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Multiple Organ Failure: Is It Only Hypoxia?

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 12))

Abstract

Multiple organ failure persists as a major cause of morbidity and mortality in surgical patients with a mortality rate in the 50–60% range and intensive care unit stays of three to four weeks or longer [1]. With the advent of modern Intensive Care Unit (ICU) care, the outcome improved. For the last several years, however, there has been no improvement in spite of better modes of ventilation, antibiotics, nutrition and metabolic support, gut decontamination, and better technology for the care of the critically ill and injured [2].

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References

  1. Madoff RD, Sharpe SM, Fath JJ, et al (1986) Prolonged surgical intensive care. Arch Surg 120: 698

    Google Scholar 

  2. Cerra FB, Abrams J, Negro F, et al (1990) Multiple organ failure syndrome: Patterns and effect of current therapy. Update in intensive care and emergency medicine, vol 10: Update 1990. Springer, Berlin Heidelberg New York Tokyo, pp 22–31

    Google Scholar 

  3. Cerra FB (1989) Multiple organ failure syndrome. In: Bihari DJ, Cerra FB (eds) New horizons: Multiple organ failure syndrome. Society of Critical Care Medicine, California, pp 1–25

    Google Scholar 

  4. Bihari DJ, Cerra FB (1989) Overview of multiple organ failure syndrome. In: Bihari DJ, Cerra FB (eds) New horizons: Multiple organ failure syndrome. Society of Critical Care Medicine, California, pp 391–397

    Google Scholar 

  5. Bihari D (1988) Oxygen delivery and consumption in the critically ill: their relation to the development of multiple organ failure. In: Kox W, Bihari D (eds) Shock and the adult respiratory distress syndrome. Springer, Berlin Heidelberg New York Tokyo, pp 95–124

    Chapter  Google Scholar 

  6. Shoemaker WC (1985) Hemodynamic and oxygen transport patterns in septic shock: Physiologic mechanisms and therapeutic implications. In: Sibbald W, Sprung C (eds) New horizons: Perspectives in sepsis and septic shock. Society of Critical Care Medicine, California, pp 203–234

    Google Scholar 

  7. Shoemaker W, Appel PL, Kram HB (1989) Tissue oxygen debt as a determinant of lethal and nonlethal postoperative organ failure. Crit Care Med 16: 1117–1121

    Article  Google Scholar 

  8. Cerra FB (1987) Hypermetabolism, organ failure, and metabolic support. Surgery 191: 1–9

    Google Scholar 

  9. Chaudry IH, Herkema JM, Dean RE (1989) Alterations in energy production: A manifestation of cell injury. In: Bihari DJ, Cerra FB (eds) New horizons: Multiple organ failure syndrome. Society of Critical Care Medicine, California, pp 277–297

    Google Scholar 

  10. Keller GA, West MA, Cerra FB, Simmon RL (1985) Multiple system organ failure: Modulation of hepatocyte protein synthesis by endotoxin activated Kuppfer cells. Ann Surg 201: 87–95

    Google Scholar 

  11. Keller GA, West MA, Cerra FB, Simmon RL (1985) Multiple system organ failure: Modulation of hepatocyte protein synthesis by endotoxin activated Kuppfer cells. Ann Surg 201: 87–95

    Google Scholar 

  12. Keller GA, West MA, Cerra FB, Simmon RL (1985) Multiple system organ failure: Modulation of hepatocyte protein synthesis by endotoxin activated Kuppfer cells. Ann Surg 201: 87–95

    Google Scholar 

  13. Keller GA, West MA, Cerra FB, Simmon RL (1985) Multiple system organ failure: Modulation of hepatocyte protein synthesis by endotoxin activated Kuppfer cells. Ann Surg 201: 87–95

    Google Scholar 

  14. Siegel JH, Cerra FB, Coleman B (1976) Physiologic and metabolic correlations in human sepsis. Arch Surg 86: 163–193

    Google Scholar 

  15. Bihari D, Smithies M, Gimson A, et al (1987) The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 317: 397–402

    Article  PubMed  CAS  Google Scholar 

  16. Gutierrez G, Pohil R (1986) Oxygen consumption is linearly related to the oxygen supply in critically ill patients. J Crit Care 1: 45–51

    Article  Google Scholar 

  17. Danek S, Lynch J, Weg J, et al (1980) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122: 387–391

    PubMed  CAS  Google Scholar 

  18. Danek S, Lynch J, Weg J, et al (1980) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122: 387–391

    PubMed  CAS  Google Scholar 

  19. Cerra FB, Siegel J, Border J (1979) Proline metabolism in sepsis, cirrhosis and general surgery. Ann Surg 190: 577–585

