The Brain Disease of Ageing — Epidemiology and Risk Factors of Senile Dementia (Alzheimer)

  • H. Häfner
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1990 / 1990/2)


With his description of a case of severe senile dementia of early onset in 1907, Alois Alzheimer (1907a,b) gave an account of the disease which is still valid today: the clinical aspects of a progressive loss of cognitive, mnestic and language functions and the neuropathological aspect of a degeneration of ganglia and an agglomeration of neurofibrillary tangles and plaques in the cerebral cortex and in the hippocampus. The establishment of an exact diagnosis of dementia of Alzheimer’s type still requires positive findings in both clinical and neuropathological fields. The latter can hardly be obtained from population studies. Peripheral markers which would allow to make a correct diagnosis are not yet at our disposal.


Vascular Dementia Senile Dementia Severe Dementia Social Risk Factor Male Female Male Female 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Häfner
    • 1
  1. 1.Central Institute of Mental HealthMannheim 1Germany

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