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Concomitant Continuous Infusion Chemotherapy and Radiation pp 77–84Cite as

Hypoxic Cell Sensitizers

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The hypoxic cell radiosensitizers are included in the broad field of chemical modifiers of cancer treatment. The chemical modifiers of radiation include the radiation sensitizers and protectors, which are theoretically of no therapeutic value by themselves but are clinically active only when used in conjunction with irradiation. Combined modality therapy using radiation therapy with the standard cytotoxic chemotherapeutic agents is the major focus of this symposium. Such treatment may be designed to maximize the interaction between the radiation and chemotherapy rather than emphasizing one of the individual modalities. The radiation modifiers have also been developed as chemomodifiers, both chemosensitizers and normal tissue protectors. The overall field of chemical modifiers has been recently reviewed in detail (Coleman 1988, 1989; Coleman et al. 1988a, 1989a, b). This article will highlight some of the rationale for the clinical use of radiation and chemotherapy modifiers, with particular emphasis on the use of the hypoxic cell sensitizers as a continuous infusion.

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Author information

Authors and Affiliations

  1. Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney Street, Boston, MA, 02115, USA

    C. Norman Coleman MD (Professor and Chairman)

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  1. C. Norman Coleman MD
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Editors and Affiliations

  1. SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Ave., Box 1211, Brooklyn, 11203-2098, USA

    Marvin Rotman MD (Professor and Chairman, Dept. of Radiation Oncology) & C. Julian Rosenthal MD (Professor of Medicine and Oncology) (Professor and Chairman, Dept. of Radiation Oncology) &  (Professor of Medicine and Oncology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Coleman, C.N. (1991). Hypoxic Cell Sensitizers. In: Rotman, M., Rosenthal, C.J. (eds) Concomitant Continuous Infusion Chemotherapy and Radiation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84186-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-84186-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84188-0

  • Online ISBN: 978-3-642-84186-6

  • eBook Packages: Springer Book Archive

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