Soft Tissue Sarcomas of the Extremities
The procurement of high local control rates using a combined modality approach and preservation of functional extremities represent two challenges in the treatment of soft tissue sarcomas located in the extremities (Eilber et al. 1980). Systemic therapy is an important component of the treatment of high grade sarcomas and/or large primary tumors, in which the development of distant metastases still makes it difficult to achieve definitive cure of the disease. Randomized trials have established that survival is not compromised by extremity preservation treatment, and adequate combination of surgery and radiotherapy yields survival data as good as those achieved by amputation (Rosenberg et al. 1982). Local recurrences occur in 20% – 25% of cases treated by conventional surgical resection and external beam radiotherapy (Suit et al. 1985). IORT is an alternative boosting technique that has rarely been explored in a systematic fashion in soft tissue sarcomas of the extremities (Dobelbower and ABE 1989).
KeywordsSoft Tissue Sarcoma External Beam Radiotherapy Synovial Sarcoma Malignant Fibrous Histiocytoma High Grade Sarcoma
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- Campbell W, Beloqui O, Herranz P et al. (1988) Ifosfamide (IFX), doxorubicin (ADM), dacarbazine (DTIC), and amphotericin B ( AMB) in metastatic soft tissue sarcoma. Proc Am Assoc Cancer Res 29: 222Google Scholar
- Dobelbower RR, Abe M (1989) Intraoperative radiation therapy. CRC, Boca Raton, FlGoogle Scholar
- Gillette EL, Powers BE, McChesney SL et al. (1988) Response of aorta and branch arteries to experimental intraoperative irradiation. Int J Radiat Oncol Biol Phys 15 [Suppl 1]: 202Google Scholar
- Kinsella TJ, Sindelar WF (1985) Intraoperative radiotherapy. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology. JB Lippincott, Philadelphia, pp 2293–2304Google Scholar
- Kinsella TJ, Sindelar WF, De Luca AM (1988) Threshold dose for peripheral nerve injury following intraoperative radiotherapy (IORT) in a large animal model. Int J Radiat Oncol Biol Phys 15 [Suppl 1]: 205Google Scholar
- Powers BE, Gillette EL, McChesney SL et al. (1989a) Muscle injury following experimental intraoperative irradiation. Int J Radiat Oncol Biol Phys 17 [Suppl 1]: 246Google Scholar
- Rosenberg SA, Tepper JE, Glatstein E et al. (1982) The treatment of soft tissue sarcomas of the extremities. Prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196: 305–314PubMedCrossRefGoogle Scholar
- Suit HD (1983) Patterns of failure after treatment of sarcoma of soft tissue by radical surgery or by conservative surgery and radiation. Cancer Treat Symp 2: 241–246Google Scholar
- Tepper JE, Wood WC, Suit HD (1989) Intraoperative radiation therapy of soft tissue sarcomas. In: Dobelbower RR, Abe M (eds) Intraoperative radiation therapy. CRC, Boca Raton, Fl, pp 275–278Google Scholar