LL, Faux GA, Knight DL, Bissette G, Nemeroff CB (1989) Assessment of somatostatin-acetylcholine interactions in the rat cerebral cortex. 19th Annual Meeting of the Society for Neuroscience abs 394. 16
Costantidinis J, Bouras C, and PG Vallet (1988) Neuropeptides in Alzheimer’s and Parkinson’s disease. Mount Sinai J Med 55: 102–115
Cronin MJ, Hewlett E, Evans W, Thorner M, Rogol A (1984) Human pancreatic tumor growth hormone (GH)-releasing factor and cAMP evoke GH release from anterior pituitary cells: the effect of pertussis toxin, cholera toxin, forskolin and cycloheximide. Endocrinology 114: 904–910
Cumin R, Bandle EF, Gazmu E, Haefely WE, (1982) Effects of a the novel compound aniracetam (Ro 13–5057) upon impaired learning and memory in rodents. Psychpharmacology 78: 104–108
Davies P, Katzman R, Terry RD (1980) Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer senile dementia. Nature 288: 279–280
Epelbaum J, Brazeau P, Tsang D, Brawer J and Martin JB (1977) Subcellular distribution of radioimmunoassayable somatostatin in rat brain. Brain Res. 126: 309–323
Epelbaum J, Enjalbert A, Krantic S, Musset F, Bertrand P, Rasolonjanahary R, Shu C, Kordon C (1987) Somatostatin receptors on pituitary somatotrophs, thyrotrophs and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase. Endocrinology 121: 2177–2185
Florio T, Magri G, Landolfi E, Meucci O, Grimaldi M, Schettini G, Marino A (1988) Depletion of brain somatostatin by cysteamine induces impairment of cognitive functions in rat: reversal by administration of exogenous somatostatin or its analogue SMS 201–995. Pharmacol. Res. Commun. 20: 241–242
Gerich JE. Somatostatin and diabetes (1981) Am. J. Med. 70: 619–626
Gomez S, Davous P, Rondot P, Faivre-Bauman A, Valade D, and Puymirat J (1986) Somatostatin-like immunoreactivity and acetylcholinesterase activities in cerebrospinal fluid of patients with Alzheimer disease and senile dementia of the Alzheimer type. Psychoneuroendocrinol. 11: 69–73
Krulich L, Dhariwal APS, McCann SM (1968) Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83: 783–790
Girod C, Dubois MP, Durand N (1980) Immunocytochemical evidence for the presence of somatostatin-like immunoreactivity in scattered cells of the duct system of the submandibular glands in the monkey Macaca irus. Histochemistry 69: 137–143
Goodman RH, Aron DC, Roos BA (1983) Rat pre-prosomatostatin. J. Biol. Chem. 258: 5570–5573
Haroutunian V, Mantin R, Campbell GA, Tsuboyama GK, and Davis KL (1987) Cysteamine-induced depletion of somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry. Brain Res 403: 234–242
He H-T and Reisine T (1989) Biochemical properties of the solubilized brain somatostatin receptor. 19th Ann. Meeting of Society for Neuroscience, abs 394. 17
Joynt RJ, and McNeill TH (1984) Neuropeptides in aging and dementia. Peptides 5 (suppl 1): 269–274
Lewis BM, Dieguez C, Lewis M, Hall R and MF Scanlon (1986) Hypothalamic D2 receptors mediate the preferential release of somatostatin-28 in response to dopaminergic stimulation. Endocrinology 119, 1712–1717
Luini A, Lewis D, Guild S, Schofield G, Weight F (1986) Somatostatin, an inhibitor of ACTH secretion, decreases cytosolic free calcium and voltage-dependent calcium current in a pituitary cell line. J. Neurosci. 6: 3128–3134
Mancillas JR, Siggins GR, and Bloom FE (1986) Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex. Proc Nat Acad Sci 83: 7518–7521
Mollard P, Vacher P, Dufy B, Barker JL (1988) Somatostatin blocks Ca++ action potential activity in prolactin-secreting pituitary tumor cells through coordinate actions on K+ and Ca+ conductances. Endocrinology 123: 721–732
Montminy MR, Goodman RH, Horovicth SJ, Habener JF (1984) Primary structure of the gene encoding rat preprosomatostatin. Proc. Natl. Acad. Sci. USA 81: 3337–3340
Montminy MR, Malcom JL, Tapia-Arancibia L, Reichlin S, Mandel G, RH Goodman (1986) Cyclic AMP regulates Somatostatin MRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. Journal of Neurosci. 6: 1171–1176
Montminy MR, and Bilezikjian (1987) Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328: 175–178
