Infusion Adriamycin and Radiation in Hepatomas
Hepatocellular carcinoma is a highly malignant tumor with a median survival time of only 4 months from the onset of symptoms and 2 months from the diagnosis (Nagasue et al. 1984; Falkson and Coetzer 1986). While radiation has some activity, its effectiveness is limited by the liver tolerance (zum Winkel et al. 1986). Cytotoxic chemotherapy has usually produced disappointing results (Falkson and Coetzer 1986). New approaches are needed for the treatment of this disease. One such new approach is the concomitant use of hepatic radiation and chemotherapy. The optimal chemotherapy would be drugs which are both individually active in the treatment of hepatocellular carcinoma as well as having a potential for radiation sensitization.
KeywordsResponse Duration Intrahepatic Cholestasis Hepatocellular Cancer Metastatic Liver Cancer Radiation Therapy Oncology Group Study
Unable to display preview. Download preview PDF.
- Falkson G, Coetzer BJ (1986) Application and results of different chemotherapy regimens in primary liver malignancies. In: Herfarth C, Schlag P, Hohenberger P (eds) Therapeutic strategies in primary and metastatic liver cancer. Springer, Berlin Heidelberg New York (Recent Results in Cancer Research, vol 100, pp 103–111)CrossRefGoogle Scholar
- Rosenthal CJ, Rotman M, Bhutiani I (1986) Concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies - a phase I-II study - evidence of synergistic effect in soft tissue sarcomas and hepatomas. In: Rosenthal CJ, Rotman M (eds) Clinical applications of continuous infusion chemotherapy and concomitant radiation therapy. Plenum, New York, pp 159–175CrossRefGoogle Scholar
- Zum Winkel K, Wieland C, Weischedel N (1986) Therapeutic strategies in primary and metastatic liver cancer: indication and results of external radiation therapy. In: Herfarth C, Schlag P, Hohenberger P (eds) Therapeutic strategies in primary and metastatic liver cancer. Springer, Berlin Heidelberg New York (Recent Results in Cancer Research, vol 100, pp 289–297)CrossRefGoogle Scholar