    Article  PubMed  CAS  Google Scholar 

  20. Long CL, Jeevanaudan M, Kinney JM (1977) Whole body protein synthesis and catabolism in septic man 30: 1340

    CAS  Google Scholar 

  21. Cerra FB, Coleman JH, Coleman B, Border JR (1980) Septic autocanabolism: A failure of exogenous nutrition support. Ann Surg 192: 570–574

    Google Scholar 

  22. Cloves GHA, Georg BC, Villu CA (1983) Muscle proteolysis induced by a circulating peptide in patients with trauma and sepsis. N Engl J Med 303: 545–549

    Google Scholar 

  23. Shau JHF, Wolf RN (1987) Glucose and urea kinetics in patients with GI cancer. Surgery 101: 181–189

    Google Scholar 

  24. Wolf R, Allsap J, Burke J (1970) Glucose metabolism in man: Response to intravenous glucose infusion. Metabolism 28: 210–216

    Google Scholar 

  25. Powell-Tuck J, Fern E, Garlich P (1984) Effect of surgical trauma and insulin on whole body protein turnover in parenterally fed, undernourished patients. Hum Nut Clin Nut 38: 11–19

    CAS  Google Scholar 

  26. Ramsey G, Ledingham I (1989) Management of multiple organ failure: Control of the microbial environment. In: Bihari DJ, Cerra FB (eds) New horizons: Multiple organ failure syndrome. Society of Critical Care Medicine, California, pp 327–337

    Google Scholar 

  27. Vilcek LEJ (1987) Biology of disease TNF and IL-1: Cytokines with multiple overlapping biological activities. Lab Invest 56: 234–248

    PubMed  Google Scholar 

  28. Watters JM, Bessey P, Dinarello CA (1986) Both inflammatory and endocrine mediators stimulate host response to sepsis. Arch Surg 121: 179–183

    Article  PubMed  CAS  Google Scholar 

  29. Remich DG, Punkel RG, Larich JW (1987) Acute in vivo effects of human rTNF. Lab Invest 56: 583–589

    Google Scholar 

  30. Danner RL, Natanson C, Suffredini AE, Parrillo (1989) Microbial toxins: Role in pathogenesis of septic shock and MOF. In: Bihari DJ, Cerra FB (eds) New horizons: Multiple organ failure syndrome. Society of Critical Care Medicine, California, pp 151–193

    Google Scholar 

  31. Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Macvittie TJ, Parrillo JE (1989) Endotoxin and TNF challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 169: 823–832

    Article  PubMed  CAS  Google Scholar 

  32. Glauser FL, Bechare DE, Deblois GG, Fowler AA, Fairman RP (1989) Cardiorespiratory and cellular changes with IL-2 infusion in sheep. J Appl Physiol 66: 128–134

    PubMed  CAS  Google Scholar 

  33. Walvatne C, Johnson A, Ashlin D, Cerra FB. Effect of LPS and IL-2 infusion on myocardial performance and plasma cytokine levels. Circ Shock (submitted)

    Google Scholar 

  34. Bankey PE, Wang WY, Carlson AM, Singh RK, Holman RT, Cerra FB (1989) Nutritional pharmacology alters the inflammatory response to endotoxin in vivo. Crit Care Med 17 (4): S64

    Google Scholar 

  35. Bankey P, Fiegel B, Singh R, Knighton D, Cerra FB (1989) Hypoxia and endotoxin induce macrophage-mediated suppression of fibroblast proliferation. J Trauma 29 (7): 972–980

    Article  PubMed  CAS  Google Scholar 

  36. Mazuski JE, Bankey PE, Carlson A, Cerra FB (1988) Hepatocytes release factors that can modulate macrophage IL-1 secretion and proliferation. Surgical Forum October, 1988

    Google Scholar 

  37. Morris A, Henry W, Shearer J, et al (1985) Macrophage interaction with skeletal muscle: A potential role of macrophages in determining the energy state of healing wounds. J Trauma 25: 751–755

    Google Scholar 

  38. Cerra FB et al (1979) Hepatic failure of sepsis. Surgery 86: 489–492

    Google Scholar 

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© 1991 Springer-Verlag Berlin Heidelberg

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Cerra, F.B. (1991). Multiple Organ Failure: Is It Only Hypoxia?. In: Gutierrez, G., Vincent, J.L. (eds) Tissue Oxygen Utilization. Update in Intensive Care and Emergency Medicine, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84169-9_19

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  • DOI: https://doi.org/10.1007/978-3-642-84169-9_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52472-4

  • Online ISBN: 978-3-642-84169-9

  • eBook Packages: Springer Book Archive

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