Morrison JH, Rogers J, Scherr S, Benoit R, Bloom FE (1985) Somatostatin immunoreactivity in neuritic plaques of Alzheimer’s patients. Nature 314: 90–92
Pares-Herbute N, Diaz J, Astier H, Tapia-Aranciba L (1989) Somatostatin inhibition ov VIP-induced somatostatin release, cyclic AMP accumulation and 45Ca+ uptake in diencephalic cells. Eur. J. Pharmacol. 161: 241–244
Quirion R, Martel JC, Robitaille Y, Etienne P, Wood P, Nair NPV, and Gauthier S (1986) Neurotransmitter and receptor deficits in senile dementia of the Alzheimer Type. J Can Sci Neurol 13: 503–506
Raynor K and Reisine T (1989) Cyclic analogs of somatostatin distinguish pharmacologically and functionally distinct subtypes of somatostatin receptors in brain and pituitary. 19th Ann. Meeting of Society for Neuroscience, abs 394. 17
Reichlin S. (1983a) Somatostatin (part I) N. Engl. J. Med. 309: 1495–1501
Reichlin S (1983b) Somatostatin. In: Krieger DT, Brownstein MJ, Martin JB (eds) Brain Peptides. Wiley Interscience Publication, New York, p 711
Reichlin S, and Bollinger-Gruber JA (1985) Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. Endocrinology 117: 492–495
Reisine T, Hung-Li W, Guild S Somatostatin inhibits cAMP-dependent and cAMP-independent calcium influx in the clonal pituitary tumor cell line AtT20 through the same receptor population. J. Pharmacol. Exp. Ther. 245: 225–231
Richardson SB, Hollander CS, D’Eletto R, Greenleaf PW and Thaw C (1980) Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro. Endocrinology 107: 122–129
Richardson SB, Twente S (1986) Inhibition of rat hypothalamic somatostatin release by somatostatin: evidence for somatostatin ultrashort loop feedback. Endocrinology 118: 2076–2082
Roberts GW, Crow TJ, Polak MJ (1985) Location of neuronal tangles in somatostatin neurons in Alzheimer’s disease. Nature 314: 92–94
Salomon Y, Londos C, Rodbel M (1974) A highly sensitive adenylate cyclase assay. Anal. Biochem. 58: 541–548
Schettini G, Florio T, Meucci O, Landolfi E, Lombardi G, Marino A (1988a) Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats. Brain Res. 439: 322–329
Schettini G, Florio T, Magri G, Grimaldi M, Meucci O, Landolfi E, Marino A (1988b) Somatostatin and SMS 201–995 reverse the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin. Eur. J. Pharmacol. 151: 399–407
Schettini G, Florio T, Meucci O, Landolfi E, Lombardi G, Marino A (1988c) Somatostatinergic and dopaminergic modulation of cognitive functions: behavioral and neurochemical studies. In: Current problems in senile dementias. A. Agnoli, J. Cahn, N. Lassen, R. Mayeux (eds) John Libbey Eurotext, London, pp 345
Schettini G, Florio T, Meucci O, Landolfi E, Grimaldi M, Ventra C, Marino A (1989) Somatostatin inhibition of adenylate cyclase activity in different brain areas. Brain Res. 492: 65–71
Schlegel W, Wuarin F, Wollheim CB, Zahnd GR (1984) Somatostatin lowers the cytosolic free Ca+ concentration in clonal rat pituitary cells (GH3 cells). Cell Calcium 5: 223–236
Seeman K, Daly JW (1981) Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J. Biol. Chem. 256: 9799–9801
Sessions GR, Demetriades E, Leber LL, Koob GF (1989) Cysteamine-induced somatostatin depletion and working memory deficits in rats. 19th Ann. Meeting of Society for Neuroscience abs. 288. 5
Shields D (1980) In vitro biosynthesis of fish islet preprosomatostatin: evidence of processing and segregation of a high molecular weight precursor. Proc. Natl. Acad. Sci. USA 77: 4074–4078
Sirvio J, Jolkkonen J, Pitkanen A, Riekkinen PJ (1987) Age dependence of somatostatin levels and somatostatin binding in the rat brain. Comp. Biochem. Physiol. 87: 355–357
Soininen H, Riekkinen PJ, Partanen J, Helkala EL, Laulumaa V, Jolkkonen J, and Reinikainen K (1988) Cerebrospinal fluid somatostatin correlates with spectral EEG variables and with parietotemporal cognitive disfunction in Alzheimer patients. Neurosci Lett 85: 131–136
Sorensen KV, Christensen SE, Hansen AP (1981) The origin of CSF somatostatin: hypothalamic or dispersed central nervous system secretion? Neuroendocrinology 32: 335–338
