Application of NIR Spectroscopy to Problems of Tissue Oxygenation

  • C. A. Piantadosi
  • W. J. Parsons
  • J. A. Griebel
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 12)


Over the past few years, several new technologies have emerged with the potential to evaluate regional oxygenation and oxidative metabolism. Among these technologies are complex optical methods that have been developed primarily for the research laboratory. Optical measurements of the oxygenation of hemoglobin and myoglobin in tissue [1] reduced pyridine nucleotides [2] and the oxidation-reduction status of cytochrome c oxidase and other cytochromes [3] have been used for many years as intracellular indicators to study oxidative metabolism noninvasively. One of the newer optical techniques, Near Infrared Spectroscopy (NIRS), has shown promise as a continuous, noninvasive indicator of regional oxidative metabolism in intact tissue. We will briefly review the principles of NIR spectroscopy and indicate how we are using NIRS to investigate some of the pertinent questions about tissue oxygenation in disease states.


Cerebral Oxygenation Intact Brain Hemoglobin Saturation Hypoxic Hypoxia Optical Pathlength 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • C. A. Piantadosi
  • W. J. Parsons
  • J. A. Griebel

There are no affiliations available

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