Srikant CB, and Patel YC (1981) Somatostatin analogs: dissociation of brain receptor binding affinities and pituitary actions in the rat. Endocrinology 108: 341–346
Srikant CB, and Patel YC (1984) Cysteamine induced depletion of brain somatostatin is associated with up-regulation of cerebrocortical somatostatin receptors. Endocrinology 115: 990–996
Steiner DF, Quinn PS, Chan SJ, Makh J, Tager HS (1980) Processing mechanism in the biosynthesis of proteins. Ann. N.Y. Acad. Sci. 343: 1–39
Stuble RG, Kitt CA, Walker LC, Cork LC, Price DL (1984) Somatostatinergic neurites in senile plaques of aged non-human primates. Brain Res. 324: 394–396
Sunderland T, Rubinow DR, Tariot PN, Cohen RM, Newhouse PA, Mellow AM, Mueller EA, Murphy DL (1987) CSF somatostatin in patients with Alzheimer’s disease, older depressed patients and age-matched control subjects. Am. J. Psychiatry 144: 1313–1316
Szabo S and Reichlin S (1981) Somatostatin in rat tissues is depleted by cysteamine administration. Endocrinology 109: 2255–2257
Tamminga TA, Foster NL, Fedio P, Bird ED, Chase TN (1987) Alzheimer’s disease: low cerebral somatostatin levels correlate with impaired cognitive functions and cortical metabolism. Neurology 37: 161–165
Tapia-Arancibia I, and S Reichlin (1984) Vasoactive intestinal polypeptide and PI-II stimulate somatostatin release from rat cerebral-cortical and diencephalic cells dispersed in cell culture. Brain Res. 336: 67–72
Thal LJ, Laing K, Horowitz SG and MH Makman (1986) Dopamine stimulates rat cortical somatostatin release. Brain Res 372: 205–209
Tran VT, Beal MF, Martin JB (1985) Two types of somatostatin receptors differentiated by cyclic somatostatin analogs. Science 228: 492–495
Tsujimoto A, and Tanaka S (1981) Stimulatory effect of somatostatin on norepinephrine release from rat brain cortex slices. Life Sci 28: 903–910
Van Noorden S, Polak JM, Pearse AGE (1977) Single cellular origin of somatostatin and calcitonin in the rat thyroid gland. Histochemistry 53: 243–247
Vecsei L, Kiraly C, Bollok I, Nagy A, Varga J, Penke B, Telegdy G (1984) Comparative studies into somatostatin and cysteamine in different behavioral tests on rats. Pharmacol. Biochem. Behay. 21: 833–890
Vecsei L, Balazs M, Bollok J, and Telegdy G (1985) Selective decrease of hypothalamic noradrenaline by cysteamine. Arch Int Pharmacodyn 274: 125–128
Vecsei L, Widerlov E (1988) Effects of intracerebroventricularly administered somatostatin on passive avoidance, shuttle box behaviour and open field activity. Neuropeptides 12: 237–242
Vecsei L (1989) Behavioral, pharmacological and neurochemical studies of somatostatin, cysteamine and panthetine. Studentliterature, Lund, p36
Vincent SR, Johanssen O, Hokfelt T, Skirboll A, Elde RP, Terenius L, Kimmel J, Goldstein M (1983) NADPH-diaphorase: a selective histo-chemical marker for striatal neurons containing both somatostatin and avian pancreatic polypeptide-like immunoreactivities. J. Comp. Neurol. 217: 252–263
Watson TWJ, Pittman QJ (1988) Somatostatin(14) and -(28) but not somatostatin(1–12) hyperpolarize CA1 pyramidal neurons in vitro. Brain Res. 448: 40–45
Widmann R, Mensdorff-Pouilly N, Pfaller K, and Sperk G (1987a) Evidence for somatostatin-containing fibers projecting from the pallidal complex to the striatum of the rat. J Neurochem 48: 1857–1861
Widmann R, and Sperk G (1987) Cysteamine-induced decrease of somatostatin in rat brain synaptosomes in vitro. Endocrinology 121: 1383–1389
Yamashita N, Shibuya N, Ogata E (1988) Requirement of GTP on somatostatin-induced K+ current in human pituitary tumor cells. Proc. Natl. Acad. Sci. USA 85: 4924–4928
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Schettini, G., Florio, T., Ventra, C., Postiglione, A. (1990). Somatostatin and Brain Aging. In: Beyreuther, K., Schettler, G. (eds) Molecular Mechanisms of Aging. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1990 / 1990/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84224-5_12
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